Human C-X-C motif chemokine 3(CXCL3) ELISA kit
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中文名稱：人C-X-C趨化因子3(CXCL3)酶聯(lián)免疫試劑盒
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貨號：CSB-EL006249HU
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規(guī)格：96T/48T
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價格：￥3600/￥2500
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：人C-X-C趨化因子3(CXCL3)酶聯(lián)免疫試劑盒（CSB-EL006249HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CXCL3含量。CXCL3 作為一個靶點，在生物學(xué)領(lǐng)域有重要意義。它參與多種生理和病理過程。研究發(fā)現(xiàn)，CXCL3 可能與炎癥反應(yīng)、腫瘤發(fā)展等機(jī)制相關(guān)。針對它的研究主要聚焦于其信號傳導(dǎo)通路，以探尋調(diào)控其活性的方法，從而為相關(guān)疾病治療提供新思路。試劑盒檢測范圍為9.37 pg/mL-600 pg/mL，該產(chǎn)品適用于體外檢測人或相關(guān)模式生物（經(jīng)交叉反應(yīng)驗證）來源樣本中CXCL3的表達(dá)動態(tài)，可為炎癥性疾病機(jī)制研究、免疫調(diào)控通路探索或藥物開發(fā)中的生物標(biāo)志物分析提供靈敏、穩(wěn)定的檢測工具，尤其適合基礎(chǔ)科研中涉及趨化因子網(wǎng)絡(luò)調(diào)控、免疫微環(huán)境分析或病理模型驗證等研究方向。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
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別名：C-X-C motif chemokine 3 ELISA Kit; C-X-C motif chemokine ligand 3 ELISA Kit; Chemokine (C X C motif) ligand 3 ELISA Kit; Chemokine (CXC motif) ligand 3 ELISA Kit; Cinc 2 ELISA Kit; CINC 2b ELISA Kit; Cinc2 ELISA Kit; CINC2b ELISA Kit; CXCL 3 ELISA Kit; Cxcl3 ELISA Kit; CXCL3_HUMAN ELISA Kit; Cytokine induced neutrophil chemoattractant 2 ELISA Kit; Dcip1 ELISA Kit; Dendritic cell inflammatory protein 1 ELISA Kit; Gm1960 ELISA Kit; GRO protein gamma ELISA Kit; GRO-gamma ELISA Kit; GRO-gamma(1-73) ELISA Kit; GRO-gamma(5-73) ELISA Kit; GRO3 ELISA Kit; GRO3 oncogene ELISA Kit; GROG ELISA Kit; Growth regulated protein gamma ELISA Kit; Growth-regulated protein gamma ELISA Kit; Macrophage inflammatory protein 2 beta precursor ELISA Kit; Macrophage inflammatory protein 2-beta ELISA Kit; Melanoma growth stimulatory activity gamma ELISA Kit; Member 3 ELISA Kit; MGSA gamma ELISA Kit; MIP 2b ELISA Kit; MIP2-beta ELISA Kit; MIP2B ELISA Kit; SCYB3 ELISA Kit; Small inducible cytokine subfamily B ELISA Kit
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縮寫：
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Uniprot No.：
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種屬：Homo sapiens (Human)
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樣本類型：serum, plasma, tissue homogenates
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檢測范圍：9.37 pg/mL-600 pg/mL
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靈敏度：2.34 pg/mL
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反應(yīng)時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領(lǐng)域：Immunology
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測定原理：quantitative
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測定方法：Sandwich
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精密度：
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度：
To assess the linearity of the assay, samples were spiked with high concentrations of human CXCL3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 90 Range % 87-93 1:2 Average % 100 Range % 97-103 1:4 Average % 95 Range % 92-97 1:8 Average % 99 Range % 95-102 -
回收率：
The recovery of human CXCL3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 94 91-97 EDTA plasma (n=4) 97 93-99 -
標(biāo)準(zhǔn)曲線：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
pg/ml OD1 OD2 Average Corrected 600 2.943 2.888 2.916 2.764 300 2.188 2.299 2.244 2.092 150 1.458 1.392 1.425 1.273 75 0.778 0.790 0.784 0.632 37.5 0.392 0.382 0.387 0.235 18.75 0.288 0.269 0.279 0.127 9.37 0.240 0.234 0.237 0.085 0 0.153 0.151 0.152 -
數(shù)據(jù)處理：
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貨期：3-5 working days
引用文獻(xiàn)
- High and selective cytotoxicity of ex vivo expanded allogeneic human natural killer cells from peripheral blood against bladder cancer: implications for natural killer cell instillation after transurethral resection of bladder tumor CL Yeh,Journal of experimental & clinical cancer research,2024
產(chǎn)品評價
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靶點詳情
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功能：Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.
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基因功能參考文獻(xiàn)：
- CXCL3 exerts its carcinogenic potential by directly and/or indirectly regulating the downstream signaling pathways and the expression of transcription factors in PCa. PMID: 29524043
- Exogenous CXCL3 induced Erk1/2 and ETS1 phosphorylation and promoted CD133 expression. PMID: 27255419
- Our findings suggest that CXCL3 and its receptor CXCR2 are overexpressed in prostate cancer cells, prostate epithelial cells and prostate cancer tissues, which may play multiple roles in prostate cancer progression and metastasis. PMID: 26837773
- results support a functional role of CXCL3 in breast cancer metastasis and as a viable target for cancer therapy PMID: 24605943
- CXCL3 displays antimicrobial activity against E. coli and S. aureus. PMID: 12949249
- secreted growth-regulated oncogene chemokines, specifically GRO-gamma, in human Mesenchymal stromal cell-conditioned media have an effect on the differentiation and the function of human monocyte-derived dendritic cells. PMID: 23589610
- Data show that mesenchymal stem cells (MSCs) directly regulate T cell proliferation by induction of CXCL3 chemokine and its receptor, CXCR2 on the surface in T cells. PMID: 23023221
- demonstrates, for the first time, that BIRC3 (anti-apoptotic protein), COL3A1 (matrix protein synthesis), and CXCL3 (chemokine) were up-regulated in the thrombin-stimulated human umbilical vein endothelial cells PMID: 16356540
- GRO-gamma is a promising candidate for Th2-associated glomerular permeability factor in minimal change disease. PMID: 17389786
- Inhibition of ERK phosphorylation decreased expression of GRO3. PMID: 17466952
- Report gonadotropin-releasing hormone-regulated CXCL3 expression in human placentation. PMID: 19369450
- propose that chemokines belonging to the CXC family could play an important role in the etiology of tendon xanthoma (TX), with CXCL3 being a possible biological marker of onset and development of TX PMID: 19448742
- overexpression of CXCL13 in the intestine during inflammatory conditions favors mobilization of B cells and of LTi and NK cells with immunomodulatory and reparative functions. PMID: 19741597
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亞細(xì)胞定位：Secreted.
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蛋白家族：Intercrine alpha (chemokine CxC) family
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數(shù)據(jù)庫鏈接：
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