DLL3

DLL3，即Delta樣配體3，別名Delta3、delta-like3(Drosophila)、delta-likeprotein3、Pudgy、SCDO1、SCDO1delta3。它是一種屬于Delta/Serrate/Lag-2(DSL)家族的Notch配體，主要在神經(jīng)內(nèi)分泌腫瘤細胞表面表達，而在正常成人組織中幾乎不表達。DLL3的作用機制涉及與Notch受體相互作用，通常作為抑制性配體，通過與Notch受體結(jié)合抑制Notch信號通路的激活，影響腫瘤細胞的增殖、分化和凋亡。DLL3在小細胞肺癌（SCLC）中的表達尤為重要，其高表達與腫瘤的發(fā)生發(fā)展密切相關(guān)，是治療SCLC的潛在藥物作用靶點。DLL3的異常表達與多種神經(jīng)內(nèi)分泌腫瘤的發(fā)生有關(guān)，使其成為小細胞肺癌治療的重要生物標志物和治療靶點。

熱銷產(chǎn)品

Recombinant Human Delta-like protein 3 (DLL3), partial (CSB-EP882142HU1)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

DLL3 Recombinant Monoclonal Antibody (CSB-RA882142A1HU)

驗證數(shù)據(jù)

Untransfected HEK293 cells surface (green line) and transfected Human DLL3 HEK293 stable cells surface (red line) were stained with anti-DLL3 antibody (rovalpituzumab-like) (2μl/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG1 Fc antibody and analyzed with flow cytometry.

The Binding Activity of DLL3 with Anti-DLL3 Recombinant Antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized DLL3 (CSB-MP3536MOV) at 2 μg/mL can bind Anti-DLL3 Recombinant Antibody(CSB-RA882142A1HU), the EC₅₀ is 1.625-2.702 ng/mL.

The Binding Activity of DLL3 with Anti-DLL3 Recombinant Antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized DLL3 (CSB-MP882142HU) at 2 μg/mL can bind Anti-DLL3 Recombinant Antibody(CSB-RA882142A1HU), the EC₅₀ is 1.102-1.707 ng/mL.

The purity of DLL3 was greater than 95% as determined by SEC-HPLC

Human Delta-like protein 3(DLL3) ELISA kit (CSB-EL006948HU)

驗證數(shù)據(jù)

貨號：CSB-EL006948HU

規(guī)格：96T/48T

靈敏度：4.68 pg/mL

檢測范圍：18.75 pg/mL-1200 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

DLL3 Antibody

DLL3 Protein

DLL3 ELISA Kit

DLL3 Antibodies

DLL3 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應性	應用類型
CSB-PA882142LA01HU	DLL3 Antibody	Human	ELISA, IHC
CSB-PA882142LB01HU	DLL3 Antibody, HRP conjugated	Human	ELISA
CSB-PA882142LC01HU	DLL3 Antibody, FITC conjugated	Human
CSB-PA882142LD01HU	DLL3 Antibody, Biotin conjugated	Human	ELISA
CSB-RA882142A1HU	DLL3 Recombinant Monoclonal Antibody	Human	ELISA, FC
CSB-RA882142MA2HU	DLL3 Recombinant Monoclonal Antibody	Human	ELISA, FC

DLL3 Proteins

DLL3 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP006948MO1 CSB-EP006948MO1 CSB-BP006948MO1 CSB-MP006948MO1 CSB-EP006948MO1-B	Recombinant Mouse Delta-like protein 3 (Dll3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF006948MO	Recombinant Mouse Delta-like protein 3 (Dll3)	in vitro E.coli expression system

DLL3 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP006948RA1 CSB-EP006948RA1 CSB-BP006948RA1 CSB-MP006948RA1 CSB-EP006948RA1-B	Recombinant Rat Delta-like protein 3 (Dll3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF006948RA	Recombinant Rat Delta-like protein 3 (Dll3)	in vitro E.coli expression system

DLL3 Proteins for Xenopus laevis (African clawed frog)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP346574XBE CSB-EP346574XBE CSB-BP346574XBE CSB-MP346574XBE CSB-EP346574XBE-B	Recombinant Xenopus laevis Homeobox protein DLL-3 (dll3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

DLL3 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP882142HU	Recombinant Human Delta-like protein 3 (DLL3), partial	Yeast
CSB-EP882142HU	Recombinant Human Delta-like protein 3 (DLL3), partial	E.coli
CSB-EP882142HU1	Recombinant Human Delta-like protein 3 (DLL3), partial	E.coli
CSB-MP882142HU	Recombinant Human Delta-like protein 3 (DLL3), partial (Active)	Mammalian cell
CSB-EP882142HU2-B	Recombinant Human Delta-like protein 3 (DLL3), partial,Biotinylated	E.coli
CSB-MP882142HU2	Recombinant Human Delta-like protein 3 (DLL3), partial (Active)	Mammalian cell
CSB-MP882142HU2d7	Recombinant Human Delta-like protein 3 (DLL3), partial (Active)	Mammalian cell
CSB-MP882142HU3	Recombinant Human Delta-like protein 3 (DLL3), partial (Active)	Mammalian cell
CSB-MP882142HU3d7	Recombinant Human Delta-like protein 3 (DLL3), partial (Active)	Mammalian cell