Human Interleukin-27 receptor subunit alpha(IL27RA) ELISA kit
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中文名稱：人白介素-27受體α亞基(IL27RA)酶聯(lián)免疫試劑盒
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貨號：CSB-EL011644HU
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規(guī)格：96T/48T
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價格：￥3600/￥2500
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其他：
產品詳情
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產品描述：人白介素-27受體α亞基(IL27RA)酶聯(lián)免疫試劑盒（CSB-EL011644HU）檢測樣本中的IL27RA含量。IL27RA是一個重要靶點。它是IL - 27的受體，在免疫調節(jié)中發(fā)揮關鍵作用。相關研究聚焦其信號傳導機制，旨在了解它如何調控免疫細胞的功能、增殖與分化，以及在炎癥性疾病和腫瘤免疫中所起的作用，為開發(fā)針對性治療策略提供依據。本試劑盒可滿足免疫學機制研究、藥物靶點篩選或疾病模型構建等場景需求，助力研究者高效開展IL27RA相關信號通路與免疫調節(jié)功能的探索。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
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別名：Class I cytokine receptor ELISA Kit; CRL1 ELISA Kit; Cytokine receptor-like 1 ELISA Kit; I27RA_HUMAN ELISA Kit; IL-27 receptor subunit alpha ELISA Kit; IL-27R subunit alpha ELISA Kit; IL-27R-alpha ELISA Kit; IL-27RA ELISA Kit; IL27R alpha ELISA Kit; IL27R ELISA Kit; Il27ra ELISA Kit; Interleukin 27 receptor alpha chain precursor ELISA Kit; Interleukin 27 receptor ELISA Kit; Interleukin-27 receptor subunit alpha ELISA Kit; Protein CRL1 ELISA Kit; T cell cytokine receptor type 1 ELISA Kit; TCCR ELISA Kit; Type 1 T cell cytokine receptor ELISA Kit; Type I T-cell cytokine receptor ELISA Kit; WSX-1 ELISA Kit; WSX1 ELISA Kit; ZcytoR1 ELISA Kit
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縮寫：
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Uniprot No.：
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種屬：Homo sapiens (Human)
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檢測范圍：Request Information
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靈敏度：Request Information
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反應時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領域：Others
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貨期：3-5 working days
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相關問答
■ 常見問題解答
Q:
I would like to know the type of capture and secondary antibody included in the CSB-EL011644HU kit.
A:
Thanks for your inquiry!The capture is mouse monoclonal antibody and the detection antibody is goat polyclonal antibody
Q:
I want to know the antigen that each antibody catches.
A:
This kit is directed to extracellular domain（33-516）.The standard is 293 cell-derived recombinant protein and immunogen is 293 cell-derived recombinant protein
Q:
I would like to inquire about the sample type of ELISA Kit.
The product number is #CSB-EL011644H.
Can analyze cell supernants using this ELISA Kit?
Also, which media should I use to melt the standard?
A:
Thanks for your inquiry!We usually use this kit to detect serum, plasma, tissuehomogenates, cell lysates samples.The datasheet is attached for your information.We suggest the customer detect cell lysates samples.And he/she had better to do pre-testing first.
The standard in this kit is Frozen powder and it needs to be centrifuged.The customer can use Sample Diluent to melt the standard.He/She can refer to the "Standard" part on page 8.
The standard in this kit is Frozen powder and it needs to be centrifuged.The customer can use Sample Diluent to melt the standard.He/She can refer to the "Standard" part on page 8.
靶點詳情
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功能：Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and CNTFR. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.
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基因功能參考文獻：
- this study found elevated expression of IL-27 in human peripheral serum and elevated expression of its specific receptor (wsx-1) on fetal membranes in cases of preterm birth PMID: 28756371
- These results identify IL-27 and its specific receptor IL27RA as a critical immune axis for the antiviral immune response and as robust correlates of viral load and proviral reservoir size in mononuclear leukocytes in HIV infection. PMID: 28592538
- Findings demonstrated that IL-27 and IL-27R were elevated in multiple sclerosis lesions and that local IL-27 can modulate immune properties of astrocytes and infiltrating immune cells PMID: 26649511
- The significant expression of IL-27 in TB and the negative influence of IL-27R on T cell function demonstrate the pathway by which this cytokine/receptor pair is detrimental in TB. PMID: 26282876
- natural sIL-27Ralpha binds rIL-27, inhibits IL-27 binding to its cell surface receptor, and is a potent inhibitor of IL-27 signaling, as shown by its ability to specifically block IL-27-mediated STAT activation, at low molar excess over IL-27. PMID: 24771852
- Aberrant hypermethylation and reduced expression of IL27RA is associated with myelodysplastic syndromes. PMID: 22936014
- TCCR/WSX-1 is closely associated with angiogenesis and could serve as a novel therapeutic target in patients with age-related macular degeneration. PMID: 22312192
- Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity. PMID: 21631431
- WSX-1 is essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of Th1 cell differentiation. PMID: 12734330
- WSX-1 together with the cytokine receptor gp130 constitutes a functional signal-transducing receptor for IL-27. PMID: 14764690
- IL-27R possesses hematopoietic cell-transforming properties PMID: 18003935
- These results indicate that humanin protects neurons by binding to a complex or complexes involving CNTFR/WSX-1/gp130. PMID: 19386761
- Results reveal an interleukin 27-independent function of WSX1 sensitizing natural killer cell-mediated antitumor surveillance. PMID: 19549909
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亞細胞定位：Membrane; Single-pass type I membrane protein.
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蛋白家族：Type I cytokine receptor family, Type 2 subfamily
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組織特異性：Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, s
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