Human Platelet factor 4 variant(PF4V1) ELISA kit
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中文名稱：人血小板因子4變體(PF4V1)酶聯(lián)免疫試劑盒
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貨號(hào)：CSB-EL017810HU
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規(guī)格：96T/48T
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價(jià)格：￥3600/￥2500
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：人血小板因子4變體(PF4V1)酶聯(lián)免疫試劑盒（CSB-EL017810HU）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織培養(yǎng)上清液、組織勻漿樣本中的PF4V1含量。PF4V1，也稱為CXCL4L1，是一種血小板相關(guān)趨化因子，具有抗血管生成功能，與炎癥、血管生成和癌癥有關(guān)。其研究機(jī)制涉及結(jié)構(gòu)差異和功能特性，如與肝素結(jié)合能力較弱，以及作為血管生成抑制劑和內(nèi)皮細(xì)胞趨化性抑制劑的作用。試劑盒檢測(cè)范圍為0.625 ng/mL-40 ng/mL，適用于體外科研場(chǎng)景，如探索PF4V1在疾病模型中的表達(dá)調(diào)控機(jī)制、評(píng)估藥物或基因干預(yù)對(duì)血小板活化的影響，或分析不同組織來(lái)源樣本中該因子的動(dòng)態(tài)變化，為細(xì)胞信號(hào)通路研究及生物標(biāo)志物篩選提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書。
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別名：PF4V1 ELISA Kit; CXCL4V1 ELISA Kit; SCYB4V1 ELISA Kit; Platelet factor 4 variant ELISA Kit; C-X-C motif chemokine 4 variant ELISA Kit; CXCL4L1 ELISA Kit; PF4alt ELISA Kit; PF4var1) [Cleaved into: Platelet factor 4 variant(4-74); Platelet factor 4 variant(5-74); Platelet factor 4 variant(6-74)] ELISA Kit
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縮寫：
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Uniprot No.：
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種屬：Homo sapiens (Human)
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樣本類型：serum, plasma, cell culture supernates, tissue homogenates
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檢測(cè)范圍：0.625 ng/mL-40 ng/mL
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靈敏度：0.156 ng/mL
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反應(yīng)時(shí)間：1-5h
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樣本體積：50-100ul
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檢測(cè)波長(zhǎng)：450 nm
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研究領(lǐng)域：Others
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測(cè)定原理：quantitative
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測(cè)定方法：Sandwich
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精密度：
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度：
To assess the linearity of the assay, samples were spiked with high concentrations of human PF4V1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 94 Range % 89-99 1:2 Average % 98 Range % 95-103 1:4 Average % 102 Range % 94-106 1:8 Average % 95 Range % 90-98 -
回收率：
The recovery of human PF4V1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 92 89-95 EDTA plasma (n=4) 99 96-103 -
標(biāo)準(zhǔn)曲線：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
ng/ml OD1 OD2 Average Corrected 40 2.945 3.094 3.020 2.831 20 2.266 2.399 2.333 2.144 10 1.532 1.497 1.515 1.326 5 0.775 0.776 0.776 0.587 2.5 0.453 0.454 0.454 0.265 1.25 0.369 0.341 0.355 0.166 0.625 0.230 0.250 0.240 0.051 0 0.184 0.194 0.189 -
數(shù)據(jù)處理：
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貨期：3-5 working days
引用文獻(xiàn)
- CXCL4L1 May Help Differentiate Benign from Malignant Pulmonary Lesions and Predicts Prognosis of Patients with Lung Cancer L Zhang,Cancer management and research,2022
- Downregulation of serum CXCL4L1 predicts progression and poor prognosis in prostate cancer patients treated by radical prostatectomy Zhang M, et al,Asian journal of andrology,2019
- Heparin-mimicking polyethersulfone Membranes-hemocompatibility, cytocompatibility, antifouling and antibacterial properties Shuang-Si Li. et al,Journal of Membrane Science,2016
- Nanofibrous Heparin and Heparin-mimicking Multilayers as Highly Effective Endothelialization and Antithrombogenic Coatings Nie C et al,Biomacromolecules,2015
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靶點(diǎn)詳情
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功能：Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro).
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基因功能參考文獻(xiàn)：
- Fibstatin and CXCL4L1 cooperate to inhibit endothelial cell proliferation, migration and tubulogenesis in vitro. PMID: 23747987
- fibstatin and CXCL4L1 have cooperative roles in inhibition of tumor invasion in lymph nodes PMID: 23747987
- Structural insight into the novel functional properties of human CXCL4L1. PMID: 23536183
- PF-4var/CXCL4L1 predicts outcome in stable coronary artery disease patients with preserved left ventricular function PMID: 22384011
- both CXCR3A and CXCR3B are implicated in the chemotactic and vascular effects of CXCL4L1. PMID: 20980681
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亞細(xì)胞定位：Secreted.
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蛋白家族：Intercrine alpha (chemokine CxC) family
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數(shù)據(jù)庫(kù)鏈接：
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