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中文名稱：小鼠β細胞素(BTC)酶聯免疫試劑盒
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貨號：CSB-E07307m
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規格：96T/48T
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價格：￥3800/￥2500
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其他：
產品詳情
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產品描述：小鼠β細胞素(BTC)酶聯免疫試劑盒（CSB-E07307m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿,組織勻漿樣本中的BTC含量。試劑盒檢測范圍為62.5 pg/ml-4000 pg/ml，適用于胰腺相關疾病模型研究、組織再生機制探索以及代謝調控實驗，能夠有效支持體外培養細胞、動物模型組織或體液樣本中BTC動態表達的定量分析，為揭示β細胞功能調控網絡提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
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別名：Btc ELISA kit; BcnProbetacellulin [Cleaved into: Betacellulin ELISA kit; BTC)] ELISA kit
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縮寫：
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Uniprot No.：
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種屬：Mus musculus (Mouse)
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樣本類型：serum, plasma,tissue homogenates
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檢測范圍：62.5 pg/ml -4000 pg/ml
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靈敏度：15.6 pg/ml
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反應時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領域：Signal Transduction
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測定原理：quantitative
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測定方法：Sandwich
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數據處理：
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貨期：3-5 working days
引用文獻
產品評價
靶點詳情
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功能：Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
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基因功能參考文獻：
- Betacellulin promotes the proliferation of corneal epithelial stem cells through the phosphorylation of Erk1/Erk2. PMID: 29331377
- The results of this study suggested a novel regulatory role of Btc in axon-Schwann cell interactions involved in myelin formation and nerve repair. PMID: 28139851
- BTC induces expansion of neural stem cells and neuroblasts, and promotes neurogenesis in the olfactory bulb and dentate gyrus. PMID: 22232668
- Betacellulin exerts proliferative activity on beta cells through the activation of ErbB-1 and ErbB-2 receptors PMID: 21897861
- BTC overexpression enhances glucose-induced insulin secretion in Mesenchyma Stem Cells PMID: 20836700
- Betacellulin protects from pancreatitis by activating stress-activated protein kinase. PMID: 20038432
- Excess of betacellulin exerts no deleterious effects on the structure or function of the male reproductive tract in mice. PMID: 19931240
- structure of the BTC gene PMID: 12031500
- Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling. PMID: 12773386
- Mice overexpressing BTC exhibit high early postnatal mortality, reduced body weight gain, impaired longitudinal growth, cataract, retinal and bone abnormalities, and lung disease. PMID: 16179416
- identified hitherto unknown effects of betacellulin (BTC) overabundance in reproduction and suggests BTC as a novel candidate protein for the modulation of fertility. PMID: 17914071
- role of BTC in the regulation of epidermal homeostasis, hair follicle morphogenesis and cycling, and wound angiogenesis PMID: 17960175
- Overexpression of BTC results in an EGFR-dependent upregulation of cortical bone mass in the appendicular skeleton of mice. PMID: 19049329
- Long-term BTC overabundance does not alter pancreatic islet structure and beta-cell mass, but enhances glucose-induced insulin secretion in vivo as well as in vitro. PMID: 19100309
- Reversal of streptozotocin-induced hyperglycemia by continouous supply of Btc. PMID: 19378417
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亞細胞定位：[Betacellulin]: Secreted, extracellular space.; [Probetacellulin]: Cell membrane; Single-pass type I membrane protein.
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組織特異性：Found in several mouse tissues including kidney, uterus and liver, as well as in beta tumor cell line and MCF-7 cells. It is not detected in the brain.
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數據庫鏈接：
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