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中文名稱：大鼠嗜酸粒細胞趨化蛋白Eotaxin 1(Eotaxin 1/CCL11)酶聯免疫試劑盒
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貨號：CSB-E07319r
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規格：96T/48T
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價格：￥3200/￥2500
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其他：
產品詳情
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產品描述：大鼠嗜酸粒細胞趨化蛋白Eotaxin 1(Eotaxin 1/CCL11)酶聯免疫試劑盒（CSB-E07319r）檢測血清、血漿、組織勻漿樣本中的CCL11含量。CCL11是一種重要的靶點。它在免疫調節等生理過程中發揮作用。相關研究關注其在炎癥反應、趨化免疫細胞遷移等機制，探索其在疾病如過敏性疾病、神經系統疾病等發病中的作用，有望為開發針對CCL11的治療手段提供依據。試劑盒檢測范圍為15.6 pg/ml-1000 pg/ml，適用于呼吸道疾病模型研究、炎癥機制探索及藥物干預效果評估等科研場景本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
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別名：Ccl11 ELISA Kit; Scya11Eotaxin ELISA Kit; C-C motif chemokine 11 ELISA Kit; Eosinophil chemotactic protein ELISA Kit; Small-inducible cytokine A11 ELISA Kit
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縮寫：
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Uniprot No.：
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種屬：Rattus norvegicus (Rat)
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樣本類型：serum, plasma, tissue homogenates
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檢測范圍：15.6 pg/ml -1000 pg/ml
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靈敏度：3.9 pg/ml
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反應時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領域：Immunology
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測定原理：quantitative
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測定方法：Sandwich
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精密度：
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線性度：
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回收率：
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標準曲線：
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數據處理：
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貨期：3-5 working days
引用文獻
- Protein tyrosine phosphatase 11 acts through RhoA/ROCK to regulate eosinophil accumulation in the allergic airway Xu C, et al,Faseb Journal,2019
產品評價
相關產品
靶點詳情
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功能：In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils. Binds to CCR3.
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基因功能參考文獻：
- our data suggest that the CCL11-CCR3 interaction mainly activates PI3K/Akt signal transduction pathway in HUVECs. PMID: 28279120
- Iddm30 controls pancreatic expression of Ccl11 (Eotaxin) and the Th1/Th2 balance within the insulitic lesions. PMID: 24646746
- Tripterine can inhibit expression of Eotaxin by restraining the activation of NF-kappaB in the nasal musoca of rats with allergic rhinitis. PMID: 23272499
- expression of Ccl11 associates with immune response modulation in experimental autoimmune encephalomyelitis PMID: 22815714
- Intervention of PRMT1 activity can abrogate IL-4-dependent eotaxin-1 production to influence the pulmonary inflammation with eosinophil infiltration. PMID: 22387551
- The expression of Eotaxin in nasal lavage fluid and nasal mucosa increased after treatment of allergic rhinitis with histamine. PMID: 20359111
- The expression of Eotaxin in nasal mucosa increased, and the expression of CCR3 in bone marrow increased in the model of allergic rhinitis. PMID: 16722399
- Suppression of eotaxin by CpG DNA reduced the symptoms of experimental allergic rhinitis. PMID: 16838745
- Targeting CCL11 with monoclonal antibodies possibly results in decreased myocardial fibrosis and improves contractile function after heart transplantation ub rats. PMID: 20832583
- Galectin-3 inhibited expression of eotaxin and IL5, potentially suppressing eosinophilic inflammation in asthma. PMID: 17074272
- Eotaxin is upregulated in the pancreatic lymph nodes and may play a role in early disease pathogenesis of type 1 diabetes mellitus in the BioBreeding rat model. PMID: 15557196
- In a model of ongoing acute heart transplant rejection in the rat, we found eotaxin mRNA expression within infiltrating macrophages, but not in mast cells PMID: 19631640
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亞細胞定位：Secreted.
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蛋白家族：Intercrine beta (chemokine CC) family
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數據庫鏈接：
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