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中文名稱：大鼠巨噬細胞集落刺激因子(M-CSF)酶聯免疫試劑盒
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貨號：CSB-E07424r
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規格：96T/48T
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價格：￥3900/￥2500
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其他：
產品詳情
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產品描述：大鼠巨噬細胞集落刺激因子(M-CSF)酶聯免疫試劑盒（CSB-E07424r）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養上清液、組織勻漿樣本中的CSF1含量。CSF1即集落刺激因子 1，是一種能刺激單核巨噬細胞前體細胞增殖和分化的細胞因子。其研究機制主要圍繞它與其受體 CSF1R 相互作用展開，在免疫調節、組織修復等方面發揮作用，也和腫瘤微環境形成、炎癥性疾病發生發展有關。試劑盒檢測范圍為0.156 ng/ml- 10 ng/ml，靈敏度為0.039 ng/ml。適用于科研領域中評估大鼠感染模型、自身免疫性疾病研究或藥物干預實驗中M-CSF的動態表達，亦可用于體外培養巨噬細胞功能研究時的細胞因子分泌檢測。實驗操作兼容多種生物樣本類型，配備標準化校準品與緩沖體系，可滿足基礎研究、病理機制探索及生物標志物分析等多元化需求。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
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別名：Csf1 ELISA kit; CsfmMacrophage colony-stimulating factor 1 ELISA kit; CSF-1 ELISA kit; MCSF) [Cleaved into: Processed macrophage colony-stimulating factor 1] ELISA kit
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縮寫：
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Uniprot No.：
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種屬：Rattus norvegicus (Rat)
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樣本類型：serum, plasma, cell culture supernates, tissue homogenates
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檢測范圍：0.156 ng/ml - 10 ng/ml
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靈敏度：0.039 ng/ml
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反應時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領域：Cardiovascular
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測定原理：quantitative
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測定方法：Sandwich
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精密度：
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線性度：
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回收率：
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標準曲線：
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數據處理：
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貨期：3-5 working days
引用文獻
- Mesenchymal Stem Cells and Myeloid-Derived Suppressor Cells Interplay in Adjuvant-Induced Arthritis Rat Model FAM Abo-Aziza,International immunopharmacology,2023
- Reversing Postcardiopulmonary Bypass Associated Cognitive Dysfunction Using k-Opioid Receptor Agonists to Regulate Microglial Polarization via the NLRP3/Caspase-1 Pathway Pei Song,Journal of Healthcare Engineering,2021
- EXPANSION, ACTIVATION AND FUNCTION PROMOTION OF MYELOID-DERIVED SUPPRESSOR CELLS IN ADJUVANT-INDUCED ARTHRITIS Abd-Elhalem S S, et al,European Journal of Biomedical,2019
- Functionalized cerium oxide nanoparticles mitigate the oxidative stress and pro-inflammatory activity associated to the portal vein endothelium of cirrhotic rats Ribera J, et al,Plos One,2019
- Elderly-onset hereditary pulmonary alveolar proteinosis and its cytokine profile Masayuki Ito.et al,BMC Pulmonary Medicine,2017
產品評價
相關產品
靶點詳情
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功能：Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
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相關疾病：A defect in Csf1 is the cause of the toothless phenotype (tl). Toothless rats display osteoclastopenia, severe osteopetrosis, and dystrophic growth plates.
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亞細胞定位：Cell membrane; Single-pass type I membrane protein.; [Processed macrophage colony-stimulating factor 1]: Secreted, extracellular space.
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數據庫鏈接：
STRING: 10116.ENSRNOP00000025221
UniGene: Rn.83632
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