NFKBIB Monoclonal Antibody

中文名稱：

NFKBIB鼠單克隆抗體
貨號(hào)：

CSB-MA191867
規(guī)格：

￥1090
圖片：
Immunohistochemical analysis of paraffin-embedded Human Lung Carcinoma using IκB β(mAb diluted at 1:200.

Immunohistochemical analysis of paraffin-embedded Human Kidney Tissue using IκB βMouse mAb diluted at 1:200.
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
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靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品描述：

CUSABIO貨號(hào)：CSB-MA191867 NFKBIB單克隆抗體是針對(duì)核因子κB抑制蛋白β（NFKBIB/IKBβ）研發(fā)的高特異性科研試劑，適用于人、小鼠、大鼠物種的ELISA和免疫組化（IHC）檢測(cè)。該抗體基于重組蛋白免疫原制備，可特異性識(shí)別NFKBIB蛋白的56-145氨基酸區(qū)域，其作為NF-κB信號(hào)通路關(guān)鍵調(diào)控因子，通過(guò)抑制NF-κB核轉(zhuǎn)位參與炎癥反應(yīng)、免疫應(yīng)答及細(xì)胞增殖等重要生物學(xué)過(guò)程研究。產(chǎn)品經(jīng)過(guò)嚴(yán)格驗(yàn)證，在ELISA實(shí)驗(yàn)中展現(xiàn)高靈敏度的抗原結(jié)合能力，適用于體外定量檢測(cè)；IHC應(yīng)用則支持石蠟或冰凍組織切片中目標(biāo)蛋白的定位分析，為探究NF-κB通路在腫瘤、自身免疫疾病及感染性疾病中的分子機(jī)制提供可靠工具。本產(chǎn)品滿足炎癥機(jī)制研究、信號(hào)轉(zhuǎn)導(dǎo)分析及基因表達(dá)調(diào)控等科研需求，是探索轉(zhuǎn)錄因子動(dòng)態(tài)平衡和細(xì)胞應(yīng)激反應(yīng)的重要試劑。關(guān)鍵詞：NFKBIB單抗、IKBβ檢測(cè)試劑、ELISA抗體、免疫組化試劑、NF-κB通路研究。
Uniprot No.：

Q15653
基因名：

NFKBIB
別名：

I kappa B beta antibody; I-kappa-B-beta antibody; IkappaBbeta antibody; IKB beta antibody; IkB-B antibody; IkB-beta antibody; IKBB antibody; IKBB_HUMAN antibody; IkBbeta antibody; NF kappa BIB antibody; NF-kappa-B inhibitor beta antibody; NF-kappa-BIB antibody; Nfkbib antibody; Thyroid receptor interacting protein 9 antibody; Thyroid receptor-interacting protein 9 antibody; TR interacting protein 9 antibody; TR-interacting protein 9 antibody; TRIP-9 antibody; TRIP9 antibody
宿主：

Mouse
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Recombinant Protein
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
純化方式：

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
克隆號(hào)：

5C3
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
基因功能參考文獻(xiàn)：
1. The subcellular distributions of IkappaB and NFkappaB are indicative of carcinogenesis. Inhibition of XPO1 results in intranuclear retention of IkappaB, which inhibits NFkappaB and thereby provides a novel mechanism for drug therapy in sarcoma. This effect can be further enhanced in relatively selinexor-resistant sarcoma cell lines by pretreatment with the proteasome inhibitor carfilzomib. PMID: 28314790
2. data suggest that miRNA-4776 modulates Influenza A virus production in infected cells through NFKBIB expression, possibly through the modulation of NF-kappaB. PMID: 28448456
3. our data establish the importance of a novel tumor suppressive IKBB gene in abrogating angiogenesis in NPC via the NF-kappaB signalling pathway. PMID: 26227166
4. NFKBIBrs3136641TT single nucleotide polymorphism was associated with a significantly decreased risk of developing wheezing. PMID: 25326706
5. IkappaBbeta may be a novel target for transcription factors of the HMG-box SRY/Sox family and imply a potential role for NF-kappaB/IkappaBbeta in spermatogenesis PMID: 12475944
6. VEGF increased Mn-superoxide dismutase promoter activity, an effect that was dependent on a second intronic NF-kappaB consensus motif. PMID: 15308628
7. data indicate that inhibition of NFkappa-B activity by the hepatitis C virus core protein might be related to its physical interaction with and interrupted nuclear localization of IKKbeta PMID: 15919917
8. None of the NFKBIB SNPs are associated with pneumococcal susceptibility. PMID: 17463416
9. increased I-kappaBbeta expression reversed NF-kappaB activation in cancer cells, compensating for the loss of I-kappaBalpha via TGase 2 polymerization. PMID: 18950638
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亞細(xì)胞定位：

Cytoplasm. Nucleus.
蛋白家族：

NF-kappa-B inhibitor family
組織特異性：

Expressed in all tissues examined.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 7798

OMIM: 604495

KEGG: hsa:4793

STRING: 9606.ENSP00000312988

UniGene: Hs.9731

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