Recombinant Mouse Cadherin-6 (Cdh6), partial (Active)

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貨號：

CSB-MP005055MO1
說明書：

MSDS Datasheet
規格：

￥696
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse CDH6 at 2 μg/ml can bind Anti-CDH6 recombinant antibody (CSB-RA005055MA1HU). The EC₅₀ is 1.884-2.164 ng/mL. Biological Activity Assay
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靶點詳情

產品詳情

純度：

Greater than 95% as determined by SDS-PAGE.
內毒素：

Less than 1.0 EU/ug as determined by LAL method.
生物活性：

Measured by its binding ability in a functional ELISA. Immobilized Mouse CDH6 at 2 μg/mL can bind Anti-CDH6 recombinant antibody (CSB-RA005055MA1HU). The EC50 is 1.884-2.164 ng/mL.
基因名：

CDH6
Uniprot No.：

P97326
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
來源：

Mammalian cell
分子量：

67.8 kDa
表達區域：

19-615aa
氨基酸序列

TFSNPLSKRTSGFPAKRKALELSANSRNELSRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAVNRRTGRPVEPESEFIIKIHDINDNEPIFTKDVYTATVPEMADVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGHEMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPHVEPRFLYLGPFKDSATVRIVVDDVDEPPVFSKLAYILQIREDARINTTIGSVAAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLRAVDKDDPYSGHQFSFSLAPEAASSSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGA
蛋白標簽：

C-terminal 10xHis-tagged
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from a 0.2 μm filtered PBS, 6% Trehalose, pH 7.4
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
基因功能參考文獻：
1. Cadherin 6 expression in the nascent cortical plate may serve solidification of the protomap for cortical functional areas. PMID: 22875867
2. cadherin-6 plays essential roles in locomotor activity and ultrasonic vocalization PMID: 23173049
3. role of cadherin 6 as a novel ligand for alpha(IIb)beta(3) and highlights its function in thrombus formation. PMID: 22539596
4. Data show that during development, the adhesion molecule cadherin-6 is expressed by a subset of retinal ganglion cells and also by their targets in the brain. PMID: 21867880
5. Cadherin 6 is expressed in the floor and roof plates of the motor columns of the spinal cord. PMID: 12139922
6. identified a short 79-bp region that is implicated in regulating expression in cells once they have emigrated from the neural tube PMID: 18234175
7. Results describe the genetic control of Cdh6 expression by systematic integration of a reporter cassette into bacterial artificial chromosomes, with reporter activities evaluated in stable transgenic mouse lines. PMID: 18617008
8. These results suggest the role of Cdh6 in coordinating mouse hindbrain compartments possibly under the control of Hox gene regulatory network. PMID: 18948151
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein.
數據庫鏈接：

KEGG: mmu:12563

STRING: 10090.ENSMUSP00000037113

UniGene: Mm.458225