CHMP6 Antibody

中文名稱：

CHMP6兔多克隆抗體
貨號：

CSB-PA846622LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA846622LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA846622LA01HU at dilution of 1:100

Western Blot
Positive WB detected in: Rat lung tissue
All lanes: CHMP6 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 24 kDa
Observed band size: 24 kDa

Immunohistochemistry analysis of human melanoma using CSB-PA846622LA01HU at dilution of 1:100

Immunohistochemistry analysis of human brain tissue using CSB-PA846622LA01HU at dilution of 1:100
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CHMP6 Polyclonal antibody
Uniprot No.：

Q96FZ7
基因名：

CHMP6
別名：

Charged multivesicular body protein 6 antibody; chmp6 antibody; CHMP6_HUMAN antibody; Chromatin modifying protein 6 antibody; Chromatin-modifying protein 6 antibody; FLJ11749 antibody; hVps 20 antibody; hVps20 antibody; novel SNF7 protein antibody; OTTMUSP00000004363 antibody; RGD1565325 antibody; RP24 225K18.4 antibody; Vacuolar protein sorting associated protein 20 antibody; Vacuolar protein sorting-associated protein 20 antibody; Vps 20 antibody; Vps20 antibody
宿主：

Rabbit
反應種屬：

Human, Rat
免疫原：

Recombinant Human Charged multivesicular body protein 6 protein (2-201AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CHMP6 Antibody (CSB-PA846622LA01HU)，的標記方式是Non-conjugated。對于CHMP6 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA846622LB01HU	CHMP6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA846622LC01HU	CHMP6 Antibody, FITC conjugated
Biotin	CSB-PA846622LD01HU	CHMP6 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.
基因功能參考文獻：
1. Taken together, these data suggest an active role for ESCRT-II and CHMP6 in ESCRT-mediated abscission PMID: 25232011
2. Purified VPS-20 exhibits an open extended conformation, irrespective of ESCRT-II binding. PMID: 25588614
3. silencing CHMP6 and VPS4A also blocked epidermal growth factor receptor (EGFR) recycling PMID: 22231449
4. In this study, we found that overexpression of chromatin modifying protein 6 (CHMP6) induced cell death by a series of experiments. PMID: 19270365
5. Results describe the mapping of multivesicular bodies with the second winged helix domain of human ESCRT-II subunit VPS25 and the first helix of ESCRT-III subunit VPS20. PMID: 19686684
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亞細胞定位：

Endomembrane system. Endosome membrane; Lipid-anchor. Late endosome membrane. Membrane; Lipid-anchor. Note=Localizes to endosomal membranes.
蛋白家族：

SNF7 family
組織特異性：

Ubiquitously expressed.
數據庫鏈接：

HGNC: 25675

OMIM: 610901

KEGG: hsa:79643

STRING: 9606.ENSP00000317468

UniGene: Hs.514560

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