CTSE Antibody
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中文名稱：CTSE兔多克隆抗體
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貨號：CSB-PA237699
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA237699(CTSE Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA237699(CTSE Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200) -
Gel: 8%SDS-PAGE,Lysate: 40 μg,,Primary antibody: CSB-PA237699(CTSE Antibody) at dilution 1/525 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute
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其他：
產品詳情
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Uniprot No.：
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基因名：CTSE
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別名：CATE antibody; CATE_HUMAN antibody; Cathepsin E antibody; Cathepsin E form II antibody; CTSE antibody; Erythrocyte membrane aspartic proteinase antibody; Slow moving proteinase antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Fusion protein of Human CTSE
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 WB 1:500-1:2000 IHC 1:100-1:300 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.
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基因功能參考文獻：
- Cathepsin E, mitochondrial fission, and caspase activation/apoptosis are linked in the pathogenesis of pulmonary emphysema. PMID: 25239563
- High Expression of Cathepsin E is associated with Tissues but Not Blood of Patients with Barrett's Esophagus and Adenocarcinoma. PMID: 25348778
- Decreased activity of cathepsin E produced by decidual macrophages might be responsible for the induction of miscarriages in some recurrent miscarriage patients. PMID: 24464956
- data demonstrate that CatE contributes to normal growth and development of mammary glands through proper trafficking and secretion of Wnt5a PMID: 24242330
- CTSE is a marker of both gastric differentiation and signet-ring cell carcinoma, which should shed light on the mechanism of gastric tumorigenesis. PMID: 23451082
- Cath E activity is useful as a potential molecular target for Pancreatic ductal adenocarcinoma and early detection imaging. PMID: 22068166
- A comparative structure model of splice variant 2 was computed based on its alignment to the known structure of cathepsin E intermediate (Protein Data Bank code 1TZS) and used to rationalize its conformational properties and loss of activity. PMID: 22718633
- Emerging roles of cathepsin E in immune system cells and skin keratinocytes, and in host defense against cancer cells. PMID: 21664991
- Cath E selectivity was established by having -Leu**Pro- residues at the scissile peptide bond. PMID: 20600629
- These results suggest the possible involvement of cathepsin E in disruption of the structural and functional integrity of alpha 2-macroglobulin in the endolysosome system. PMID: 12631277
- Reduced expression of cathepsin E is observed in erythrocytes of humans with atopic dermatitis. PMID: 14769879
- crystal structure of an activation intermediate of cathepsin E at 2.35A resolution PMID: 15342244
- Both cathepsin E message and protein are found in human dendritic cells, but are absent in monocytes. PMID: 15699105
- Three-dimensional structure of cathepsin-E. PMID: 15845357
- the human cathepsin E gene is regulated by the constitutive androstane receptor PMID: 17888866
- cathepsin E differentially regulates the nature and function of dendritic cells and macrophages PMID: 17947645
- cathepsin E plays a substantial role in host defense against tumor cells through TRAIL-dependent apoptosis and/or tumor-associated macrophage-mediated cytotoxicity PMID: 18006832
- CatE is important in the processing of tetanus toxin C-fragment in primary human B cells. PMID: 18996084
- This study demonstrates the over-expression in CTSE, in particular, and TFF1 in sessile serrated adenomas compared to both hyperplastic polyps and tubular adenomas. PMID: 19172291
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亞細胞定位：Endosome. Note=The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.
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蛋白家族：Peptidase A1 family
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組織特異性：Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B-lymphocytes.
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數據庫鏈接：
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