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中文名稱：DSC2兔多克隆抗體
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貨號：CSB-PA007190ESR2HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA007190ESR2HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) DSC2 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：ARVD11 antibody; Cadherin family member 2 antibody; CDHF2 antibody; Desmocollin 3 antibody; Desmocollin-2 antibody; Desmocollin-3 antibody; Desmocollin2 antibody; Desmosomal glycoprotein II and III antibody; Desmosomal glycoprotein II antibody; Desmosomal glycoprotein II/III antibody; Desmosomal glycoprotein III antibody; DG2 antibody; DGII/III antibody; DKFZp686I11137 antibody; DSC 2 antibody; DSC2 antibody; DSC2_HUMAN antibody; DSC3 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Desmocollin-2 protein (520-690AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
引用文獻
- Decreased Expression of Plakophilin-2 and αT-Catenin in Arrhythmogenic Right Ventricular Cardiomyopathy: Potential Markers for Diagnosis PF Hung,International Journal of Molecular Sciences,2022
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靶點詳情
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功能：Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
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基因功能參考文獻：
- Desmocollin-2 genetic variant contributes to Arrhythmogenic Right Ventricular Cardiomyopathy PMID: 27531918
- PKP3 overexpression increases the stability of other desmosomal proteins independently of the increase in DSC2 levels and regulates desmosome formation and stability by a multimodal mechanism affecting transcription, protein stability and cell border localization of desmosomal proteins. PMID: 29146182
- The cardiac specific DSC2 transgenic mice develop severe biventricular cardiomyopathy. PMID: 28339476
- A novel missense mutation (c.1090 G > A/p.V364 M) of DSC2 was identified in a Chinese family with arrhythmogenic right ventricular cardiomyopathy. PMID: 28256248
- Data suggest juxtamembrane regions/domains of desmocollin-2 (DSC2), plakophilin 2 (PKP2), and plakophilin 3 (PKP3) are involved in desmosome formation in epithelial cells; DSC2 participates in desmosome formation in absence of desmoglein 2 (DSG2). PMID: 25972099
- Oxidized low-density lipoprotein attenuated desmoglein 1 and desmocollin 2 expression in human umbilical vein endothelial cells. PMID: 26498522
- DSC2 promoter methylation is associated with Breast Cancer. PMID: 25809865
- Homozygous founder mutation in DSC2 gene identified among Italian arrhythmogenic cardiomyopathy probands, providing evidence of the occurrence of recessive DSC2 mutations presenting with biventricular forms of the disease. PMID: 26310507
- Desmocollin-2 mutations are described for dilated cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy, as well. Desmocollin-2 mutation was described in a case of arrhythmogenic biventricular cardiomyopathy PMID: 25576714
- a novel Nrf2-miR-29-Dsc2 axis controls desmosome function and cutaneous homeostasis PMID: 25283360
- ECG reliably identifies homozygous p.Gln554X desmocollin-2 carriers and may be useful as an initial step in the screening of high-risk Hutterites. PMID: 25497880
- DSC2 may be involved in the regulation of the invasive behavior of cells by a mechanism that controls cellcell attachment and cytoskeleton rearrangement PMID: 25119898
- Data demonstrate that partner desmosomal cadherins Dsg2 and Dsc2 play opposing roles in controlling colonic carcinoma cell proliferation through differential effects on EGFR signaling. PMID: 24166502
- Case of arrhythmogenic right ventricular cardiomyopathy with a previously unreported desmocollin-2 mutation (c.712_714delGAT). This genetic variant displays autosomal recessive inheritance without the cutaneous manifestations. PMID: 24793512
- Reduced cardiac desmoglein-2 and desmocollin-2 levels appear to be specifically associated with Arrhythmogenic right ventricular Dysplasia/cardiomyopathy, independent of underlying mutations. PMID: 24086444
- A homozygous truncation mutation, c.1660C>T (p.Q554X) in desmocollin-2 (DSC2) was idnetified in affected individuals and determined a carrier frequency of this mutation of 9.4% among 1535 Schmiedeleut Hutterites. PMID: 23863954
- DSC2 is a useful immunohistochemical marker for separation of Urothelial carcinoma with squamous differentiation from pure Urothelial carcinoma PMID: 22014052
- The Dsc2 exhibit microtubule-dependent transport in epithelial cells but use distinct motors to traffic to the plasma membrane. PMID: 22184201
- At the molecular level, altered binding properties of the desmocollin-2a mutant may contribute to the changes in connexin43 PMID: 21220045
- Report mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations. PMID: 21062920
- Studies identified two mutations in DSG2, four in DSC2, two in DSP, four in JUP and seven in PKP2. PMID: 20864495
- Desmocollin 2 is involved in the transformation and development of esophageal tumors and that desmocollin 2 expression level and intracellular localization may serve as a predictor for patient outcomes. PMID: 20621329
- DSC2 gene mutations are not frequently involved in arrhythmogenic right ventricular cardiomyopathy/dysplasia. PMID: 20197793
- Mutations in DSG2 and DSC2 are less prevalent than PKP2 mutations in Dutch arrhythmogenic right ventricular dysplasia/cardiomypath patients. PMID: 20031616
- Loss of Dsc2 protein is associated with colorectal cancer PMID: 17088906
- DSC2 mutations are a cause of arrhythmogenic right ventricular cardiomyopathy in humans, physiologic levels of DSC2 are crucial for normal cardiac desmosome formation, early cardiac morphogenesis, and cardiac function. PMID: 17186466
- The two missense mutations in the N-terminal domain affect the normal localisation of DSC2, thus suggesting the potential pathogenic effect of the reported mutations PMID: 17963498
- Mutations in the desmosome genes were identified in four of the five patients (three with a DSG2 mutation and one with a DSP mutation). Five gene mutations were noted in four patients and all mutations were novel (one patient had a DSG2 double mutation). PMID: 18632414
- Repression of the desmocollin 2 gene expression in human colon cancer cells is relieved by the homeodomain transcription factors Cdx1 and Cdx2. PMID: 18819935
- mutation associated with autosomal recessive arrhythmogenic right ventricular cardiomyopathy PMID: 18957847
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相關疾病：Arrhythmogenic right ventricular dysplasia, familial, 11 (ARVD11)
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亞細胞定位：Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
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組織特異性：Expressed in epithelia, myocardium and lymph nodes.
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