GFRA1 Antibody

說明書

中文名稱：

GFRA1兔多克隆抗體
貨號：

CSB-PA008804
規格：

￥1090
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P56159
基因名：

GFRA1
別名：

GDNF family receptor alpha 1 antibody; GDNF family receptor alpha-1 antibody; GDNF R antibody; GDNF RA antibody; GDNF receptor alpha antibody; GDNF receptor alpha-1 antibody; GDNFR alpha 1 antibody; GDNFR alpha antibody; GDNFR antibody; GDNFR-alpha-1 antibody; GDNFRA antibody; GDNFRalpha antibody; GFR alpha 1 antibody; GFR alpha1 antibody; GFR-alpha-1 antibody; GFRA 1 antibody; Gfra1 antibody; GFRA1_HUMAN antibody; GFRalpha1 antibody; Glial cell line derived neurotrophic factor receptor alpha antibody; GPI linked anchor protein antibody; MGC23045 antibody; PI linked cell surface accessory protein antibody; RET 1L antibody; RET ligand 1 antibody; RET1L antibody; RETL 1 antibody; RETL1 antibody; TGF beta related neurotrophic factor receptor 1 antibody; TGF-beta-related neurotrophic factor receptor 1 antibody; TRNR 1 antibody; TRNR1 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human GFRα-1.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:10000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.
基因功能參考文獻：
1. circGFRA1 may function as a competing endogenous RNA (ceRNA) to regulate GFRA1 expression through sponging miR-34a to exert regulatory functions in TNBC. PMID: 29037220
2. the methylation status of CpG sites in GFRA1 and GSTM2 may have a role and could be used as potential biomarkers for the screening of rectal cancer PMID: 27566576
3. GFRA1 regulates AMPK-dependent autophagy by promoting SRC phosphorylation independent of proto-oncogene RET kinase PMID: 27754745
4. that the consequences of this is that GFRalpha-1-mediated signalling is altered during the ageing process PMID: 27346872
5. RET c.1296A may be a common susceptibility allele for nephron underdosing-related diseases. The 5'-UTR and intronic variants near exon 5 of GFRA1 are not associated with nephron endowment. PMID: 27533506
6. Hox proteins coordinate motor neuron differentiation and connectivity programs through Ret/Gfra genes. PMID: 26904955
7. This study demonstrate, using a knock-in mouse model in which GFRalpha1 is no longer located in lipid rafts, that the developmental functions of GDNF in the periphery require the translocation of the GDNF receptor complex into lipid rafts. PMID: 26400951
8. Methylation changes of GFRA1, SRF, and ZNF382 may be a potential biomarker set for prediction of gastric carcinoma metastasis. PMID: 25009298
9. GFRalpha1 levels in neurons from autopsied AD brains are significantly decreased. PMID: 25253858
10. In the cochlea, GFRalpha-1 was identified mainly in the cell bodies of the spiral neurons. In the organ of Corti, GFRalpha-1 was demonstrated in the Deiters' cells, Hensen cells, inner pillar cells, and weakly in inner hair cells but not in the outer hair cells. PMID: 24139947
11. The study shows co-localization of RET with GFRA1 and GFRA2 in myenteric ganglia of the adult human colon. PMID: 23881409
12. The expression of GFRalpha1 and/or GFRalpha3, especially when combined with ARTN expression, may be useful predictors of disease progression and outcome in specific subtypes of mammary carcinoma. PMID: 23351331
13. Mutations in GFRA1 gene is associated with urinary tract malformations. PMID: 22729463
14. Post-synaptic transgenic GFRalpha1 has profound effects on the development of dopamine neurons, resulting in a 40% increase in the adult number. PMID: 21133924
15. This study found nominally-significant evidence for interactions between GFRA1, 2 and 3 associated with schizophrenia and clozapine response, consistent with the locations of these three genes within linkage regions for schizophrenia. PMID: 20116071
16. Results identify persephin, a GDNF family member, as a novel ligand for GFRalpha1/RET receptor complex. PMID: 20350599
17. MEN2 arises from activating missense mutations in RET, causing autodimerization under certain conditions. The position of missense mutations influences medullary thyroid carcinoma aggressiveness. Review. PMID: 20669561
18. Here we report that human nigral dopaminergic neurons express GFRalpha1 and RET receptors at all ages. There was no reduction in the number of neurons expressing these receptors as a function of age. PMID: 20347960
19. GFR-alpha1 mRNA transcripts were detected in oocytes and GCs from all samples from fetuses, girls and adult women. PMID: 19896648
20. The expression of GFRA1 in normal infants and normoganglionic colon of patients with Hirschsprung's disease was restricted to receptor tyrosine kinase(RET)-negative glial cells and RET-positive neurons of the ganglionic plexus. PMID: 12065680
21. GFRA1-193C > G and 537T > C could be in linkage disequilibrium with other loci responsible for medullary thyroid cancer PMID: 12490080
22. analysis of binding surface for the GDNF-GFR alpha 1 PMID: 14514671
23. GFRalpha-1 were observed within sensory and motor nuclei of cranial nerves, dorsal column nuclei, olivary nuclear complex, reticular formation, pontine nuclei, locus caeruleus, raphe nuclei, substantia nigra, and quadrigeminal plate. PMID: 17825269
24. GDNF can act as an important component of the inflammatory response in breast cancers and its effects aare mediated by GFR alpha 1 receptors. PMID: 18089803
25. GDNF is a key component to preserve several cell populations in the nervous system and also participates in the survival and differentiation of peripheral neurons. PMID: 18394855
26. 38 cases of germ cell tumors: 26 cases contained immature teratoma, of which 24 had immature neuroepithelium and showed strong membrane staining for GFRalpha-1. staining for GFRalpha-1 in immature neuroepithelium may facilitate its identification. PMID: 19019765
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亞細胞定位：

Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus, trans-Golgi network. Endosome. Endosome, multivesicular body.
蛋白家族：

GDNFR family
數據庫鏈接：

HGNC: 4243

OMIM: 601496

KEGG: hsa:2674

STRING: 9606.ENSP00000393725

UniGene: Hs.388347

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