HOXC4 Antibody

說明書

產品詳情

Uniprot No.：

P09017
基因名：

HOXC4
別名：

CP 19 antibody; CP19 antibody; Homeo box 3E antibody; Homeo box C4 antibody; Homeo box protein HoxC4 antibody; Homeobox 3E antibody; Homeobox C4 antibody; Homeobox protein CP19 antibody; Homeobox protein Hox C4 antibody; Homeobox protein Hox-3E antibody; Homeobox protein Hox-C4 antibody; Homeobox protein HoxC4 antibody; Homeobox3E antibody; HomeoboxC4 antibody; HOX 3 antibody; Hox 3E antibody; HOX C4 antibody; HOX3 antibody; Hox3E antibody; HOXC 4 antibody; Hoxc4 antibody; HXC4_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human HOXC4
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
基因功能參考文獻：
1. HOXC4 homeoprotein expands human hematopoietic immature cells by 3 to 6 times ex vivo and significantly improves the level of in vivo engraftment. PMID: 22298821
2. Human cytomegalovirus downregulates while all-trans retinoic acid upregulates expression of hoxc4 and hoxc6 in lymphocytic progenitor cells. PMID: 19236766
3. Esr1 bind to and activate the HOXC4 promoter to potentiate HoxC4-mediated AID induction, immunoglobulin class switch and somatic hypermutation. PMID: 20855884
4. Selective inhibition of class switching to IgG and IgE by recruitment of this and Oct-1 proteins and Ku70/Ku86 to newly identified ATTT cis-elements. PMID: 12672812
5. The hs1,2mediated enhancement of V(H) and C(H) promoter-driven transcription as induced by HoxC4 and Oct-1/Oct-2 suggests an important role of these homeodomain proteins in the overall regulation of the IgH locus expression. PMID: 15252056
6. The HOXC4 expression was clearly detected in all inv(7) positive patients. PMID: 15674412
7. HoxC4 directly activates the Aicda promoter PMID: 19363484
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亞細胞定位：

Nucleus.
蛋白家族：

Antp homeobox family, Deformed subfamily
數據庫鏈接：

HGNC: 5126

OMIM: 142974

KEGG: hsa:3221

STRING: 9606.ENSP00000305973

UniGene: Hs.549040

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