Maged1 Antibody
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中文名稱：Maged1兔多克隆抗體
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貨號：CSB-PA234148
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規(guī)格：￥2024
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圖片：
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Western blot analysis of extracts from PC12 cells using Melanoma-associated antigen D1 Antibody and the same antibody preincubated with blocking peptide.
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Mus musculus (Mouse) Maged1 Polyclonal antibody
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Uniprot No.：
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基因名：
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宿主：Rabbit
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反應(yīng)種屬：Mouse,Rat
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免疫原：Peptide with sequence C-EAEARAEARNRMGIGDE derived from Mouse Melanoma-associated antigen D1.
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免疫原種屬：Mus musculus (Mouse)
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克隆類型：Polyclonal
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純化方式：Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
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濃度：It differs from different batches. Please contact us to confirm it.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:1000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA coregulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.
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基因功能參考文獻(xiàn)：
- Both transient and stable expression of Necdin induced osteoblast-specific markers in an osteogenic cell line through formation of a complex with melanoma-associated antigen D1 (MAGE-D1) and promoter activation. PMID: 28528976
- MAGED1 as a novel regulator of osteoblastogenesis, osteoclastogenesis, and bone remodeling in a mouse model PMID: 26272363
- Maged1 deficiency prevented the interaction of Maged1 with cAMP response element-binding protein (CREB). PMID: 24700102
- NRAGE is a potent regulator of proliferation and odontoblastic differentiation of mouse dental pulp cells, which might be via the NF-kappaB signalling pathway. PMID: 25736627
- Show Ror2 expression is higher in highly metastatic cell line than in low metastatic variant cell line. Our data show that Ror2 is a potential factor in the tumorigenesis and metastasis in a Src-dependent manner that is negatively regulated by NRAGE. PMID: 23142633
- We conclude that Maged1 is required for OT processing or stability. A decrease in mature OT levels in Maged1 mutants affects social interactions and possibly other behavioral processes PMID: 22865874
- Maged1 is involved in osteoblast proliferation and differentiation. Mice deficient in Maged1 protein had decreased bone mineral density (BMD) PMID: 23300464
- the present findings suggest a novel role for MAGE-D1 in depressive behaviors: modulating SERT ubiquitylation. PMID: 22457503
- XIAP-TAB1-TAK1 complex is dependent on NRAGE for IKK-alpha/beta phosphorylation and NF-kappaB activation. PMID: 21789165
- MAGED1 binds to nuclear receptor RORalpha to bring about positive and negative effects on core clock genes of Bmal1, Rev-erbalpha and E4bp4 expression through the Rev-Erbalpha/ROR responsive elements (RORE). PMID: 20300063
- NRAGE induces NF-kappaB activation and MIF expression in P19 cells PMID: 20100315
- MHD2 of NRAGE was not necessary for BMP-induced p38MAPK activation or caspase-mediated apoptosis. PMID: 19937275
- roles for NRAGE as a mediator of precursor apoptosis and a repressor of cell cycle progression in neural development PMID: 12204258
- receptor tyrosine kinase-like orphan receptor 2(Ror2) sequesters Dlxin-1 in membranous compartments, thereby affecting the transcriptional function of Mhomeobox, msh-like 2(msx2) PMID: 12754255
- The expression pattern of Maged1 roughly summarizes that of Maged2 and Maged3 PMID: 15162511
- necdin and MAGE-D1 cooperate to modulate the function of Dlx/Msx homeodomain proteins in cellular differentiation PMID: 15272023
- Our results suggest that interaction of cytosolic PrP and NRAGE could affect neuronal viability. PMID: 15911347
- NRAGE as an integral component in bone morphogenetic proteins signaling and clarify its role during neural progenitor development PMID: 16107717
- NRAGE plays an important role in apoptotic-signaling in vivo. PMID: 18772898
- NRAGE might have multiple roles during renal branching morphogenesis through association with both the BMP and GDNF signaling pathways. PMID: 19268530
- The netrin receptor UNC5H1 induces apoptosis through and interaction with NRAGE. PMID: 12598531
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亞細(xì)胞定位：Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein.
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組織特異性：Ubiquitously expressed in many adult tissues, except for the spleen. Expressed in osteoblastic and chondrogenic cell lines and also during embryonic development.
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