NFKBIE (Ab-22) Antibody
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中文名稱：NFKBIE (Ab-22)兔多克隆抗體
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貨號：CSB-PA148874
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規格：￥2024
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圖片：
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Western blot analysis of extracts from Hela, 293 and HepG2 cells using IkB-e(Ab-22) Antibody. -
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IkB-e(Ab-22) Antibody(left) or the same antibody preincubated with blocking peptide(right).
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) NFKBIE Polyclonal antibody
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Uniprot No.：
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基因名：
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Peptide sequence around aa. 20~24 (I-E-S-L-R) derived from Human IkB-e.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:1000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.
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基因功能參考文獻：
- identify NFKBIE aberrations as a common genetic event across B-cell malignancies and highlight NFKBIE deletions as a novel poor-prognostic marker in PMBL. PMID: 27670424
- We suggest that the impairment of NFKBIE gene function can reduce the uptake of methotrexate into cells, suggesting that the gene is an important factor for rheumatoid arthritis outcome PMID: 26587663
- A NFKBIE polymorphism was associated with increased risk of pneumococcal meningitis. PMID: 26870821
- results show that Gal-1 acts by inhibiting the stimulation of the LPS-induced IkappaBzeta expression, an NF-kappaB regulator involved in IL-6 gene transcription. PMID: 26226212
- Newly identified alterations included recurrent promoter mutations of NFKBIE, encoding NF-kappaB inhibitor varepsilon (IkappaBvarepsilon), in 14.5% of samples of desmoplastic melanoma PMID: 26343386
- Vitamin C forestalls cigarette smoke induced NF-kappaB activation in alveolar epithelial cells. PMID: 23615073
- we identified two gene loci associated with rheumatoid arthritis susceptibility- NFKBIE and RTKN2 PMID: 23028356
- Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon PMID: 16769727
- An NFKBIE SNP associated with susceptibility to pneumococcal disease but not pneumococcal empyema. PMID: 17463416
- Expression levels of GGT1 and possibly NFKBIE might be useful as biomarkers of genetic susceptibility to arsenite. PMID: 17976673
- Genomic mutation of the NFKBIE gene in primary Hodgkin/ Reed Sternberg cells PMID: 14595753
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亞細胞定位：Cytoplasm.
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蛋白家族：NF-kappa-B inhibitor family
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組織特異性：Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages.
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數據庫鏈接：
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