PARP3 Antibody, HRP conjugated
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中文名稱：PARP3兔多克隆抗體, HRP偶聯
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貨號：CSB-PA017467EB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PARP3 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：ADP ribosyltransferase (NAD+, poly (ADP ribose) antibody; ADP ribosyltransferase diphtheria toxin like 3 antibody; ADPRT-3 antibody; ADPRT3 antibody; ADPRTL2 antibody; ADPRTL3 antibody; ARTD3 antibody; hPARP 3 antibody; hPARP-3 antibody; hPARP3 antibody; IRT 1 antibody; IRT1 antibody; NAD(+) ADP ribosyltransferase 3 antibody; NAD(+) ADP-ribosyltransferase 3 antibody; NAD+ ADP ribosyltransferase 3 antibody; pADPRT 3 antibody; pADPRT-3 antibody; pADPRT3 antibody; PARP 3 antibody; PARP-3 antibody; PARP3 antibody; PARP3_HUMAN antibody; Poly (ADP ribose) polymerase family, member 3 antibody; Poly (ADP ribose) synthetase 3 antibody; Poly [ADP-ribose] polymerase 3 antibody; Poly[ADP ribose] synthetase 3 antibody; Poly[ADP-ribose] synthase 3 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Poly [ADP-ribose] polymerase 3 protein (1-240AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage. Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks. Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ). Cooperates with the XRCC5-XRCC6 (Ku80-Ku70) heterodimer to limit end-resection thereby promoting accurate NHEJ. Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as XRCC5 and XRCC6. ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks. Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA /AID on the chromatin.
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基因功能參考文獻：
- These data identify PARP3 as a molecular sensor of nicked nucleosomes. PMID: 27530147
- PARP3 controls of TGFbeta-induced epithelial mesenchymal transformation and acquisition of stem-like cell features by stimulation transglutaminase 2/SNAI1 signaling. PMID: 27579892
- Data indicate that PARP3, a DNA damage-activated ADP-ribosyltransferase, can mono-ADP-ribosylate double-stranded DNA ends. PMID: 29054115
- In a process of single-strand DNA repair, PARP3 mono-ADP-ribosylates nucleosomal histone H2B. PMID: 27716488
- we found that PARP3 interacted with FoxM1 to enhance its transcriptional activity and conferred glioblastoma cell radioresistance. Thus, our data suggest that PARP3 could be a therapeutic target to overcome radioresistance in glioblastoma PMID: 26040766
- Identification of ADP-ribosylation sites in PARP3 and the determination of the extent ofpoly(ADP-ribosyl)ated residues in this protein was performed. PMID: 25800440
- MiR-630 reduced apoptosis by downregulating several apoptotic modulators, PARP3, DDIT4, and EP300. PMID: 25255219
- In some cancer cells, repression of PARP3 could be responsible for an increased telomerase activity. PMID: 24528514
- PARP3 likely facilitates the recruitment of Ku80 to double strand breaks to antagonize DNA end resection but facilitate Ku-mediated accurate classical non-homologous end-joining. PMID: 24598253
- PARP3 gene occupancy in the human neuroblastoma cell line SK-N-SH occurs preferentially with developmental genes regulating cell fate specification, tissue patterning, craniofacial development and neurogenesis. PMID: 21264220
- PARP3 is a critical player in the stabilization of the mitotic spindle and in telomere integrity by associating and regulating the mitotic components NuMA and tankyrase 1. PMID: 21270334
- PARP-3 has a role in chromosomal DNA double-strand break repair. PMID: 21211721
- the interaction between PARP-1 and PARP-3 is unrelated to DNA single-strand break repair PMID: 20064938
- PARP-3 is a nuclear protein involved in transcriptional silencing and in the cellular response to DNA damage PMID: 16924674
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亞細胞定位：Nucleus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
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組織特異性：Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.
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