THOP1 Antibody
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中文名稱：THOP1兔多克隆抗體
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貨號：CSB-PA023508GA01HU
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規(guī)格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：EC 3.4.24.15 antibody; Endopeptidase 24.15 antibody; EP24.15 antibody; MEPD_HUMAN antibody; MP78 antibody; Thimet oligopeptidase 1 antibody; Thimet oligopeptidase antibody; Thop1 antibody; THOP1_HUMAN antibody; TOP antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human THOP1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments.
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基因功能參考文獻：
- Data suggest that three new candidate genes involved in the development of rheumatoid arthritis (RA): ERBB2, TP53 and THOP1. PMID: 28148290
- THOP1 may have clinical potentials to be employed as a promising biomarker to identify individuals with better prognosis and a novel antitumor agent for therapy of patients with NSCLC PMID: 25180910
- Low THOP1 expression levels are associated with recurrence of hepatocellular carcinoma. PMID: 24604581
- TCEP. Data indicate that THIMET-oligopeptidase (TOP) oxidation by H2O2 and high valence states of hemeproteins does not lead to enzyme oligomerization. PMID: 24223886
- shear-dependent TOP induction down-regulates MHC1 levels, pointing to a role for TOP in the flow-mediated regulation of endothelial immunogenicity PMID: 23708739
- The semi-quantitative intracellular peptidome analyses of siRNA-transfected HEK293 cells shows that the levels of specific intracellular peptides are either increased or decreased upon EP24.15 inhibition. PMID: 22796113
- mediates antigen processing that generates cytotoxic T cell epitopes PMID: 21151101
- human thimet oligopeptidase crystal structure shows substrate recognition, regulation, and localization PMID: 14998993
- THIMET has a role in degradation of peptides generated by proteasomes PMID: 15328361
- EP24.15 associates with AT1 and B2 receptors both at the plasma membrane and after receptor internalization PMID: 15376229
- Mutations at only two residues (Glu-469 and Arg-498) are required to swap specificity with neurolysin, a result that is confirmed by testing the two-mutant constructs. PMID: 17251185
- increase in THOP1 expression might be part of a compensatory defense mechanism of the brain against an increased Abeta load. PMID: 18571100
- Over 100 peptides were identified in human embryonic kidney 293 (HEK293) cells that are derived from intracellular proteins; many but not all of these peptides are substrates or products of EP24.15. PMID: 19282285
- interaction between EP24.15 and calmodulin is regulated within cells and is important for the stimulated secretion of EP24.15 from HEK293 cells. PMID: 19614740
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亞細胞定位：Cytoplasm.
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蛋白家族：Peptidase M3 family
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數(shù)據(jù)庫鏈接：
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