KIR3DL2 Recombinant Monoclonal Antibody

說明書

中文名稱：

KIR3DL2重組抗體
貨號：

CSB-RA012365MA1HU
規格：

￥1320
圖片：
The Binding Activity of Human KIR3DL2 with Anti-KIR3DL2 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human KIR3DL2(CSB-MP012365HU1) at 2 μg/mL can bind Anti-KIR3DL2 recombinant antibody , the EC₅₀ is 14.18-23.93 ng/mL.

Untransfected HEK-293T cells (green line) and transfected Human KIR3DL2 HEK-293T stable cells (red line) were stained with anti-KIR3DL2 recombinant antibody (2μg/1*10⁶cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
其他：

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靶點詳情

產品詳情

產品描述：

CSB-RA012365MA1HU是靶向KIR3DL2蛋白的重組單克隆抗體，專為科研領域設計。KIR3DL2屬于殺傷細胞免疫球蛋白樣受體家族，主要表達于自然殺傷（NK）細胞和特定T細胞亞群表面，通過識別HLA-A3/A11等MHC-I類分子參與免疫應答調控，在感染性疾病、腫瘤免疫逃逸及自身免疫調控機制研究中具有重要價值。本抗體通過ELISA平臺嚴格驗證，展現高親和力與優異特異性，可精準識別天然及重組KIR3DL2蛋白，適用于體外樣本中靶蛋白的定性與定量檢測。其應用場景涵蓋免疫學基礎研究，例如探究KIR3DL2在NK細胞功能調控、病原體免疫監視或腫瘤微環境中的作用機制，也可作為工具抗體用于開發體外檢測體系，支持疾病模型構建或藥物靶點篩選等實驗需求。該產品采用重組表達技術生產，批次穩定性高，為科研工作者提供可靠的分析工具。
Uniprot No.：

P43630
基因名：

KIR3DL2
別名：

KIR3DL2 Recombinant Monoclonal Antibody
反應種屬：

Human
免疫原：

Recombinant Human KIR3DL2 protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

hIgG1
純化方式：

Affinity-chromatography
克隆號：

8D10
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, FC

推薦稀釋比：

Application	Recommended Dilution
FC	1:20-1:200

Protocols：

ELISA Protocol
Flow cytometry (FC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Receptor on natural killer (NK) cells and T cells for MHC class I molecules. Upon binding of peptide-free HLA-F open conformer, negatively regulates NK and T cell effector functions. Acts as a receptor on astrocytes for HLA-F. Through interaction with HLA-F, may protect motor neurons from astrocyte-induced toxicity.
基因功能參考文獻：
1. We show that KIR3DL2 expression is the most sensitive diagnostic criterion of Sezary syndrome when compared with all other available biological criteria. KIR3DL2 therefore represents a valuable tool for routine use as a clinical parameter at diagnosis, for prognosis and during patient follow-up PMID: 28119365
2. results identified significant KIR3DL2 expression in all cutaneous T-cell lymphomas subtypes PMID: 29089310
3. Overexpression of a single MHCI molecule, HLA-F, protects human MNs from ALS astrocyte-mediated toxicity, whereas knockdown of its receptor, the killer cell immunoglobulin-like receptor KIR3DL2, on human astrocytes results in enhanced motor neurons death PMID: 26928464
4. KIR-3DL2 binding to HLA-B27 licenses Th17 cell differentiation in spondyloarthritis. PMID: 26841353
5. In early axial spondyloarthritis and ankylosing spondylitis Dutch patients, no copy number changes were found for KIR3DL2. PMID: 25940819
6. we show that the allele KIR3DL2*001 and the single nucleotide polymorphism 1190T (rs3745902) are associated with differential susceptibility to pemphigus PMID: 25867094
7. CD158k expression was identified on cutaneous CD4+ T cells in healthy individuals and also mycosis fungoides patients. PMID: 25044837
8. These findings provide novel insights about the molecular basis of KIR3DL2 binding to B27 PMID: 25582852
9. these data provide evidence for a possible role of KIR3DL2 in the maintenance of a high circulating malignant-cell burden by preventing activation-induced cell death. PMID: 25414436
10. Our results indicate that KIR3DL2 can directly promote Sezary syndrome malignant cell death through the use of CpG ODN. PMID: 25007046
11. our results show that a multistep gating of CD158k+ cells is reliable to assess tumor burden in case of Sezary syndrome. PMID: 25158034
12. our results offer preclinical proof of concept for the clinical development of IPH4102, a humanized monoclonal antibody that targets the immune receptor KIR3DL2,to treat patients with nced cutaneous T-cell lymphoma PMID: 25361998
13. KIR3DL2 binds to HLA-B27 dimers and free H chains more strongly than other HLA class I and promotes the expansion of T cells in ankylosing spondylitis. PMID: 23440420
14. PLS3, Twist, KIR3DL2 and NKp46 gene expression can model efficient molecular Sezary syndrome diagnosis. PMID: 23429988
15. most frequently expressed KIR receptor in transformed mycosis fungoides PMID: 22621189
16. results suggest that carriers of A allele in exon 3 of killer cell immunoglobulin-like receptor 3DL2(KIR3DL2) have a decreased susceptibility to preeclampsia PMID: 21406041
17. Enhanced proliferation, survival, and interleukin (IL)-17 production of KIR3DL2+ CD4 T cells stimulated with antigen-presenting cells expressing HLA-B27 homodimers suggest new therapeutic strategies in ankylosing spondylitis. PMID: 21248258
18. Data show direct binding of KIR3DL2 to ODNs and we show that the D0 domain is involved primarily in this interaction. PMID: 20147700
19. The A52G polymorphism in exon 3 and the frequencies of C32T in exon 9 of KIR3DL2 gene polymorphism are associated with the pathogenesis of pre-eclampsia. PMID: 19953898
20. All genotypes seen included genes for KIR3DL2. PMID: 12559621
21. IR3DL2/p140 engagement does not result into inhibitory (nor activatory) effects on tumor-specific cytotoxic T lymphocytes. PMID: 14562047
22. A high level of KIR3DL2 allelic polymorphism has been identified. PMID: 15304002
23. Receptor is a marker for the diagnosis of Sezary syndrome. PMID: 16962036
24. Five new alleles are reported, and four previously known ones are confirmed. PMID: 17661911
25. observation that CD4 positive, CD7 negative T-cells are mostly CD158k negative suggests that CD158k may be able to help identify and enumerate neoplastic T-cells in Sezary syndrome PMID: 18061949
26. Functional analysis of KIR3DL2-single positive natural killer (NK) cells reveals a subset that is hyporesponsive in individuals harboring cognate ligands HLA-A3/A11. PMID: 18941190
27. Anti-p140 autoantibodies represent a major autoantibody subset in juvenile dermatomyositis. PMID: 19479859
28. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. PMID: 19165527
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein.
蛋白家族：

Immunoglobulin superfamily
組織特異性：

Expressed in astrocytes.
數據庫鏈接：

HGNC: 6339

OMIM: 604947

KEGG: hsa:3812

STRING: 9606.ENSP00000325525

UniGene: Hs.645228

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