Recombinant Dog Cell division control protein 42 homolog (CDC42)

中文名稱：

Recombinant Dog Cell division control protein 42 homolog(CDC42)
貨號：

CSB-YP005008DO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Dog Cell division control protein 42 homolog(CDC42)
貨號：

CSB-EP005008DO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Dog Cell division control protein 42 homolog(CDC42)
貨號：

CSB-EP005008DO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Dog Cell division control protein 42 homolog(CDC42)
貨號：

CSB-BP005008DO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Dog Cell division control protein 42 homolog(CDC42)
貨號：

CSB-MP005008DO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

CDC42
Uniprot No.：

P60952
別名：

CDC42Cell division control protein 42 homolog; EC 3.6.5.2; G25K GTP-binding protein
種屬：

Canis familiaris (Dog) (Canis lupus familiaris)
蛋白長度：

Full length protein
表達區域：

1-188
氨基酸序列

MQTIKCVVVG DGAVGKTCLL ISYTTNKFPS EYVPTVFDNY AVTVMIGGEP YTLGLFDTAG QEDYDRLRPL SYPQTDVFLV CFSVVSPSSF ENVKEKWVPE ITHHCPKTPF LLVGTQIDLR DDPSTIEKLA KNKQKPITPE TAEKLARDLK AVKYVECSAL TQKGLKNVFD EAILAALEPP EPKKSRRC
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling. Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups.
基因功能參考文獻：
1. Rab14 knockdown results in increased Cdc42 activity mediated through Arf6. PMID: 27901125
2. Silencing tight junction protein ZO-2 alters epithelial cytoarchitecture.ZO-2 silencing increases RhoA activity through GEF-H1 recruitment to cell borders.ZO-2 silencing activates Cdc42 and triggers mitotic spindle disorientation. ZO-2 silencing increases Rac1 and cofilin activity and lamellipodia formation. PMID: 28554775
3. CDC42 regulates anoikis. PMID: 15093747
4. Cdc42 activation regulates active tension development and actin polymerization during smooth muscle contractile stimulation PMID: 15456777
5. CrkII plays a critical role in the regulation of N-WASp activation, actin polymerization, and active tension generation in tracheal smooth muscle, by regulating the activation of cdc42 [CrkII] PMID: 15834156
6. these results provide the first evidence for a role of Rac1/Cdc42 signalling during early HSV-1 infection and suggest a mechanism relying on virus-induced regulation of Rac1/Cdc42 activities. PMID: 17098962
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亞細胞定位：

Cell membrane; Lipid-anchor; Cytoplasmic side. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, dendrite.
蛋白家族：

Small GTPase superfamily, Rho family, CDC42 subfamily
數據庫鏈接：

KEGG: cfa:403934

STRING: 9615.ENSCAFP00000021683

UniGene: Cfa.39956