Recombinant Mouse Crk-like protein (Crkl)

中文名稱：

Recombinant Mouse Crk-like protein(Crkl)
貨號：

CSB-YP005980MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Crk-like protein(Crkl)
貨號：

CSB-EP005980MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Crk-like protein(Crkl)
貨號：

CSB-EP005980MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Crk-like protein(Crkl)
貨號：

CSB-BP005980MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Crk-like protein(Crkl)
貨號：

CSB-MP005980MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Crkl
Uniprot No.：

P47941
別名：

Crkl; CrkolCrk-like protein
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達區域：

1-303
氨基酸序列

MSSARFDSSD RSAWYMGPVT RQEAQTRLQG QRHGMFLVRD SSTCPGDYVL SVSENSRVSH YIINSLPNRR FKIGDQEFDH LPALLEFYKI HYLDTTTLIE PAPRYPSPPV GSVSAPNLPT AEENLEYVRT LYDFPGNDAE DLPFKKGELL VIIEKPEEQW WSARNKDGRV GMIPVPYVEK LVRSSPHGKH GNRNSNSYGI PEPAHAYAQP QTTTPLPTVA STPGAAINPL PSTQNGPVFA KAIQKRVPCA YDKTALALEV GDIVKVTRMN INGQWEGEVN GRKGLFPFTH VKIFDPQNPD DNE
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

May mediate the transduction of intracellular signals.
基因功能參考文獻：
1. CRKL plays an important role in hepatocarcinoma cell proliferation, invasion and migration as well hepatocarcinoma malignancy and metastasis. PMID: 25960220
2. CRKL is shown to act as a potential suppressor and to provide new insight for both the malignant behaviors of hepatocarcinoma cells and lymphatic metastasis mechanism of hepatocarcinoma. PMID: 25661331
3. Sprouty2 acts as an inhibitor of CrkL-Rap1 signaling. PMID: 20136656
4. The molecular signaling set off by ERalpha and CrkL association may have a central role in pregnancy and cancer. PMID: 21700719
5. Reelin-induced Dab1 tyrosine phosphorylation may generate a multifaceted signaling scaffold containing a rich array of Crk/CrkL-SH3 binding effectors PMID: 21879738
6. CrkL plays a specific role in integrin-induced migration as a downstream mediator of Src. PMID: 12665586
7. CrkL is not absolutely required for T cell development or function. PMID: 14515252
8. These results suggest a role for CrkL in the Reelin signaling pathway to control neuronal migration. PMID: 17394141
9. Crkol is essential for cranial and cardiac neural crest development. The chromosomal location of the human CRKL gene (22q11.21) and the phenotype of Crkol mutant mice suggest that defects in CRKL-mediated pathways underlie DiGeorge syndrome. PMID: 11242111
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蛋白家族：

CRK family
數據庫鏈接：

KEGG: mmu:12929

STRING: 10090.ENSMUSP00000006293

UniGene: Mm.21048