Recombinant Mouse Peptidyl-prolyl cis-trans isomerase D (Ppid)

中文名稱：

小鼠Ppid重組蛋白
貨號：

CSB-YP866598MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Ppid重組蛋白
貨號：

CSB-EP866598MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Ppid重組蛋白
貨號：

CSB-EP866598MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Ppid重組蛋白
貨號：

CSB-BP866598MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Ppid重組蛋白
貨號：

CSB-MP866598MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ppid
Uniprot No.：

Q9CR16
別名：

Ppid; Peptidyl-prolyl cis-trans isomerase D; PPIase D; EC 5.2.1.8; 40 kDa peptidyl-prolyl cis-trans isomerase; Cyclophilin-40; CYP-40; Rotamase D
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

2-370
氨基酸序列

SHASPAAKP SNSKNPRVFF DVDIGGERVG RIVLELFADI VPKTAENFRA LCTGEKGTGS TTGKPLHFKG CPFHRIIKKF MIQGGDFSNQ NGTGGESIYG EKFEDENFHY KHDREGLLSM ANAGPNTNGS QFFITTVPTP HLDGKHVVFG QVIKGLGVAR TLENVEVNGE KPAKLCVIAE CGELKEGDDW GIFPKDGSGD SHPDFPEDAD IDLKDVDKIL LISEDLKNIG NTFFKSQNWE MAIKKYAKVL RYVDSSKAVI EKADRSRLQP IALSCVLNIG ACKLKMSNWQ GAIDSCLEAL EMDPSNTKAL YRKAQGWQGL KEYDQALADL KKAQEIAPGD KAIQAELLKV KQMIKAQKDK EKAVYAKMFA
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity region. Involved in regulation of UV radiation-induced apoptosis.
基因功能參考文獻：
1. stimulates mitochondrial permeability transition pore excessive opening, causing endoplasmic reticulum stress through p38 mitogen-activated protein kinase activation, resulting in enhanced sterol regulatory element-binding protein-1c transcription and hepatic steatosis PMID: 29356058
2. Data suggest that mitochondrial functions in osteoblasts during osteogenesis are regulated, in part, by CypD-mPTP axis; CypD appears to contribute to mitochondrial dysfunction in bone inflammation via excessive opening of mPTP. (CypD = cyclophilin D; mPTP = mitochondrial permeability transition pore) PMID: 29679227
3. CypD regulates complex I-induced ROS production in heart mitochondria and modulates the cardioprotective effect of isoflurane, sevoflurane, and desflurane. PMID: 28328748
4. Murine eosinophil necrosis is regulated in vitro and in vivo by cyclophilin D. PMID: 26893161
5. Suggest that cyclosporin A-mediated CypD inhibition may provide a promising therapeutic potential for protecting retinal ganglion cells against ischemic injury-mediated mitochondrial dysfunction. PMID: 24603333
6. Loss of CypD results in changes in a number of mitochondrial proteins and metabolic pathways. PMID: 23262437
7. CypD directs mitochondria-to-nuclei inflammatory gene expression in normal and tumor cells PMID: 23303179
8. BAX/BAK-independent cell death did not require Cyclophilin D (CypD) expression, an important regulator of the mitochondrial permeability transition pore PMID: 22719850
9. At the whole muscle level, lack of cyclophilin-D does not protect against muscle atrophy, release of mitochondrial pro-apoptotic factors and activation of caspases following denervation. PMID: 21224232
10. mitochondrial permeability transition was increased by hypoxia-reoxygenation but was less in normoxic and hypoxia-reoxygenation Ppif(-/-) than wild type tubules PMID: 21490135
11. These findings point to a possible role of immunophilin signal transduction pathways in astrocytic modulation of neuronal activity at the tripartite synapse. PMID: 21163525
12. Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury. PMID: 20942566
13. Complex contribution of cyclophilin D to Ca2+-induced permeability transition in brain mitochondria, with relation to the bioenergetic state. PMID: 21173147
14. these data suggest that CypD-dependent mitochondrial permeability transition does not play a major role in neurodegeneration in mnd2 mice. PMID: 20123086
15. the permeability transition pore can form and open in the absence of CyP-D, which is the target for PTP inhibition by Cyclosporin A PMID: 15792954
16. implicate pathological activation of the mitochondrial permeability transition pore in the axonal damage occurring during multiple sclerosis and identify CyPD, as well as the permeability transition pore PMID: 17463082
17. suggest a novel CypD-dependent negative-feedback mechanism regulating arterial thrombosis PMID: 17989312
18. Cyclophilin D-dependent (CyD) mitochondrial permeability transition (CyD-mPT) plays an important role in glutamate-triggered delayed calcium deregulation (DCD) and excitotoxic neuronal death. PMID: 19236863
19. In the absence of Cyp-D, Col6a1(-/-) mice show negligible myofiber degeneration, rescue from mitochondrial dysfunction, and normalized incidence of apoptosis. PMID: 19293339
20. CyPD association to the lateral stalk of ATP synthase modulates the activity of the complex PMID: 19801635
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亞細胞定位：

Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm.
蛋白家族：

Cyclophilin-type PPIase family, PPIase D subfamily
數據庫鏈接：

KEGG: mmu:67738

STRING: 10090.ENSMUSP00000029382

UniGene: Mm.295252