Recombinant Mouse Platelet-derived growth factor subunit A (Pdgfa)
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中文名稱：小鼠Pdgfa重組蛋白
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貨號：CSB-EP017708MO-B
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說明書：
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規格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產品詳情
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純度：>85% (SDS-PAGE)
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基因名：
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Uniprot No.：
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別名：PdgfaPlatelet-derived growth factor subunit A; PDGF subunit A; PDGF-1; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide
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種屬：Mus musculus (Mouse)
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蛋白長度：Full Length of Mature Protein
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表達區域：87-211
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氨基酸序列SIEE AVPAVCKTRT VIYEIPRSQV DPTSANFLIW PPCVEVKRCT GCCNTSSVKC QPSRVHHRSV KVAKVEYVRK KPKLKEVQVR LEEHLECACA TSNLNPDHRE EETGRRRESG KNRKRKRLKP T
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蛋白標簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式：Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產品評價
靶點詳情
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功能：Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB.
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基因功能參考文獻：
- PDGF-A signaling is involved in myofibroblast proliferation and migration. PMID: 29636361
- These studies uncover PI3K/AKT2 as a direct PDGFA target that is activated in adipocyte stem cells. PMID: 27746098
- stronger fibrotic effect generated by Platelet-derived growth factor alpha overexpression was mediated by Platelet-derived growth factor receptor alphalpha in cardiac interstitial mesenchymal cells PMID: 27816607
- PDGF-AA impairs endothelium-dependent vasodilation and PDGF-AA mediates BMP4-induced adverse effect on endothelial cell function through SMAD1/5- and SMAD4-dependent mechanisms. PMID: 26769046
- Both cell proliferation and hair inductive activity in murine DPCs are maintained by the synergistic effect of fibroblast growth factor 2 and platelet-derived growth factor receptor alpha. PMID: 25975959
- Primary high invasive Glioma initiating cells SU3 contribute to transformation of adjacent normal host glial cells in local tumor microenvironment possibly via PDGF/PDGFR signaling activation. PMID: 26049020
- Platelet-derived growth factor mediates interleukin-13-induced collagen I production in mouse airway fibroblasts. PMID: 25116623
- senescent cells have a role in optimal wound healing through secretion of PDGF-AA PMID: 25499914
- leading to a PDGF-responsive SRF-driven transcriptional program in the midface PMID: 25453829
- Platelet-derived growth factor plays an integral role in mediating TGF-beta1-dependent mesenchymal stem cell stiffening. PMID: 24093435
- GPIbalpha blockade reverses production of interleukin (IL)-1alpha by microglia in response to cerebral ischemia in animals with Streptococcus pneumoniae infection. PMID: 24644058
- these data uncover an early role of PDGF signaling in primitive endoderm cell survival. PMID: 23733391
- PDGFA-long isoform plays a critical role in normal development of the lung, intestine, and vertebral column. PMID: 23938297
- study examined lung fibroblasts (LF) to learn whether PDGFRalpha expression distinguished a population of precursor cells with enhanced proliferative and migratory capabilities; PDGF-A and Shh both increased cytokinesis and chemotaxis of LF but through different mechanisms PMID: 23748534
- Nuclear localization of FoxO3a, an important regulator of p27(kip1) gene-expression, correlates with diminished proliferation of the PDGFRalpha-expressing LF subpopulation. PMID: 23819440
- Pdgf signaling potentiates Wnt2-Wnt7b signaling to promote high levels of Wnt activity in mesenchymal progenitors that is required for proper development of endoderm-derived organs, such as the lung PMID: 22949635
- These results suggest that PDGF functions as a positive regulator in the final differentiation phase of tongue muscle cells in mouse embryos. PMID: 22264326
- the serum-induced increase in cell surface GLUT4 levels is not due to inhibition of its internalization and is not mediated by insulin, PDGF, IGF-1, or HGF PMID: 21187969
- PDGF protects neurons from H2O2-induced cytotoxicity, and that PI-3K/Akt and MAPK pathways are involved in the protective effects; PDGF-BB exerted more potent neuroprotective effects than PDGF-AA PMID: 19998489
- PDGF-A/PDGF alpha-receptor signaling required for lung growth and the formation of alveoli but not for early branching of the lung epithelium PMID: 11803579
- PDGF signaling through the alpha receptor is an important event downstream of Sry in testis organogenesis and Leydig cell differentiation PMID: 12651897
- PDGF system is highly expressed in the epididymis and suggest that PDGF could be involved in the maintenance of morphological structure and functional control of this organ. PMID: 14522834
- PDGF controls c-myc expression through a JNK- and AP-1-dependent signaling pathway PMID: 14523011
- In vitro cultures supporting the spontaneous generation of functional cardiac myocytes from murine BMCs demonstrated induced expression of PDGF-A and -B. PDGF-AB enhances the generation of BMC-derived cardiac myocytes in mouse hearts. PMID: 14963008
- PDGFRalpha and PDGFA are critical regulators for the continued epithelial-mesenchymal interaction during tooth and palate morphogenesis PMID: 15543606
- PDGF regulates gene expression through a Src Family Kinase-secific pathway that is distinct from the Ras-MAPK and PI3K pathways, and SFKs signal gene expression by enhancing mRNA stability PMID: 15637050
- thrombospondin-1 is not necessary for proliferation but is permissive for vascular smooth muscle cell responses to platelet-derived growth factor PMID: 15890262
- the complete PDGF-A/PDGFR-alpha signaling system is present in murine reproductive tissues, but the distribution of the long and short isoforms of PDFG-A differs PMID: 15932761
- loss of FSH-R signaling causes an imbalance of PDGF family members predisposing the abnormal ovarian follicular environment for inducing tumorigenesis in aging FORKO mice PMID: 16344272
- FGF and PDGF have roles in cell proliferation and migration in osteoblastic cells PMID: 17852407
- One mechanism accounting for the PDGF induction of Glut4 translocation is the suppression of the Munc18c negative regulation of Syntaxin 4 function. PMID: 17916632
- study identified PDGF-A as a candidate epicardium-derived secreted mitogen PMID: 18297729
- During kidney development, PDGFR beta-mediated reactive oxygen species generation and Ca(2+) influx suppress PDGF AA-induced chemotaxis in metanephric mesenchyme. PMID: 19019919
- These results imply a central role of NFI-C in the interplay of the two signaling pathways and in regulation of the progression of tissue regeneration. PMID: 19752192
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亞細胞定位：Secreted. Note=Released by platelets upon wounding.
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蛋白家族：PDGF/VEGF growth factor family
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組織特異性：Expression primarily localized in papillary regions with presumable expression in tubular cells comprising the loop of Henle. In the renal cortex, a widespread expression seen in the vascular smooth muscle cells and is barely detectable in interstitial ce
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