Recombinant Mouse TNF receptor-associated factor 5 (Traf5)

中文名稱：

小鼠Traf5重組蛋白
貨號：

CSB-YP024153MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Traf5重組蛋白
貨號：

CSB-EP024153MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Traf5重組蛋白
貨號：

CSB-EP024153MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Traf5重組蛋白
貨號：

CSB-BP024153MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Traf5重組蛋白
貨號：

CSB-MP024153MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Traf5
Uniprot No.：

P70191
別名：

Traf5; TNF receptor-associated factor 5
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達(dá)區(qū)域：

1-558
氨基酸序列

MAHSEEQAAV PCAFIRQNSG NSISLDFEPD TEYQFVEQLE ERYKCAFCHS VLHNPHQTGC GHRFCQQCIR SLRELNSVPI CPVDKEVIKP QEVFKDNCCK REVLNLHVYC KNAPGCNARI ILGRFQDHLQ HCSFQAVPCP NESCREAMLR KDVKEHLSAY CRFREEKCLY CKRDIVVTNL QDHEENSCPA YPVSCPNRCV QTIPRARVNE HLTVCPEAEQ DCPFKHYGCT VKGKRGNLLE HERAALQDHM LLVLEKNYQL EQRISDLYQS LEQKESKIQQ LAETVKKFEK ELKQFTQMFG RNGTFLSNVQ ALTSHTDKSA WLEAQVRQLL QIVNQQPSRL DLRSLVDAVD SVKQRITQLE ASDQRLVLLE GETSKHDAHI NIHKAQLNKN EERFKQLEGA CYSGKLIWKV TDYRVKKREA VEGHTVSVFS QPFYTSRCGY RLCARAYLNG DGSGKGTHLS LYFVVMRGEF DSLLQWPFRQ RVTLMLLDQS GKKNHIVETF KADPNSSSFK RPDGEMNIAS GCPRFVSHST LENSKNTYIK DDTLFLKVAV DLTDLEDL
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.
基因功能參考文獻(xiàn)：
1. TRAF5 is crucially involved in OSM-mediated lung inflammation probably by inducing lung stromal/fibroblast cell activation. PMID: 29596835
2. our data indicate that Berberine exerts protective effects against chronic renal failurepartly through the TRAF5-mediated activation of the NF-kappaB signaling pathway in mouse podocytes PMID: 29115406
3. The results indicated that TRAF5 deficiency significantly aggravated DSS-induced colitis, most likely by regulating Th cell-mediated inflammation. PMID: 27110068
4. In conclusion, our results suggest that as an intrinsic cardioprotective factor, TRAF5 plays a crucial role in the development of cardiac hypertrophy through the negative regulation of the MEK-ERK1/2 pathway PMID: 24038435
5. knock-out mice develop exaggerated experimental autoimmune encephalomyelitis due to enhanced Th17 cell differentiation PMID: 24681564
6. TRAF5 negatively regulates TLR signaling in B lymphocytes. PMID: 24259503
7. These results provide the first demonstration that TRAF5 is a critical mediator of brain ischemia/reperfusion in an experimental stroke model. PMID: 23413803
8. Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF). PMID: 21822258
9. TNF receptor-associated factor 5 (TRAF5) deficiency accelerates atherogenesis in mice by increasing inflammatory cell recruitment and foam cell formation. PMID: 20651286
10. Study is the first report showing a major requirement for TRAF5 in signaling by a specific receptor both in vitro and in vivo, as well as playing an important role in biological function in B lymphocytes. PMID: 19805155
11. role in both RANKL- and TNFalpha-induced osteoclastogenesis PMID: 12619928
12. TRAF5 has a role in TNF-alpha induced IKK phosphorylation of NF-kappaB p65 PMID: 12842894
13. TRAF5 plays a limiting role during the differentiation of type 2 helper (Th2) cells by limiting certain responses driven by costimulatory molecules such as OX40/CD134. PMID: 15034043
14. Traf5 is a critical intermediate of costimulatory signaling pathways triggered by glucocorticoid-induced TNFR in T-lymphocytes. PMID: 16452475
15. TRAF5 as an important positive signaling element that enhances T cell expansion and pathogen containment by providing a survival advantage to responding Ag-specific CD8(+) T cells during infection. PMID: 19017969
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亞細(xì)胞定位：

Cytoplasm. Cytoplasm, cytosol.
蛋白家族：

TNF receptor-associated factor family, A subfamily
數(shù)據(jù)庫鏈接：

KEGG: mmu:22033

UniGene: Mm.380491