CCL17
CCL17，全稱為C-C motif chemokine ligand 17，也被稱為胸腺活化調(diào)節(jié)趨化因子（TARC），是CC趨化因子家族中的一員。它在人體內(nèi)主要表達于胸腺，并在植物血凝素（PHA）刺激的外周血單個核細(xì)胞中瞬時表達。CCL17通過與T細(xì)胞表面的CCR4受體結(jié)合，在免疫細(xì)胞的遷移、激活和炎癥反應(yīng)的調(diào)節(jié)中發(fā)揮重要作用。研究發(fā)現(xiàn)，CCL17在多種炎癥和免疫相關(guān)疾病中發(fā)揮作用，如哮喘、骨關(guān)節(jié)炎、多發(fā)性骨髓瘤等。針對CCL17及其受體的藥物研發(fā)已取得一定進展，例如阻斷CCL17可減輕小鼠膝骨關(guān)節(jié)炎疼痛和關(guān)節(jié)損傷，提示其在疾病治療中的潛在應(yīng)用價值。
熱銷產(chǎn)品
Recombinant Human C-C motif chemokine 17 (CCL17) (Active) (CSB-MP856406HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Anti-CCL17 recombinant antibody (CSB-RA856406MA1HU) at 2 μg/ml can bind Human CCL17 protein. The EC50 is 2.403-2.741 ng/mL.
CCL17 Recombinant Monoclonal Antibody (CSB-RA856406MA1HU)
驗證數(shù)據(jù)
The Binding Activity of Human CCL17 with Anti-CCL17 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Anti-CCL17 recombinant antibody at 2 μg/mL can bind Human CCL17 protein (CSB-MP856406HU) . The EC50 is 2.403-2.741 ng/mL.
The Binding Activity of Macaca mulatta CCL17 with Anti-CCL17 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Anti-CCL17 recombinant antibody at 2 μg/mL can bind Mouse Ccl17 protein (CSB-MP6512MO). The EC50 is 0.9792-1.486 ng/mL.
The Binding Activity of Macaca mulatta CCL17 with Anti-CCL17 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Anti-CCL17 recombinant antibody at 2 μg/mL can bind Macaca mulatta CCL17 protein (CSB-MP811562MOW). The EC50 is 1.953-2.469 ng/mL.
Overlay Peak curve showing Raji cells stained with CSB-RA856406MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was Fluorescein (FITC) AffiniPure Goat Anti-Human IgG, Fcγ fragment specific at 1:200 dilution for 35 min at 4℃.Control antibody (green line) was human IgG1 (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
Human thymus activation regulated chemokine,TARC ELISA Kit (CSB-E09257h)
驗證數(shù)據(jù)
貨號：CSB-E09257h
規(guī)格：96T/48T
靈敏度：3.9 pg/mL
檢測范圍：15.6 pg/mL-1000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
CCL17 Antibodies
CCL17 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA113746 | CCL17 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA174494 | CCL17 Antibody | Human | ELISA,WB,IHC |
| CSB-PA856406LA01HU | CCL17 Antibody | Human | ELISA, IHC |
| CSB-PA856406LB01HU | CCL17 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA856406LC01HU | CCL17 Antibody, FITC conjugated | Human | |
| CSB-PA856406LD01HU | CCL17 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA856406MA1HU | CCL17 Recombinant Monoclonal Antibody | Human, Mouse, Macaca fascicularis | ELISA, FC |
CCL17 Proteins
CCL17 Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP811562MOW CSB-EP811562MOW CSB-BP811562MOW CSB-EP811562MOW-B |
Recombinant Macaca mulatta C-C motif chemokine 17 (CCL17) | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CCL17 Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP815510CA CSB-EP815510CA CSB-BP815510CA CSB-MP815510CA CSB-EP815510CA-B |
Recombinant Cat C-C motif chemokine 17 (CCL17) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL17 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP856406HU CSB-EP856406HU CSB-BP856406HU |
Recombinant Human C-C motif chemokine 17 (CCL17) | Yeast E.coli Baculovirus |
| CSB-AP000611HU | Recombinant Human C-C motif chemokine 17 protein (CCL17) | E.Coli |
| CSB-MP856406HU | Recombinant Human C-C motif chemokine 17 (CCL17) (Active) | Mammalian cell |
| CSB-EP856406HU-B | Recombinant Human C-C motif chemokine 17 (CCL17), Biotinylated | E.coli |
CCL17 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-BP856825DO |
Recombinant Dog C-C motif chemokine 17 (CCL17) | Baculovirus |
| CSB-EP856825DO | Recombinant Dog C-C motif chemokine 17 (CCL17) | E.coli |
CCL17 ELISA Kit
CCL17 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09257h | Human thymus activation regulated chemokine,TARC ELISA Kit | serum, plasma, tissue homogenates | 3.9 pg/mL |
CCL17 ELISA Kit for Monkey
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL004780RH | Monkey C-C motif chemokine 17(CCL17) ELISA kit | serum, plasma, tissue homogenates | 9.8 pg/mL |
CCL17 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E17792c | Canine thymus activation regulated chemokine(TARC/CCL17)ELISA Kit | serum, plasma, tissue homogenates | 5.86 pg/mL |
