CCL20
CCL20蛋白全稱為C-C基序趨化因子配體20，又名巨噬細(xì)胞炎性蛋白-3α（MIP-3α）或肝臟活化調(diào)節(jié)趨化因子（LARC）。這種蛋白主要由上皮細(xì)胞和免疫細(xì)胞分泌，能夠特異性結(jié)合CCR6受體，引導(dǎo)淋巴細(xì)胞、樹突狀細(xì)胞等向炎癥部位或黏膜組織遷移。在腸道、皮膚等屏障組織中，CCL20通過維持免疫監(jiān)視功能參與病原體清除，但其過度表達(dá)會(huì)引發(fā)慢性炎癥，與銀屑病、潰瘍性結(jié)腸炎等疾病密切相關(guān)。近年來研究發(fā)現(xiàn)，該蛋白在腫瘤微環(huán)境中異常活躍，尤其在結(jié)直腸癌、胰腺癌中可促進(jìn)免疫抑制和腫瘤轉(zhuǎn)移。
針對(duì)CCL20-CCR6軸的藥物開發(fā)已取得進(jìn)展，多個(gè)單克隆抗體和小分子抑制劑進(jìn)入臨床前研究階段。其中一款人源化抗體通過阻斷CCL20與受體結(jié)合，在銀屑病動(dòng)物模型中顯著減輕皮膚病變。另有研究嘗試將該通路抑制劑與免疫檢查點(diǎn)療法聯(lián)用，用于增強(qiáng)抗腫瘤效果。值得注意的是，部分天然產(chǎn)物如姜黃素也被證實(shí)能下調(diào)CCL20表達(dá)，為開發(fā)植物來源的抗炎藥物提供了新思路。
熱銷產(chǎn)品
Recombinant Human C-C motif chemokine 20 (CCL20), partial (CSB-EP004784HU1c0)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗(yàn)證數(shù)據(jù)
Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200
Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200
Immunohistochemical analysis of paraffin-embedded human-pancreas, antibody was diluted at 1:200
Immunohistochemical analysis of paraffin-embedded human-pancreas, antibody was diluted at 1:200
CCL20 Antibodies
CCL20 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA389153 | CCL20 Antibody | Human,Mouse | IHC,ELISA |
CCL20 Proteins
CCL20 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004784HU CSB-EP004784HU CSB-BP004784HU CSB-MP004784HU CSB-EP004784HU-B |
Recombinant Human C-C motif chemokine 20 (CCL20) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP004784HU1 | Recombinant Human C-C motif chemokine 20 (CCL20), partial | E.coli |
| CSB-AP000931HU | Recombinant Human C-C motif chemokine 20 protein (CCL20) | E.Coli |
| CSB-EP004784HU1c0 | Recombinant Human C-C motif chemokine 20 (CCL20), partial | E.coli |
CCL20 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004784RA CSB-EP004784RA CSB-BP004784RA CSB-MP004784RA CSB-EP004784RA-B |
Recombinant Rat C-C motif chemokine 20 (Ccl20) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL20 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004784MO CSB-EP004784MO CSB-BP004784MO CSB-MP004784MO CSB-EP004784MO-B |
Recombinant Mouse C-C motif chemokine 20 (Ccl20) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP001331MO | Recombinant Mouse C-C motif chemokine 20 protein (Ccl20) | E.Coli |
CCL20 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP840478BO | Recombinant Bovine C-C motif chemokine 20 (CCL20) | Yeast |
| CSB-EP840478BO | Recombinant Bovine C-C motif chemokine 20 (CCL20) | E.coli |
| CSB-BP840478BO CSB-MP840478BO CSB-EP840478BO-B |
Recombinant Bovine C-C motif chemokine 20 (CCL20) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL20 ELISA Kit
CCL20 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04667h | Human Macrophage Inflammatory Protein-3α,MIP-3α ELISA kit | serum, plasma, cell culture supernates | 3.9 pg/mL |
CCL20 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04668m | Mouse Macrophage Inflammatory Protein 3α,MIP-3α ELISA kit | serum, plasma, tissue homogenates | 9.75 pg/ml |
CCL20 ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04669r | Rat macrophage inflammatory protein 3α,MIP-3α ELISA Kit |
