CD14

CD14蛋白全稱為單核細胞分化抗原CD14，也被稱作MY23、LeuM3或p55，是一種錨定在細胞膜表面的糖蛋白，主要分布于單核細胞、巨噬細胞及中性粒細胞表面。CD14作為脂多糖（LPS）的高親和力受體，能夠識別并結合細菌內毒素，通過與TLR4受體形成復合物激活下游免疫應答。在感染過程中，CD14通過TLR4/MyD88依賴的信號通路觸發NF-κB等轉錄因子活化，誘導TNF-α、IL-6等促炎因子釋放，參與膿毒癥、慢性炎癥性疾病的發展。臨床研究發現，CD14基因多態性與動脈粥樣硬化、阿爾茨海默病及類風濕性關節炎等疾病風險相關，其表達水平在膿毒癥患者血液中顯著升高，已成為感染性休克的潛在生物標志物。針對CD14的抗體藥物（如IC14）已進入臨床試驗階段，用于中和內毒素引發的過度炎癥反應，同時基于TLR4-CD14信號軸的小分子抑制劑也在探索治療自身免疫性疾病的新策略。

熱銷產品

Recombinant Human Monocyte differentiation antigen CD14 (CD14) (CSB-MP004879HU)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CD14 Recombinant Monoclonal Antibody (CSB-RA004879MA1HU)

驗證數據

IHC image of CSB-RA004879MA1HU diluted at 1：100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

The Binding Activity of Human CD14 with Anti-CD14 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD14 (CSB-MP004879HU1) at 2 μg/mL on an Nickel Coated plate can bind Anti-CD14 recombinant antibody. The EC₅₀ is 2.148-2.447 ng/mL.

CD14 Antibody

CD14 Protein

CD14 ELISA Kit

CD14 Antibodies

CD14 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA004879GA01HU	CD14 Antibody	Human	ELISA,WB,IHC
CSB-MA004879A0m	CD14 Monoclonal Antibody	Human, Mouse, Rabbit	ELISA, WB, IF, FC
CSB-PA07085A0Rb	CD14 Antibody	Human	ELISA, IHC, IF
CSB-PA07085B0Rb	CD14 Antibody, HRP conjugated	Human	ELISA
CSB-PA07085C0Rb	CD14 Antibody, FITC conjugated	Human
CSB-PA07085D0Rb	CD14 Antibody, Biotin conjugated	Human	ELISA
CSB-MA004879A1m	CD14 Monoclonal Antibody	Human, Mouse, Rat, Rabbit	ELISA, WB, IF
CSB-MA792948	CD14 Monoclonal Antibody	Human	ELISA, IHC
CSB-RA004879MA1HU	CD14 Recombinant Monoclonal Antibody	Human	ELISA, IHC

CD14 Proteins

CD14 Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP004879MO CSB-EP004879MO CSB-BP004879MO CSB-MP004879MO CSB-EP004879MO-B	Recombinant Mouse Monocyte differentiation antigen CD14 (Cd14)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD14 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP004879HU CSB-BP004879HU CSB-EP004879HU-B	Recombinant Human Monocyte differentiation antigen CD14 (CD14)	Yeast Baculovirus In Vivo Biotinylation in E.coli
CSB-EP004879HU	Recombinant Human Monocyte differentiation antigen CD14 (CD14)	E.coli
CSB-MP004879HU	Recombinant Human Monocyte differentiation antigen CD14 (CD14)	Mammalian cell

CD14 Proteins for Oryctolagus cuniculus (Rabbit)

產品貨號	產品名稱	來源
CSB-YP638942RB CSB-EP638942RB CSB-BP638942RB CSB-MP638942RB CSB-EP638942RB-B	Recombinant Rabbit Monocyte differentiation antigen CD14 (CD14)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD14 Proteins for Rattus norvegicus (Rat)

產品貨號	產品名稱	來源
CSB-YP737216RA CSB-EP737216RA CSB-BP737216RA CSB-MP737216RA CSB-EP737216RA-B	Recombinant Rat Monocyte differentiation antigen CD14 (Cd14)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD14 Proteins for Bos taurus (Bovine)

產品貨號	產品名稱	來源
CSB-YP839154BO CSB-EP839154BO CSB-BP839154BO CSB-MP839154BO CSB-EP839154BO-B	Recombinant Bovine Monocyte differentiation antigen CD14 (CD14)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli