CD276
CD276，別名B7H3、B7-H3、4Ig-B7-H3，是一種I型跨膜蛋白，屬于B7家族成員之一，主要表達于抗原呈遞細胞表面。
其作用機制涉及與T細胞共刺激分子家族成員相互作用，激活或抑制T細胞的活化與增殖。CD276既可以作為共刺激因子促進T細胞激活、增殖和細胞因子分泌，也可能在某些適應性免疫應答中起到共抑制作用，使腫瘤逃避免疫反應和抑制NK細胞介導的細胞裂解。
CD276在多種腫瘤中表達，并與腫瘤的發(fā)生、侵襲和轉移有關，是一種重要的免疫檢查點分子和潛在的腫瘤免疫治療靶點。
熱銷產品
Recombinant Human CD276 antigen (CD276), partial (Active) (CSB-MP733578HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized CD276 at 2 μg/ml can bind Anti-CD276 rabbit monoclonal antibody, the EC50 of human CD276 protein is 1.961-2.243 ng/ml.
Recombinant Macaca fascicularis CD276 molecule(CD276),partial (Active) (CSB-MP5140MOV)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus CD276 at 2 μg/ml can bind Anti-CD276 recombinant antibody(CSB-RA733578MA1HU). The EC50 is 4.299-5.373 ng/mL.
The purity of CD276 was greater than 90% as determined by SEC-HPLC
CD276 Recombinant Monoclonal Antibody (CSB-RA733578MA1HU)
驗證數(shù)據(jù)
The Binding Activity of Human CD276 with Anti-CD276 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized human CD276(CSB-MP5140MOV) at 2 μg/mL can bind Anti-CD276 recombinant antibody. The EC50 is 4.299-5.373 ng/mL.
The Binding Activity of Human CD276 with Anti-CD276 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized human CD276(CSB-MP733578HU(F2)) at 2 μg/mL can bind Anti-CD276 recombinant antibody. The EC50 is 47.12-54.16 ng/mL.
Overlay Peak curve showing MCF7 cells stained with CSB-RA733578MA1HUMA1HU (red line) at 1:100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-human IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was human IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
CD276 Antibodies
CD276 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA004912GA01HU | CD276 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA005320 | CD276 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA745871ESR1HU | CD276 Antibody | Human | ELISA, WB, IHC |
| CSB-PA745871ESR2HU | CD276 Antibody | Human | ELISA, IHC |
| CSB-RA733578MA1HU | CD276 Recombinant Monoclonal Antibody | Human, Cynomolgus | ELISA, FC |
CD276 Proteins
CD276 Proteins for Xenopus laevis (African clawed frog)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP731567XBE CSB-EP731567XBE CSB-BP731567XBE CSB-MP731567XBE CSB-EP731567XBE-B |
Recombinant Xenopus laevis CD276 antigen homolog (cd276), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD276 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP733578HU CSB-EP733578HU CSB-BP733578HU CSB-EP733578HU-B |
Recombinant Human CD276 antigen (CD276), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP733578HU | Recombinant Human CD276 antigen (CD276), partial (Active) | Mammalian cell |
| CSB-MP733578HU-B | Recombinant Human CD276 antigen (CD276), partial, Biotinylated | Mammalian cell |
| CSB-MP733578HU(F2) | Recombinant Human CD276 antigen (CD276), partial (Active) | Mammalian cell |
| CSB-MP733578HU(A4)f4 | Recombinant Human CD276 antigen (CD276)-VLPs | Mammalian cell |
CD276 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP745871RA CSB-EP745871RA CSB-BP745871RA CSB-MP745871RA CSB-EP745871RA-B |
Recombinant Rat CD276 antigen (Cd276), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD276 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP848693MO CSB-EP848693MO CSB-BP848693MO CSB-EP848693MO-B |
Recombinant Mouse CD276 antigen (Cd276), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CD276 ELISA Kit
CD276 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E14285h | Human Soluble CD276,sCD276/sB7-H3 ELISA Kit | serum, plasma, urine, cell culture supernates | 0.78 ng/mL |
