CD38

CD38全稱為分化簇38，也被稱為ADP-核糖環(huán)化酶或T10抗原，是一種廣泛分布于免疫細(xì)胞表面的II型跨膜糖蛋白。CD38通過催化煙酰胺腺嘌呤二核苷酸（NAD+）生成環(huán)腺苷二磷酸核糖（cADPR）和腺苷二磷酸核糖（ADPR），在細(xì)胞代謝調(diào)控、鈣離子信號傳導(dǎo)及免疫應(yīng)答中發(fā)揮核心作用。其高表達(dá)特征常見于多發(fā)性骨髓瘤、淋巴瘤等血液系統(tǒng)惡性腫瘤，同時也與系統(tǒng)性紅斑狼瘡、類風(fēng)濕關(guān)節(jié)炎等自身免疫性疾病密切相關(guān)。
近年來CD38已成為血液腫瘤治療的重要靶點(diǎn)，達(dá)雷妥尤單抗（Darzalex）作為首個靶向CD38的單克隆抗體，通過抗體依賴細(xì)胞介導(dǎo)的細(xì)胞毒作用（ADCC）和補(bǔ)體依賴的細(xì)胞毒作用（CDC）顯著改善了多發(fā)性骨髓瘤患者的生存預(yù)后。緊隨其后的Isatuximab（Sarclisa）也在全球范圍內(nèi)獲批上市。目前針對該靶點(diǎn)的創(chuàng)新療法持續(xù)涌現(xiàn)，包括CD38-CAR-T細(xì)胞療法、雙特異性抗體等新型免疫治療策略已進(jìn)入臨床試驗(yàn)階段，同時在實(shí)體瘤治療領(lǐng)域的應(yīng)用探索也在積極推進(jìn)。

熱銷產(chǎn)品

Recombinant Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38), partial (CSB-EP004929HU2)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CD38 Recombinant Monoclonal Antibody (CSB-RA796695A0HU)

驗(yàn)證數(shù)據(jù)

Western Blot
Positive WB detected in: THP-1 whole cell lysate
All lanes: CD38 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 35, 14 kDa
Observed band size: 42 kDa

IHC image of CSB-RA796695A0HU diluted at 1:100 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

IHC image of CSB-RA796695A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CD38 Antibody

CD38 Protein

CD38 ELISA Kit

CD38 Antibodies

CD38 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA004929ESR1HU	CD38 Antibody	Human	ELISA, IHC
CSB-PA005628	CD38 Antibody	Human	WB, ELISA
CSB-PA134528	CD38 Antibody	Human	ELISA,WB
CSB-PA926996	CD38 Antibody	Human	ELISA,WB,IHC
CSB-MA785760	CD38 Monoclonal Antibody	Human	ELISA, IHC
CSB-RA796695A0HU	CD38 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC

CD38 Proteins

CD38 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004929MO1 CSB-EP004929MO1 CSB-BP004929MO1 CSB-MP004929MO1 CSB-EP004929MO1-B	Recombinant Mouse ADP-ribosyl cyclase 1 (Cd38), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004929MO	Recombinant Mouse ADP-ribosyl cyclase 1 (Cd38)	in vitro E.coli expression system

CD38 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP722775MOV CSB-EP722775MOV CSB-BP722775MOV CSB-MP722775MOV CSB-EP722775MOV-B	Recombinant Macaca fascicularis ADP-ribosyl cyclase 1 (CD38), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD38 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP731039RA CSB-EP731039RA CSB-BP731039RA CSB-MP731039RA CSB-EP731039RA-B	Recombinant Rat ADP-ribosyl cyclase 1 (Cd38), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD38 Proteins for Oryctolagus cuniculus (Rabbit)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP889007RB CSB-EP889007RB CSB-BP889007RB CSB-MP889007RB CSB-EP889007RB-B	Recombinant Rabbit ADP-ribosyl cyclase 1 (CD38), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD38 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-CF004929HU	Recombinant Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)	in vitro E.coli expression system
CSB-EP004929HU1 CSB-BP004929HU1 CSB-EP004929HU1-B	Recombinant Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38), partial	E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-MP004929HU1	Recombinant Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38), partial	Mammalian cell
CSB-YP004929HU1	Recombinant Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38), partial (Active)	Yeast
CSB-EP004929HU2	Recombinant Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38), partial	E.coli