CX3CL1
CX3CL1蛋白全稱為C-X3-C基序趨化因子配體1，別名CXC3。這種獨(dú)特的趨化因子以跨膜形式存在于細(xì)胞表面，同時(shí)可被酶切釋放為可溶形式，兼具細(xì)胞黏附和趨化雙重功能。CX3CL1通過(guò)結(jié)合CX3CR1受體，在單核細(xì)胞、T細(xì)胞和神經(jīng)小膠質(zhì)細(xì)胞的遷移中起關(guān)鍵作用，尤其在神經(jīng)免疫交互中表現(xiàn)突出。
CX3CL1與阿爾茨海默病、帕金森病等神經(jīng)退行性疾病密切相關(guān)，腦內(nèi)小膠質(zhì)細(xì)胞通過(guò)CX3CL1-CX3CR1軸調(diào)控神經(jīng)炎癥進(jìn)程。在心血管領(lǐng)域，CX3CL1參與動(dòng)脈粥樣硬化斑塊形成，促進(jìn)單核細(xì)胞向血管壁浸潤(rùn)。針對(duì)該通路的藥物開(kāi)發(fā)已進(jìn)入臨床試驗(yàn)階段，例如E6011單抗通過(guò)阻斷CX3CL1-CX3CR1相互作用，在類風(fēng)濕性關(guān)節(jié)炎和狼瘡性腎炎治療中顯示出潛力。阿爾茨海默病動(dòng)物模型中，抑制該通路可減少β淀粉樣蛋白沉積，為神經(jīng)退行性疾病治療提供了新方向。
熱銷產(chǎn)品
Recombinant Human Fractalkine (CX3CL1), partial, Biotinylated (CSB-MP006235HU-B)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CX3CL1 Antibody (CSB-PA06087A0Rb)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA06087A0Rb at dilution of 1:100
Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA06087A0Rb at dilution of 1:100
Immunofluorescent analysis of Hela cells cells using CSB-PA06087A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
CX3CL1 Antibodies
CX3CL1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA06087A0Rb | CX3CL1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA006235GA01HU | CX3CL1 Antibody | Human | ELISA,WB |
| CSB-PA005564 | CX3CL1 Antibody | Human | WB, ELISA |
| CSB-PA092112 | CX3CL1 Antibody | Human,Mouse,Rat | ELISA,IHC |
CX3CL1 Proteins
CX3CL1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006235HU CSB-EP006235HU CSB-BP006235HU CSB-MP006235HU CSB-EP006235HU-B |
Recombinant Human Fractalkine (CX3CL1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP006235HU(F) | Recombinant Human Fractalkine (CX3CL1), partial | E.coli |
| CSB-AP000801HU | Recombinant Human Fractalkine protein (CX3CL1), partial (Active) | E.Coli |
| CSB-MP006235HU-B | Recombinant Human Fractalkine (CX3CL1), partial, Biotinylated | Mammalian cell |
CX3CL1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006235MO1 CSB-EP006235MO1 CSB-BP006235MO1 CSB-MP006235MO1 CSB-EP006235MO1-B |
Recombinant Mouse Fractalkine (Cx3cl1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP001211MO | Recombinant Mouse Fractalkine protein (Cx3cl1), partial (Active) | E.Coli |
| CSB-CF006235MO | Recombinant Mouse Fractalkine (Cx3cl1) | in vitro E.coli expression system |
CX3CL1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006235RA1 CSB-EP006235RA1 CSB-BP006235RA1 CSB-MP006235RA1 CSB-EP006235RA1-B |
Recombinant Rat Fractalkine (Cx3cl1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP001511RA | Recombinant Rat Fractalkine protein (Cx3cl1), partial (Active) | E.Coli |
| CSB-CF006235RA | Recombinant Rat Fractalkine (Cx3cl1) | in vitro E.coli expression system |
CX3CL1 ELISA Kit
CX3CL1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04558h | Human Fractalkine,FK ELISA Kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
CX3CL1 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04559m | Mouse Fractalkine,FK ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 31.25 pg/mL |
CX3CL1 ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04560r | Rat Fractalkine,FK ELISA Kit | serum, plasma | 0.078 ng/mL |
