CX3CR1
CX3CR1全稱為CX3C趨化因子受體1，也被稱為Fractalkine受體或G蛋白偶聯(lián)受體13。這種蛋白主要分布在單核細(xì)胞、小膠質(zhì)細(xì)胞和自然殺傷細(xì)胞表面，通過(guò)與其配體Fractalkine的相互作用，調(diào)控免疫細(xì)胞的遷移與黏附功能，尤其在炎癥反應(yīng)和免疫監(jiān)視中發(fā)揮重要作用。研究發(fā)現(xiàn)，CX3CR1介導(dǎo)的細(xì)胞間通訊與神經(jīng)退行性疾病密切相關(guān)，例如阿爾茨海默病患者腦內(nèi)小膠質(zhì)細(xì)胞的異常激活便與其功能失調(diào)存在關(guān)聯(lián)。此外，該受體在動(dòng)脈粥樣硬化斑塊形成過(guò)程中參與單核細(xì)胞的浸潤(rùn)，與心血管疾病的發(fā)展密切相關(guān)。
近年來(lái)，針對(duì)CX3CR1的藥物開發(fā)聚焦于炎癥性疾病治療領(lǐng)域。部分小分子抑制劑已在動(dòng)物模型中展現(xiàn)出抑制神經(jīng)炎癥和延緩動(dòng)脈斑塊進(jìn)展的效果。臨床前研究還發(fā)現(xiàn)，阻斷CX3CR1可能緩解類風(fēng)濕性關(guān)節(jié)炎的關(guān)節(jié)損傷。目前已有單克隆抗體類藥物進(jìn)入早期臨床試驗(yàn)階段，嘗試通過(guò)調(diào)控免疫細(xì)胞遷移來(lái)治療多發(fā)性硬化等自身免疫疾病。與此同時(shí)，該受體在腫瘤微環(huán)境中的雙重作用也引起關(guān)注，既有研究支持其促進(jìn)腫瘤免疫逃逸，也有證據(jù)表明可能增強(qiáng)抗腫瘤免疫應(yīng)答，這一矛盾特性為靶向治療帶來(lái)挑戰(zhàn)。
熱銷產(chǎn)品
CX3CR1 Antibody (CSB-PA006236LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA006236LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA006236LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human CX3C-chemokine receptor 1,CX3CR1 ELISA Kit (CSB-E09942h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E09942h
規(guī)格：96T/48T
靈敏度：7.8 pg/mL
檢測(cè)范圍：31.25 pg/mL-2000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
CX3CR1 Antibodies
CX3CR1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA006236GA01HU | CX3CR1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA004776 | CX3CR1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA007487 | CX3CR1 Antibody | Human | IHC, IF, ELISA |
| CSB-PA135132 | CX3CR1 Antibody | Human | ELISA,WB |
| CSB-PA080771 | CX3CR1 Antibody | Human | ELISA,WB |
| CSB-PA006236LA01HU | CX3CR1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA006236LB01HU | CX3CR1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA006236LC01HU | CX3CR1 Antibody, FITC conjugated | Human | |
| CSB-PA006236LD01HU | CX3CR1 Antibody, Biotin conjugated | Human | ELISA |
CX3CR1 Proteins
CX3CR1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006236HU1 CSB-EP006236HU1 CSB-BP006236HU1 CSB-MP006236HU1 CSB-EP006236HU1-B |
Recombinant Human CX3C chemokine receptor 1 (CX3CR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006236HU | Recombinant Human CX3C chemokine receptor 1 (CX3CR1) | in vitro E.coli expression system |
| CSB-MP006236HU | Recombinant Human CX3C chemokine receptor 1 (CX3CR1)-VLPs | Mammalian cell |
CX3CR1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006236BO1 CSB-EP006236BO1 CSB-BP006236BO1 CSB-MP006236BO1 CSB-EP006236BO1-B |
Recombinant Bovine CX3C chemokine receptor 1 (CX3CR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006236BO | Recombinant Bovine CX3C chemokine receptor 1 (CX3CR1) | in vitro E.coli expression system |
CX3CR1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006236RA1 CSB-EP006236RA1 CSB-BP006236RA1 CSB-MP006236RA1 CSB-EP006236RA1-B |
Recombinant Rat CX3C chemokine receptor 1 (Cx3cr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006236RA | Recombinant Rat CX3C chemokine receptor 1 (Cx3cr1) | in vitro E.coli expression system |
CX3CR1 Proteins for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP644447RB1 CSB-EP644447RB1 CSB-BP644447RB1 CSB-MP644447RB1 CSB-EP644447RB1-B |
Recombinant Rabbit CX3C chemokine receptor 1 (CX3CR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF644447RB | Recombinant Rabbit CX3C chemokine receptor 1 (CX3CR1) | in vitro E.coli expression system |
CX3CR1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP897445MO1 CSB-EP897445MO1 CSB-BP897445MO1 CSB-MP897445MO1 CSB-EP897445MO1-B |
Recombinant Mouse CX3C chemokine receptor 1 (Cx3cr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF897445MO | Recombinant Mouse CX3C chemokine receptor 1 (Cx3cr1) | in vitro E.coli expression system |
CX3CR1 ELISA Kit
CX3CR1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09942h | Human CX3C-chemokine receptor 1,CX3CR1 ELISA Kit | serum, plasma, tissue homogenates | 7.8 pg/mL |
CX3CR1 ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL006236RA | Rat CX3C chemokine receptor 1(CX3CR1) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 5.8 pg/mL |
