CXCR6
CXCR6，全稱C-X-C chemokine receptor type 6，常見別名包括BONZO、CD186、STRL33和TYMSTR。該蛋白屬于CXC趨化因子受體家族，主要表達(dá)在新激活的、新擴(kuò)增的且具有組織駐留特性的T細(xì)胞上。CXCR6與其配體CXCL16相互作用，介導(dǎo)了CXCR6+ T細(xì)胞的組織遷移和駐留，并進(jìn)一步激活這些細(xì)胞。在多種自身免疫性疾病中，如多發(fā)性硬化癥、白癜風(fēng)、克羅恩病、潰瘍性結(jié)腸炎和原發(fā)性膽汁性膽管炎等，CXCR6+ T細(xì)胞是關(guān)鍵致病細(xì)胞。近年來(lái)，針對(duì)CXCR6的藥物研發(fā)取得顯著進(jìn)展，例如邁威生物研發(fā)的抗CXCR6單抗2MW3311，已在多種自身免疫性疾病模型中展現(xiàn)出顯著的治療效果。此外，研究表明CXCR6在認(rèn)知障礙患者的腦脊液中表達(dá)升高，提示CXCL16-CXCR6信號(hào)通路可能是CD8+ T細(xì)胞進(jìn)入大腦的機(jī)制，為神經(jīng)退行性疾病的免疫治療提供了新的思路。
熱銷產(chǎn)品
Recombinant Human C-X-C chemokine receptor type 6 (CXCR6)-VLPs (CSB-MP006256HU)
驗(yàn)證數(shù)據(jù)
CSB-MP006256HU is detected by Mouse anti-6*His monoclonal antibody.
The purity of VLPs was greater than 90% as determined by SEC-HPLC
驗(yàn)證數(shù)據(jù)
Western Blot analysis of HeLa cells using Bonzo Polyclonal Antibody.
CXCR6 Antibodies
CXCR6 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA005634 | CXCR6 Antibody | Human | WB, ELISA |
| CSB-PA224134 | CXCR6 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA188638 | CXCR6 Antibody | Human,Mouse | ELISA,WB,IHC |
CXCR6 Proteins
CXCR6 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006256HU1 CSB-EP006256HU1 CSB-BP006256HU1 CSB-MP006256HU1 CSB-EP006256HU1-B |
Recombinant Human C-X-C chemokine receptor type 6 (CXCR6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006256HU | Recombinant Human C-X-C chemokine receptor type 6 (CXCR6) | in vitro E.coli expression system |
| CSB-MP006256HU | Recombinant Human C-X-C chemokine receptor type 6 (CXCR6)-VLPs | Mammalian cell |
CXCR6 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006256DSU1 CSB-EP006256DSU1 CSB-BP006256DSU1 CSB-MP006256DSU1 CSB-EP006256DSU1-B |
Recombinant Chlorocebus aethiops C-X-C chemokine receptor type 6 (CXCR6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006256DSU | Recombinant Chlorocebus aethiops C-X-C chemokine receptor type 6 (CXCR6) | in vitro E.coli expression system |
CXCR6 Proteins for Macaca nemestrina (Pig-tailed macaque)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006256MOX1 CSB-EP006256MOX1 CSB-BP006256MOX1 CSB-MP006256MOX1 CSB-EP006256MOX1-B |
Recombinant Macaca nemestrina C-X-C chemokine receptor type 6 (CXCR6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006256MOX | Recombinant Macaca nemestrina C-X-C chemokine receptor type 6 (CXCR6) | in vitro E.coli expression system |
CXCR6 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP861038MOV1 CSB-EP861038MOV1 CSB-BP861038MOV1 CSB-MP861038MOV1 CSB-EP861038MOV1-B |
Recombinant Macaca fascicularis C-X-C chemokine receptor type 6 (CXCR6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF861038MOV | Recombinant Macaca fascicularis C-X-C chemokine receptor type 6 (CXCR6) | in vitro E.coli expression system |
CXCR6 Proteins for Pan troglodytes (Chimpanzee)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP866150EQV1 CSB-EP866150EQV1 CSB-BP866150EQV1 CSB-MP866150EQV1 CSB-EP866150EQV1-B |
Recombinant Pan troglodytes C-X-C chemokine receptor type 6 (CXCR6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF866150EQV | Recombinant Pan troglodytes C-X-C chemokine receptor type 6 (CXCR6) | in vitro E.coli expression system |
CXCR6 Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP878786DRI1 CSB-EP878786DRI1 CSB-BP878786DRI1 CSB-MP878786DRI1 CSB-EP878786DRI1-B |
Recombinant Cercocebus atys C-X-C chemokine receptor type 6 (CXCR6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF878786DRI | Recombinant Cercocebus atys C-X-C chemokine receptor type 6 (CXCR6) | in vitro E.coli expression system |
CXCR6 Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP893172MOW1 CSB-EP893172MOW1 CSB-BP893172MOW1 CSB-MP893172MOW1 CSB-EP893172MOW1-B |
Recombinant Macaca mulatta C-X-C chemokine receptor type 6 (CXCR6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF893172MOW | Recombinant Macaca mulatta C-X-C chemokine receptor type 6 (CXCR6) | in vitro E.coli expression system |
