FOXO3

FOXO3，全稱為叉頭框轉(zhuǎn)錄因子3，是叉頭框O類轉(zhuǎn)錄因子家族的重要成員。該蛋白參與多種生物學(xué)過程，包括能量代謝、細(xì)胞凋亡、DNA修復(fù)和氧化應(yīng)激等。FOXO3蛋白在維持細(xì)胞穩(wěn)態(tài)和組織健康中發(fā)揮著關(guān)鍵作用。研究表明，F(xiàn)OXO3蛋白在皮膚健康中具有重要作用，其表達(dá)與黑素生成、傷口愈合、痤瘡和黑色素瘤等皮膚相關(guān)問題密切相關(guān)。此外，F(xiàn)OXO3蛋白還與AML（急性髓系白血病）的發(fā)生發(fā)展及耐藥性密切相關(guān)。研究發(fā)現(xiàn)，F(xiàn)OXO3蛋白的高表達(dá)與AML患者的不良預(yù)后相關(guān)，并且可能通過調(diào)節(jié)自噬參與AML蒽環(huán)類藥物耐藥的機(jī)制。基于這些發(fā)現(xiàn)，F(xiàn)OXO3蛋白有望成為AML治療中的潛在靶點(diǎn)。目前，針對FOXO3蛋白的藥物研發(fā)正在積極開展中，以期開發(fā)出更有效的AML治療藥物。

熱銷產(chǎn)品

Recombinant Human Forkhead box protein O3 (FOXO3), partial (CSB-EP008836HU1)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

FOXO3 Recombinant Monoclonal Antibody (CSB-RA008836A0HU)

驗(yàn)證數(shù)據(jù)

Western Blot
Positive WB detected in: 293 whole cell lysate, Jurkat whole cell lysate, SH-SY5Y whole cell lysate, U87 whole cell lysate
All lanes: FOXO3A antibody at 1.8μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 72, 49 KDa
Observed band size: 72-90 KDa

IHC image of CSB-RA008836A0HU diluted at 1:180 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-RA008836A0HU diluted at 1:180 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of PC3 cells with CSB-RA008836A0HU at 1:60, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).

Human forkhead box O3,FOXO3 ELISA Kit (CSB-E11177h)

驗(yàn)證數(shù)據(jù)

貨號：CSB-E11177h

規(guī)格：96T/48T

靈敏度：0.39 pg/mL

檢測范圍：1.56 pg/mL-100 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

FOXO3 Antibody

FOXO3 Protein

FOXO3 ELISA Kit

FOXO3 Antibodies

FOXO3 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA058993	FOXO3 (Ab-253) Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA030478	Phospho-FOXO3 (Ser253) Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA002574	FOXO3 Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA008324	Phospho-FOXO3 (S253) Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA008325	FOXO3 Antibody	Human,Mouse,Rat	IHC, ELISA
CSB-PA582057	FOXO3 Antibody	Human,Mouse	ELISA,IHC
CSB-PA572384	FOXO3 Antibody	Human,Mouse	ELISA,IHC
CSB-PA207434	FOXO3 Antibody	Human,Mouse,Rat	WB,ELISA
CSB-RA008836A253phHU	Phospho-FOXO3 (S253) Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC
CSB-RA008836A0HU	FOXO3 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IF

FOXO3 Proteins

FOXO3 Proteins for Xenopus laevis (African clawed frog)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP735391XBE CSB-EP735391XBE CSB-BP735391XBE CSB-MP735391XBE CSB-EP735391XBE-B	Recombinant Xenopus laevis Forkhead box protein O3 (foxo3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FOXO3 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP895304MO CSB-EP895304MO CSB-BP895304MO CSB-MP895304MO CSB-EP895304MO-B	Recombinant Mouse Forkhead box protein O3 (Foxo3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FOXO3 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-EP008836HU1	Recombinant Human Forkhead box protein O3 (FOXO3), partial	E.coli
CSB-YP008836HU1 CSB-BP008836HU1 CSB-MP008836HU1 CSB-EP008836HU1-B	Recombinant Human Forkhead box protein O3 (FOXO3), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli