FTH1
FTH1，即鐵蛋白重鏈1，別名FHC、FTH、FTHL6、HFE5、PIG15、PLIF等。它廣泛來(lái)源于動(dòng)物和植物細(xì)胞，是鐵蛋白的主要組成部分。FTH1能夠?qū)C(jī)體內(nèi)的鐵離子催化成Fe3+并儲(chǔ)存，以維持正常的鐵穩(wěn)態(tài)；具有亞鐵氧化酶活性，促進(jìn)鐵的氧化和細(xì)胞對(duì)鐵的攝??；還具備抗氧化應(yīng)激功能，能夠降解自由基，有效阻止由過(guò)量鐵引起的氧化損害。FTH1參與鐵代謝過(guò)程，包括鐵的吸收、轉(zhuǎn)運(yùn)和利用，同時(shí)還參與免疫應(yīng)答、細(xì)胞增殖等生理過(guò)程，并對(duì)細(xì)胞具有保護(hù)作用。FTH1還與多種疾病的發(fā)生相關(guān)，如鐵過(guò)載、神經(jīng)退行性疾病等，因此調(diào)控FTH1的表達(dá)可能是多種疾病潛在的治療靶點(diǎn)。
熱銷(xiāo)產(chǎn)品
Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active) (CSB-MP007479HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of Mammalian Cell host and target protein, the LC-MS/MS Analysis result of CSB-MP007479HU could indicate that this peptide derived from Mammalian Cell-expressed Homo sapiens (Human) EGFR.
Based on the SEQUEST from database of Mammalian Cell host and target protein, the LC-MS/MS Analysis result of CSB-MP007479HU could indicate that this peptide derived from Mammalian Cell-expressed Homo sapiens (Human) EGFR.
Measured by its binding ability in a functional ELISA. Immobilized EGFR at 1 μg/ml can bind Anti-EGFR recombinant antibody, the EC50 of human EGFR protein is 2.867-3.571 ng/ml.
Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.
Activity
Measured by its binding ability in a functional ELISA. Immobilized EGFR at 1 μg/ml can bind Cetuximab, the EC50 of human EGFR protein is 0.6919-1.047 ng/ml.
The purity of EGFR was greater than 95% as determined by SEC-HPLC
EGFR Recombinant Monoclonal Antibody (CSB-RA159341MA1HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-RA159341MA1HU diluted at 1:50 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
IHC image of CSB-RA159341MA1HU diluted at 1:50 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
Overlay Peak curve showing NIH/3T3 cells stained with CSB-RA159341MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-Rabbit IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
FTH1 Antibodies
FTH1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA02084A0Rb | FTH1 Antibody | Human | ELISA |
| CSB-PA02084B0Rb | FTH1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA02084C0Rb | FTH1 Antibody, FITC conjugated | Human | |
| CSB-PA02084D0Rb | FTH1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA02089A0Rb | FTH1 Antibody | Human | ELISA |
| CSB-PA02089B0Rb | FTH1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA02089D0Rb | FTH1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA008485 | FTH1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA358768 | FTH1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA247700 | FTH1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-RA574579A0HU | FTH1 Recombinant Monoclonal Antibody | Human, Mouse | ELISA, WB, IF, FC |
| CSB-RA009030MA1HU | FTH1 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, FC |
FTH1 Proteins
FTH1 Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP009030PI CSB-EP009030PI CSB-BP009030PI CSB-MP009030PI CSB-EP009030PI-B |
Recombinant Pig Ferritin heavy chain (FTH1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FTH1 Proteins for Ovis aries (Sheep)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP009030SH CSB-EP009030SH CSB-BP009030SH CSB-MP009030SH CSB-EP009030SH-B |
Recombinant Sheep Ferritin heavy chain (FTH1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FTH1 Proteins for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP009030RB CSB-EP009030RB CSB-BP009030RB CSB-MP009030RB CSB-EP009030RB-B |
Recombinant Rabbit Ferritin heavy chain (FTH1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FTH1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP009030HU CSB-BP009030HU CSB-MP009030HU CSB-EP009030HU-B |
Recombinant Human Ferritin heavy chain (FTH1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP009030HU1 | Recombinant Human Ferritin heavy chain (FTH1) | E.coli |
| CSB-EP009030HU(M) | Recombinant Human Ferritin heavy chain (FTH1) (C103A) | E.coli |
| CSB-EP009030HU(M1) | Recombinant Human Ferritin heavy chain (FTH1) (H106A) | E.coli |
| CSB-EP009030HU | Recombinant Human Ferritin heavy chain (FTH1) | E.coli |
FTH1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP009030MO CSB-BP009030MO CSB-MP009030MO CSB-EP009030MO-B |
Recombinant Mouse Ferritin heavy chain (Fth1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FTH1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP009030BO CSB-EP009030BO CSB-BP009030BO CSB-MP009030BO CSB-EP009030BO-B |
Recombinant Bovine Ferritin heavy chain (FTH1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FTH1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP009030RA CSB-EP009030RA CSB-BP009030RA CSB-MP009030RA CSB-EP009030RA-B |
Recombinant Rat Ferritin heavy chain (Fth1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FTH1 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP009030DXU CSB-EP009030DXU CSB-BP009030DXU CSB-MP009030DXU CSB-EP009030DXU-B |
Recombinant Cricetulus griseus Ferritin heavy chain (FTH1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FTH1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP327818SVG1 CSB-EP327818SVG1 CSB-BP327818SVG1 CSB-MP327818SVG1 CSB-EP327818SVG1-B |
Recombinant Saccharomyces cerevisiae Iron transporter FTH1 (FTH1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF327818SVG | Recombinant Saccharomyces cerevisiae Iron transporter FTH1 (FTH1) | in vitro E.coli expression system |
FTH1 Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP646663CA CSB-EP646663CA CSB-BP646663CA CSB-MP646663CA CSB-EP646663CA-B |
Recombinant Cat Ferritin heavy chain (FTH1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FTH1 Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP728971PYX CSB-EP728971PYX CSB-BP728971PYX CSB-MP728971PYX CSB-EP728971PYX-B |
Recombinant Pongo abelii Ferritin heavy chain (FTH1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FTH1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP842569DO CSB-EP842569DO CSB-BP842569DO CSB-MP842569DO CSB-EP842569DO-B |
Recombinant Dog Ferritin heavy chain (FTH1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FTH1 Proteins for Trichosurus vulpecula (Brush-tailed possum)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP895017TQG CSB-EP895017TQG CSB-BP895017TQG CSB-MP895017TQG CSB-EP895017TQG-B |
Recombinant Trichosurus vulpecula Ferritin heavy chain (FTH1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FTH1 ELISA Kit
FTH1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-E16932h | Human Ferritin, Heavy Polypeptide (FTH) ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 0.11 ng/mL |
FTH1 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-EL009030MO | Mouse Ferritin heavy chain(FTH1) ELISA kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
FTH1 ELISA Kit for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-EL009030PI | Pig Ferritin heavy chain(FTH1) ELISA kit | serum, plasma, tissue homogenates | 1.175 ng/ml |
