FYN
FYN全稱為酪氨酸蛋白激酶Fyn，屬于Src家族成員，在細(xì)胞信號(hào)傳導(dǎo)中發(fā)揮核心作用。FYN存在兩種異構(gòu)體，分別通過(guò)不同剪切方式產(chǎn)生p59-Fyn和p58-Fyn，在T細(xì)胞受體激活、神經(jīng)元發(fā)育等過(guò)程中參與調(diào)控。其異常活化與多種惡性腫瘤密切相關(guān)，F(xiàn)yn激酶在乳腺癌、前列腺癌中通過(guò)PI3K/AKT通路促進(jìn)腫瘤轉(zhuǎn)移，在膠質(zhì)母細(xì)胞瘤中與表皮生長(zhǎng)因子受體形成致癌復(fù)合物。阿爾茨海默病患者腦組織中發(fā)現(xiàn)Fyn與Tau蛋白異常互作，加速神經(jīng)纖維纏結(jié)形成，而帕金森病模型中也觀察到該激酶對(duì)α-突觸核蛋白聚集的促進(jìn)作用。針對(duì)Fyn的藥物開發(fā)聚焦于激酶抑制劑領(lǐng)域，達(dá)沙替尼等廣譜Src抑制劑已進(jìn)入臨床研究，新型選擇性抑制劑如AZD0424在臨床前實(shí)驗(yàn)中顯示出對(duì)三陰性乳腺癌的特異性抑制作用。近期研究還發(fā)現(xiàn)Fyn在免疫檢查點(diǎn)調(diào)控中的作用，其與PD-1受體的相互作用為腫瘤免疫治療提供了新靶點(diǎn)。
熱銷產(chǎn)品
FYN Recombinant Monoclonal Antibody (CSB-RA699767A0HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-RA699767A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
IHC image of CSB-RA699767A0HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
FYN Antibodies
FYN for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA112548 | Phospho-FYN (Tyr530) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA914183 | FYN (Ab-530) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA002595 | FYN Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA008519 | Phospho-FYN (Y530) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA008520 | FYN Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA143385 | FYN Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA225018 | FYN Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA009101LA01HU | FYN Antibody | Human | ELISA, IHC, IF |
| CSB-RA699767A0HU | FYN Recombinant Monoclonal Antibody | Human | ELISA, IHC |
FYN Proteins
FYN Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP009101MO CSB-EP009101MO CSB-BP009101MO CSB-MP009101MO CSB-EP009101MO-B |
Recombinant Mouse Tyrosine-protein kinase Fyn (Fyn) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FYN Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP009101HU CSB-EP009101HU CSB-BP009101HU CSB-MP009101HU CSB-EP009101HU-B |
Recombinant Human Tyrosine-protein kinase Fyn (FYN) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FYN Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP009101BO CSB-EP009101BO CSB-BP009101BO CSB-MP009101BO CSB-EP009101BO-B |
Recombinant Bovine Tyrosine-protein kinase Fyn (FYN), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FYN Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP009101PI CSB-EP009101PI CSB-BP009101PI CSB-MP009101PI CSB-EP009101PI-B |
Recombinant Pig Tyrosine-protein kinase Fyn (FYN), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FYN Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP009101XBE CSB-EP009101XBE CSB-BP009101XBE CSB-MP009101XBE CSB-EP009101XBE-B |
Recombinant Xenopus laevis Tyrosine-protein kinase Fyn (fyn), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FYN Proteins for Xiphophorus helleri (Green swordtail)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP009101XBJ CSB-EP009101XBJ CSB-BP009101XBJ CSB-MP009101XBJ CSB-EP009101XBJ-B |
Recombinant Xiphophorus helleri Tyrosine-protein kinase Fyn (fyn), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FYN Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP723478RA CSB-EP723478RA CSB-BP723478RA CSB-MP723478RA CSB-EP723478RA-B |
Recombinant Rat Tyrosine-protein kinase Fyn (Fyn) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
