GPC1
GPC1，即磷脂球蛋白聚糖1（glypican1），別名Glypican-1、epididymissecretoryspermbindingprotein等。它是一種細(xì)胞表面硫酸乙酰肝素蛋白聚糖，由膜相關(guān)蛋白核心組成，該核心被可變數(shù)量的硫酸乙酰肝素鏈取代。GPC1通過(guò)糖基磷脂酰肌醇鍵固定在細(xì)胞質(zhì)膜上，屬于glypican相關(guān)的完整膜蛋白多糖家族（GRIPS）。其作用機(jī)制涉及調(diào)節(jié)多種信號(hào)通路，包括FGF、VEGF-A、TGF-β、Wnt、Hh和BMP，通過(guò)與通路配體和受體的特異性相互作用，影響信號(hào)通路的激活或抑制。GPC1在控制細(xì)胞分裂和生長(zhǎng)調(diào)節(jié)中發(fā)揮作用，參與發(fā)育過(guò)程，并在多種癌癥類型中表達(dá)明顯升高，包括胰腺癌、乳腺癌等，是癌癥檢測(cè)和治療的潛在生物標(biāo)志物。
熱銷產(chǎn)品
Recombinant Human Glypican-1 (GPC1), partial (CSB-EP009703HU1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
GPC1 Antibody (CSB-PA009703LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA009703LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA009703LA01HU at dilution of 1:100
Immunofluorescent analysis of MCF-7 cells using CSB-PA009703LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
GPC1 Antibodies
GPC1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA009703GA01HU | GPC1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA009703LA01HU | GPC1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA009703LB01HU | GPC1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA009703LC01HU | GPC1 Antibody, FITC conjugated | Human | |
| CSB-PA009703LD01HU | GPC1 Antibody, Biotin conjugated | Human | ELISA |
GPC1 Proteins
GPC1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP009703HU CSB-EP009703HU CSB-BP009703HU CSB-MP009703HU CSB-EP009703HU-B |
Recombinant Human Glypican-1 (GPC1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP009703HU1 | Recombinant Human Glypican-1 (GPC1), partial | E.coli |
GPC1 ELISA Kit
GPC1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL009703HU | Human glypican 1 (GPC1) ELISA kit | serum, plasma, tissue homogenates. | 0.039 ng/ml. |
