GPC3
GPC3是一種糖蛋白，具有特定的蛋白質(zhì)結(jié)構(gòu)，其中包括一個(gè)胞外糖基化的部分和一個(gè)胞漿部分?？梢耘c多種生長因子、信號(hào)分子和受體相互作用，從而影響細(xì)胞信號(hào)傳導(dǎo)通路。它可以促進(jìn)或抑制特定信號(hào)通路的激活，因此對(duì)于細(xì)胞生長、增殖和分化等過程具有調(diào)節(jié)作用。在胚胎發(fā)育中，GPC3對(duì)于正常器官和組織的形成至關(guān)重要。它在特定發(fā)育階段參與胚胎體軸的建立、四肢發(fā)育和器官的分化。 GPC3異常表達(dá)會(huì)影響疾病的發(fā)生發(fā)展，研究GCP3的功能和調(diào)節(jié)機(jī)制對(duì)于理解疾病的發(fā)病機(jī)制和開發(fā)相關(guān)治療方法具有重要意義。
更多相關(guān)閱讀：靶向GPC3在肝癌中初顯成效，未來聯(lián)合治療潛力更大
熱銷產(chǎn)品
● Recombinant Human Glypican-3(GPC3)(G537R),partial (Active) CSB-MP009705HU(M)
驗(yàn)證數(shù)據(jù)
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(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Activity: Measured by its binding ability in a functional ELISA. Immobilized human GPC3 (G537R) at 5 μg/ml can bind Anti-GPC3 recombinant antibody, the EC50 is 4.739-7.092 ng/ml.
● GPC3 Recombinant Monoclonal Antibody CSB-RA009705A0HU
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: 293 whole cell lysate, K562 whole cell lysate All lanes: GPC3 antibody at 0.9μg/ml. Secondary, Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 66, 60, 69 KDa Observed band size: 66 KDa
Immunofluorescence staining of HepG2 cells with CSB-RA009705A0HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
● CT26/Human GPC3 Stable Cell Line CSB-SC009705HU2
驗(yàn)證數(shù)據(jù)
Untransfected CT26 cells (green line) and transfected Human GPC3 CT26 Stable cells (red line) were stained with anti-GPC3 antibody(CSB-RA009705A1HU) (2µg/1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
GPC3 Antibodies
GPC3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA009705GA01HU | GPC3 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA005135 | GPC3 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-RA009705A0HU | GPC3 Recombinant Monoclonal Antibody | Human | ELISA, WB, IF |
| CSB-PA12749A0Rb | GPC3 Antibody | Human | ELISA, IF |
| CSB-PA12749B0Rb | GPC3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA12749C0Rb | GPC3 Antibody, FITC conjugated | Human | |
| CSB-PA12749D0Rb | GPC3 Antibody, Biotin conjugated | Human | ELISA |
| CSB-MA009705A0m | GPC3 Monoclonal Antibody | Human | ELISA, WB, FC |
| CSB-RA009705A1HU | GPC3 Recombinant Monoclonal Antibody | Human | ELISA |
| CSB-RA009705MA1HU | GPC3 Recombinant Monoclonal Antibody | Human | ELISA, FC |
GPC3 Proteins
GPC3 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP009705RA | Recombinant Rat Glypican-3 (Gpc3), partial | Yeast |
| CSB-EP009705RA CSB-BP009705RA CSB-MP009705RA CSB-EP009705RA-B |
Recombinant Rat Glypican-3 (Gpc3), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GPC3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP009705HU CSB-EP009705HU CSB-BP009705HU CSB-EP009705HU-B |
Recombinant Human Glypican-3 (GPC3), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-AP005371HU | Recombinant Human Glypican-3 (GPC3), partial (Active) | Mammalian cell |
| CSB-MP009705HU(M) | Recombinant Human Glypican-3 (GPC3) (G537R), partial (Active) | Mammalian cell |
| CSB-MP009705HU(M2) | Recombinant Human Glypican-3 (GPC3)(S359F), partial (Active) | Mammalian cell |
GPC3 Proteins for Pan troglodytes (Chimpanzee)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP009705EQV CSB-EP009705EQV CSB-BP009705EQV CSB-EP009705EQV-B |
Recombinant Pan troglodytes Glypican-3 (GPC3), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP009705EQV | Recombinant Pan troglodytes Glypican-3 (GPC3) | Mammalian cell |
GPC3 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP804039MO CSB-EP804039MO CSB-BP804039MO CSB-MP804039MO CSB-EP804039MO-B |
Recombinant Mouse Glypican-3 (Gpc3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GPC3 ELISA Kit
GPC3 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E11333h | Human Glypican-3,GPC-3 ELISA Kit | serum, urine, cell culture supernates | 0.156 ng/mL |
GPC3 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E15877m | Mouse Glypican-3(GPC-3)ELISA Kit | serum, plasma, cell culture supernates | 0.78 ng/mL |
GPC3 ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL009705RA | Rat Glypican-3(GPC3) ELISA kit | serum, plasma, tissue homogenates | 3.9 pg/mL |
