LEPR
瘦素受體（Leptin Receptor，簡(jiǎn)稱LEPR）是一種重要的細(xì)胞表面受體，屬于細(xì)胞因子受體超家族。該受體主要由瘦素（Leptin）激活，瘦素是一種由脂肪組織分泌的激素，主要功能是調(diào)節(jié)機(jī)體的能量平衡和食欲。瘦素受體在腦部和外周組織中均有表達(dá)，其中在腦部的下丘腦中表達(dá)最為豐富，下丘腦是調(diào)節(jié)食欲和能量消耗的關(guān)鍵中樞。
瘦素受體在瘦素信號(hào)通路中起著核心作用。當(dāng)瘦素與瘦素受體結(jié)合后，會(huì)激活受體二聚化，進(jìn)而觸發(fā)一系列信號(hào)傳導(dǎo)過(guò)程，最終導(dǎo)致下丘腦食欲中樞的抑制，減少食物攝入，增加能量消耗，從而幫助機(jī)體減輕體重。瘦素受體還參與調(diào)節(jié)多種生理過(guò)程，如脂肪代謝、血糖水平、免疫功能等。瘦素受體缺陷會(huì)導(dǎo)致機(jī)體無(wú)法正常響應(yīng)瘦素的信號(hào)，進(jìn)而引發(fā)肥胖癥。此外，瘦素受體缺陷還與一些其他疾病相關(guān)，如2型糖尿病、心血管疾病、神經(jīng)退行性疾病等。
針對(duì)瘦素受體及其信號(hào)通路，研究人員已經(jīng)開(kāi)發(fā)出一些藥物用于治療肥胖癥和其他相關(guān)疾病。例如，Setmelanotide是一種瘦素受體激動(dòng)劑，可以用于治療因瘦素受體基因缺陷導(dǎo)致的肥胖癥。此外，還有許多其他藥物正在研發(fā)中，以期提高瘦素受體的敏感性，增強(qiáng)瘦素信號(hào)通路的效果，從而更好地治療肥胖癥和其他相關(guān)疾病。
熱銷產(chǎn)品
LEPR Antibody (CSB-PA06809A0Rb)
驗(yàn)證數(shù)據(jù)
Immunofluorescent analysis of HepG2 cells using CSB-PA06809A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human Leptin receptor,LR/Ob-R ELISA KIT (CSB-E04647h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E04647h
規(guī)格：96T/48T
靈敏度：0.78 pg/mL
檢測(cè)范圍：3.12 pg/mL-200 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
LEPR Antibodies
LEPR for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA000752 | Phospho-LEPR (Y1141) Antibody | Human,Mouse | WB, ELISA |
| CSB-PA003500 | LEPR Antibody | Human | WB, IHC, ELISA |
| CSB-PA005308 | LEPR Antibody | Human | WB, ELISA |
| CSB-PA009807 | LEPR Antibody | Human,Mouse,Monkey | WB, IHC, ELISA |
| CSB-PA914116 | LEPR Antibody | Human | ELISA,WB,IHC |
| CSB-PA145488 | LEPR Antibody | Human | ELISA,IHC |
| CSB-PA06809A0Rb | LEPR Antibody | Human | ELISA, IF |
| CSB-PA06809D0Rb | LEPR Antibody, Biotin conjugated | Human | ELISA |
LEPR Proteins
LEPR Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP012871HU CSB-EP012871HU CSB-BP012871HU CSB-MP012871HU CSB-EP012871HU-B |
Recombinant Human Leptin receptor (LEPR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LEPR Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP012871MO CSB-EP012871MO CSB-BP012871MO CSB-MP012871MO CSB-EP012871MO-B |
Recombinant Mouse Leptin receptor (Lepr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LEPR Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP012871PI CSB-EP012871PI CSB-BP012871PI CSB-MP012871PI CSB-EP012871PI-B |
Recombinant Pig Leptin receptor (LEPR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LEPR Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP012871RA CSB-EP012871RA CSB-BP012871RA CSB-MP012871RA CSB-EP012871RA-B |
Recombinant Rat Leptin receptor (Lepr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LEPR Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP012871MOW CSB-EP012871MOW CSB-BP012871MOW CSB-MP012871MOW CSB-EP012871MOW-B |
Recombinant Macaca mulatta Leptin receptor (LEPR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LEPR ELISA Kit
LEPR ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04647h | Human Leptin receptor,LR/Ob-R ELISA KIT | serum, plasma, tissue homogenates | 0.78 pg/mL |
LEPR ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04648m | Mouse Leptin receptor,LR/Ob-R ELISA KIT | serum, plasma, tissue homogenates | 0.039 ng/ml |
