LY6E
LY6E蛋白全稱為淋巴細(xì)胞抗原6復(fù)合物E亞型，屬于GPI錨定膜蛋白家族，也被稱作SCA2或RIG-E。LY6E在細(xì)胞膜表面廣泛表達(dá)，尤其在免疫細(xì)胞和上皮細(xì)胞中活性較高，早期研究發(fā)現(xiàn)其參與細(xì)胞黏附與信號(hào)識(shí)別，近年研究揭示其具有雙重生物學(xué)特性：一方面可增強(qiáng)宿主對(duì)流感病毒、登革熱病毒等的抵抗能力，另一方面卻通過(guò)促進(jìn)膜融合機(jī)制協(xié)助新冠病毒入侵細(xì)胞。在腫瘤微環(huán)境中，LY6E的異常高表達(dá)與乳腺癌、肝癌等惡性腫瘤的轉(zhuǎn)移密切相關(guān)，可能通過(guò)調(diào)控表皮生長(zhǎng)因子受體通路加速癌細(xì)胞侵襲。針對(duì)該靶點(diǎn)的藥物開發(fā)尚處探索階段，2021年有研究團(tuán)隊(duì)報(bào)道了特異性單克隆抗體在小鼠模型中展現(xiàn)出抑制新冠感染的效果，而針對(duì)腫瘤治療的RNA干擾技術(shù)正在臨床前評(píng)估中。
熱銷產(chǎn)品
Recombinant Mouse Lymphocyte antigen 6E (Ly6e) (CSB-EP717533MO)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
LY6E Antibodies
LY6E for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA009885 | LY6E Antibody | Human | IF, ELISA |
| CSB-PA619076LA01HU | LY6E Antibody | Human | ELISA, IHC, IF |
| CSB-RA619076MA1HU | LY6E Recombinant Monoclonal Antibody | Human | ELISA, IF |
LY6E for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA717533LA01MO | Ly6e Antibody | Mouse, Human | ELISA, WB |
| CSB-PA717533LD01MO | Ly6e Antibody, Biotin conjugated | Mouse | ELISA |
| CSB-PA717533LC01MO | Ly6e Antibody, FITC conjugated | Mouse | |
| CSB-PA717533LB01MO | Ly6e Antibody, HRP conjugated | Mouse | ELISA |
LY6E Proteins
LY6E Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP619076HU CSB-BP619076HU CSB-EP619076HU-B |
Recombinant Human Lymphocyte antigen 6E (LY6E) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP619076HU | Recombinant Human Lymphocyte antigen 6E (LY6E) | E.coli |
| CSB-EP619076HUc7 | Recombinant Human Lymphocyte antigen 6E (LY6E) | E.coli |
| CSB-MP619076HU | Recombinant Human Lymphocyte antigen 6E (LY6E) (Active) | Mammalian cell |
LY6E Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP717533MO | Recombinant Mouse Lymphocyte antigen 6E (Ly6e) | Yeast |
| CSB-EP717533MO | Recombinant Mouse Lymphocyte antigen 6E (Ly6e) | E.coli |
| CSB-BP717533MO CSB-EP717533MO-B |
Recombinant Mouse Lymphocyte antigen 6E (Ly6e) | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP717533MOb1 | Recombinant Mouse Lymphocyte antigen 6E (Ly6e) | E.coli |
| CSB-EP717533MOa0 | Recombinant Mouse Lymphocyte antigen 6E (Ly6e) | E.coli |
LY6E Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP838571CH CSB-EP838571CH CSB-BP838571CH CSB-MP838571CH CSB-EP838571CH-B |
Recombinant Chicken Lymphocyte antigen 6E (LY6E), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
