MAP3K1
MAP3K1，即有絲分裂原活化蛋白激酶激酶1，別名MEKK1、MEKK、MEKK 1、SRXY6。MAP3K1在多種細(xì)胞信號(hào)傳導(dǎo)通路中發(fā)揮作用，特別是在MAPK信號(hào)傳導(dǎo)通路中。MAP3K1能激活下游的MAP2Ks和MAPKs，通過(guò)一系列的磷酸化步驟傳遞信號(hào)，從而調(diào)節(jié)細(xì)胞凋亡、生存、遷移和分化等多重作用。MAP3K1還參與泛素-蛋白酶系統(tǒng)，具有E3泛素蛋白連接酶活性，能夠促進(jìn)特定蛋白質(zhì)的泛素化和降解。MAP3K1的功能異常與多種癌癥的發(fā)生發(fā)展相關(guān)，包括乳腺癌和卵巢癌，是控制癌癥的潛在靶點(diǎn)。
熱銷產(chǎn)品
Phospho-MAP3K1 (Thr1402) Antibody (CSB-PA177236)
驗(yàn)證數(shù)據(jù)
Western blot analysis of extracts from JK cells (Lane 2), using MAP3K1 (Phospho-Thr1400) Antibody. The lane on the left is treated with antigen-specific peptide.
Immunohistochemical analysis of paraffin-embedded human brain tissue using MAP3K1 (Phospho-Thr1400) antibody (left)or the same antibody preincubated with blocking peptide (right).
MAP3K1 Antibodies
MAP3K1 for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA15289A0Rb | Map3k1 Antibody | Mouse | ELISA |
| CSB-PA15289C0Rb | Map3k1 Antibody, FITC conjugated | Mouse |
MAP3K1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA177236 | Phospho-MAP3K1 (Thr1402) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA010176 | Phospho-MAP3K1 (T1402) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA010177 | MAP3K1 Antibody | Human,Mouse,Rat | WB, IF, ELISA |
| CSB-PA442614 | MAP3K1 Antibody | Human,Mouse,Rat | WB,ELISA |
MAP3K1 Proteins
MAP3K1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP013417MO CSB-BP013417MO CSB-MP013417MO CSB-EP013417MO-B |
Recombinant Mouse Mitogen-activated protein kinase kinase kinase 1 (Map3k1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP013417MO | Recombinant Mouse Mitogen-activated protein kinase kinase kinase 1 (Map3k1), partial | E.coli |
MAP3K1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP013417RA CSB-EP013417RA CSB-BP013417RA CSB-MP013417RA CSB-EP013417RA-B |
Recombinant Rat Mitogen-activated protein kinase kinase kinase 1 (Map3k1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MAP3K1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP013417HU CSB-EP013417HU CSB-BP013417HU CSB-MP013417HU CSB-EP013417HU-B |
Recombinant Human Mitogen-activated protein kinase kinase kinase 1 (MAP3K1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
