PPARA
PPARA，即過(guò)氧化物酶體增殖物激活受體α，別名包括PPARα、NR1C1。PPARA是一種核受體，屬于PPAR家族成員之一，由人體細(xì)胞自身的基因編碼。PPARA在肝臟、心臟、骨骼肌、腎臟和棕色脂肪組織等多種組織中表達(dá)。其作用機(jī)制主要是通過(guò)與特定的配體結(jié)合，如脂肪酸和其衍生物，激活受體，形成異源二聚體與DNA上的PPAR響應(yīng)元件（PPREs）結(jié)合，調(diào)控下游基因的表達(dá)，從而參與脂質(zhì)代謝、能量平衡和細(xì)胞增殖等過(guò)程。PPARA在生物學(xué)上的意義非常廣泛，它在調(diào)節(jié)脂肪酸氧化、膽固醇代謝、炎癥反應(yīng)、細(xì)胞分化和腫瘤發(fā)生等方面發(fā)揮關(guān)鍵作用。PPARA的激活可以促進(jìn)線粒體脂肪酸氧化，提高能量代謝效率，降低血漿中的膽固醇和甘油三酯水平，對(duì)抗動(dòng)脈粥樣硬化。此外，PPARA還參與調(diào)節(jié)肝臟的解毒功能，影響藥物和毒物的代謝。PPARA的激動(dòng)劑，如纖維酸類藥物，被廣泛用于治療高脂血癥和相關(guān)心血管疾病。因此，PPARA是代謝性疾病和心血管疾病研究和治療中的一個(gè)重要靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human Peroxisome proliferator-activated receptor alpha (PPARA) (CSB-BP018421HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of Baculovirus host and target protein, the LC-MS/MS Analysis result of CSB-BP018421HU could indicate that this peptide derived from Baculovirus-expressed Homo sapiens (Human) PPARA.
Based on the SEQUEST from database of Baculovirus host and target protein, the LC-MS/MS Analysis result of CSB-BP018421HU could indicate that this peptide derived from Baculovirus-expressed Homo sapiens (Human) PPARA.
驗(yàn)證數(shù)據(jù)
Western Blot analysis of 3T3 cells using PPAR-α Polyclonal Antibody
Human peroxisome proliferators activator receptors alpha,PPAR-α ELISA Kit (CSB-E09754h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E09754h
規(guī)格：96T/48T
靈敏度：19.5 pg/mL
檢測(cè)范圍：78 pg/mL-5000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
PPARA Antibodies
PPARA for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA018421GA01HU | PPARA Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA030137 | PPARA Antibody | Human,Mouse,Rat | WB, IF, ELISA |
| CSB-PA945095 | PPARA Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA112569 | PPARA Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA018421LA01HU | PPARA Antibody | Human | ELISA, WB |
| CSB-PA018421LB01HU | PPARA Antibody,HRP conjugated | Human | ELISA |
| CSB-PA018421LC01HU | PPARA Antibody，F(xiàn)ITC conjugated | Human | |
| CSB-PA018421LD01HU | PPARA Antibody，Biotin conjugated | Human | ELISA |
PPARA Proteins
PPARA Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP018421MO CSB-EP018421MO CSB-BP018421MO CSB-MP018421MO CSB-EP018421MO-B |
Recombinant Mouse Peroxisome proliferator-activated receptor alpha (Ppara) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPARA Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP018421RA CSB-EP018421RA CSB-BP018421RA CSB-MP018421RA CSB-EP018421RA-B |
Recombinant Rat Peroxisome proliferator-activated receptor alpha (Ppara) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPARA Proteins for Cavia porcellus (Guinea pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP018421GU CSB-EP018421GU CSB-BP018421GU CSB-MP018421GU CSB-EP018421GU-B |
Recombinant Guinea pig Peroxisome proliferator-activated receptor alpha (PPARA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPARA Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP018421XBE CSB-EP018421XBE CSB-BP018421XBE CSB-MP018421XBE CSB-EP018421XBE-B |
Recombinant Xenopus laevis Peroxisome proliferator-activated receptor alpha (ppara) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPARA Proteins for Phascolarctos cinereus (Koala)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP018421EUM CSB-EP018421EUM CSB-BP018421EUM CSB-MP018421EUM CSB-EP018421EUM-B |
Recombinant Phascolarctos cinereus Peroxisome proliferator-activated receptor alpha (PPARA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPARA Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP018421DO CSB-EP018421DO CSB-BP018421DO CSB-MP018421DO CSB-EP018421DO-B |
Recombinant Dog Peroxisome proliferator-activated receptor alpha (PPARA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPARA Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-BP018421HU | Recombinant Human Peroxisome proliferator-activated receptor alpha (PPARA) | Baculovirus |
PPARA ELISA Kit
PPARA ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09754h | Human peroxisome proliferators activator receptors alpha,PPAR-α ELISA Kit | serum, plasma, tissue homogenates | 19.5 pg/mL |
PPARA ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09755r | Rat peroxisome proliferators activator receptors alpha,PPAR-α ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 0.078 ng/mL |
