PPIA
PPIA，全稱為肽基丙氨酸異構(gòu)酶A，是一種廣泛存在于細(xì)胞中的酶類蛋白，常見別名包括p31、CYCA、CyP-A和p1B15。該蛋白具有環(huán)孢素A結(jié)合活性，參與磷酸蛋白磷酸酶活性的負(fù)調(diào)控，主要位于細(xì)胞質(zhì)、細(xì)胞外區(qū)域和細(xì)胞核中，并預(yù)測(cè)是含蛋白質(zhì)復(fù)合物的一部分。PPIA蛋白在細(xì)胞質(zhì)和細(xì)胞內(nèi)膜界限明確的細(xì)胞器中活躍，被用于研究癲癇等神經(jīng)系統(tǒng)疾病。研究表明，PPIA蛋白的人類同源物與膽管癌和人類免疫缺陷病毒感染疾病有關(guān)。
在藥物研發(fā)方面，PPIA蛋白已成為一個(gè)重要的靶點(diǎn)。例如，研究發(fā)現(xiàn)PPIA蛋白與NRF2蛋白的相互作用對(duì)肺癌的發(fā)生發(fā)展有重要影響，通過抑制PPIA/NRF2相互作用，可以降低NRF2蛋白水平，從而抑制肺癌細(xì)胞的增殖。此外，PPIA蛋白還與HIV蛋白相互作用，這為開發(fā)抗HIV藥物提供了新的思路。目前，針對(duì)PPIA蛋白的藥物研發(fā)正在積極進(jìn)行中，有望為相關(guān)疾病的治療提供新的選擇。
熱銷產(chǎn)品
Recombinant Human Peptidyl-prolyl cis-trans isomerase A (PPIA) (CSB-EP351810HU1e1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PPIA Recombinant Monoclonal Antibody (CSB-RA917671A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: Raji whole cell lysate, HepG2 whole cell lysate
All lanes: Cyclophilin A antibody at 1:1500
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 19, 12 kDa
Observed band size: 19 kDa
PPIA Antibodies
PPIA for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA018446GA01HU | PPIA Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA07814D0Rb | PPIA Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA07814B0Rb | PPIA Antibody, HRP conjugated | Human | ELISA |
| CSB-PA07814C0Rb | PPIA Antibody, FITC conjugated | Human | |
| CSB-PA07814A0Rb | PPIA Antibody | Human, Mouse | ELISA, WB |
| CSB-PA005117 | PPIA Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA731155 | PPIA Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA014187 | PPIA Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-RA917671A0HU | PPIA Recombinant Monoclonal Antibody | Human | ELISA, WB |
PPIA Proteins
PPIA Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018446MO CSB-EP018446MO CSB-BP018446MO CSB-MP018446MO CSB-EP018446MO-B |
Recombinant Mouse Peptidyl-prolyl cis-trans isomerase A (Ppia) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-EP351810HU1 | Recombinant Human Peptidyl-prolyl cis-trans isomerase A (PPIA) | E.coli |
| CSB-YP351810HU CSB-BP351810HU CSB-MP351810HU CSB-EP351810HU-B |
Recombinant Human Peptidyl-prolyl cis-trans isomerase A (PPIA) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP351810HU | Recombinant Human Peptidyl-prolyl cis-trans isomerase A (PPIA) | E.coli |
| CSB-EP351810HU1e1 | Recombinant Human Peptidyl-prolyl cis-trans isomerase A (PPIA) | E.coli |
PPIA Proteins for Streptomyces anulatus (Streptomyces chrysomallus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP312330SNK CSB-EP312330SNK CSB-BP312330SNK CSB-MP312330SNK CSB-EP312330SNK-B |
Recombinant Streptomyces anulatus Peptidyl-prolyl cis-trans isomerase A (ppiA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP318604DXU CSB-EP318604DXU CSB-BP318604DXU CSB-MP318604DXU CSB-EP318604DXU-B |
Recombinant Cricetulus griseus Peptidyl-prolyl cis-trans isomerase A (PPIA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP320617RA CSB-EP320617RA CSB-BP320617RA CSB-MP320617RA CSB-EP320617RA-B |
Recombinant Rat Peptidyl-prolyl cis-trans isomerase A (Ppia) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP322687SXB CSB-EP322687SXB CSB-BP322687SXB CSB-MP322687SXB CSB-EP322687SXB-B |
Recombinant Salmonella typhimurium Peptidyl-prolyl cis-trans isomerase A (ppiA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP351207DSU CSB-EP351207DSU CSB-BP351207DSU CSB-MP351207DSU CSB-EP351207DSU-B |
Recombinant Chlorocebus aethiops Peptidyl-prolyl cis-trans isomerase A (PPIA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Papio anubis (Olive baboon)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP351208ERI CSB-EP351208ERI CSB-BP351208ERI CSB-MP351208ERI CSB-EP351208ERI-B |
Recombinant Papio anubis Peptidyl-prolyl cis-trans isomerase A (PPIA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP351809BO CSB-EP351809BO CSB-BP351809BO CSB-MP351809BO CSB-EP351809BO-B |
Recombinant Bovine Peptidyl-prolyl cis-trans isomerase A (PPIA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP352383PI CSB-EP352383PI CSB-BP352383PI CSB-MP352383PI CSB-EP352383PI-B |
Recombinant Pig Peptidyl-prolyl cis-trans isomerase A (PPIA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP352384MOW CSB-EP352384MOW CSB-BP352384MOW CSB-MP352384MOW CSB-EP352384MOW-B |
Recombinant Macaca mulatta Peptidyl-prolyl cis-trans isomerase A (PPIA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Mycobacterium bovis
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP354595MVH CSB-EP354595MVH CSB-BP354595MVH CSB-MP354595MVH CSB-EP354595MVH-B |
Recombinant Probable peptidyl-prolyl cis-trans isomerase A (ppiA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Escherichia coli (strain K12)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP360283ENV CSB-EP360283ENV CSB-BP360283ENV CSB-MP360283ENV CSB-EP360283ENV-B |
Recombinant Escherichia coli Peptidyl-prolyl cis-trans isomerase A (ppiA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Escherichia coli O157:H7
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP360284EOD CSB-BP360284EOD CSB-MP360284EOD CSB-EP360284EOD-B |
Recombinant Escherichia coli Peptidyl-prolyl cis-trans isomerase A (ppiA) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP360284EOD | Recombinant Escherichia coli Peptidyl-prolyl cis-trans isomerase A (ppiA) | E.coli |
PPIA Proteins for Escherichia coli O6
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP365318EGX CSB-BP365318EGX CSB-MP365318EGX CSB-EP365318EGX-B |
Recombinant Escherichia coli O6:H1 Peptidyl-prolyl cis-trans isomerase A (ppiA) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP515898HUV CSB-EP515898HUV CSB-BP515898HUV CSB-MP515898HUV CSB-EP515898HUV-B |
Recombinant Helicobacter pylori Peptidyl-prolyl cis-trans isomerase (ppiA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Gorilla gorilla gorilla (Lowland gorilla)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP604535GGZ CSB-EP604535GGZ CSB-BP604535GGZ CSB-MP604535GGZ CSB-EP604535GGZ-B |
Recombinant Gorilla gorilla gorilla Peptidyl-prolyl cis-trans isomerase A (PPIA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Hylobates syndactylus (Siamang) (Symphalangus syndactylus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP605918HXY CSB-EP605918HXY CSB-BP605918HXY CSB-MP605918HXY CSB-EP605918HXY-B |
Recombinant Hylobates syndactylus Peptidyl-prolyl cis-trans isomerase A (PPIA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Hylobates lar (Common gibbon)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP607325HXW CSB-EP607325HXW CSB-BP607325HXW CSB-MP607325HXW CSB-EP607325HXW-B |
Recombinant Hylobates lar Peptidyl-prolyl cis-trans isomerase A (PPIA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Saguinus oedipus (Cotton-top tamarin)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP608712SWB CSB-EP608712SWB CSB-BP608712SWB CSB-MP608712SWB CSB-EP608712SWB-B |
Recombinant Saguinus oedipus Peptidyl-prolyl cis-trans isomerase A (PPIA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP608713NHM CSB-EP608713NHM CSB-BP608713NHM CSB-MP608713NHM CSB-EP608713NHM-B |
Recombinant Nomascus leucogenys Peptidyl-prolyl cis-trans isomerase A (PPIA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Pan troglodytes (Chimpanzee)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP608714EQV CSB-EP608714EQV CSB-BP608714EQV CSB-MP608714EQV CSB-EP608714EQV-B |
Recombinant Pan troglodytes Peptidyl-prolyl cis-trans isomerase A (PPIA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Pan paniscus (Pygmy chimpanzee) (Bonobo)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP611895EQU CSB-EP611895EQU CSB-BP611895EQU CSB-MP611895EQU CSB-EP611895EQU-B |
Recombinant Pan paniscus Peptidyl-prolyl cis-trans isomerase A (PPIA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Dictyostelium discoideum (Slime mold)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP684701DKK CSB-EP684701DKK CSB-BP684701DKK CSB-MP684701DKK CSB-EP684701DKK-B |
Recombinant Dictyostelium discoideum Peptidyl-prolyl cis-trans isomerase A (ppiA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP707530EZX CSB-EP707530EZX CSB-BP707530EZX CSB-MP707530EZX CSB-EP707530EZX-B |
Recombinant Pseudomonas aeruginosa Peptidyl-prolyl cis-trans isomerase A (ppiA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Pongo pygmaeus (Bornean orangutan)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP712893EXP CSB-EP712893EXP CSB-BP712893EXP CSB-MP712893EXP CSB-EP712893EXP-B |
Recombinant Pongo pygmaeus Peptidyl-prolyl cis-trans isomerase A (PPIA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Aotus trivirgatus (Night monkey) (Douroucouli)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP728571DNI CSB-EP728571DNI CSB-BP728571DNI CSB-MP728571DNI CSB-EP728571DNI-B |
Recombinant Aotus trivirgatus Peptidyl-prolyl cis-trans isomerase A (PPIA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP815495CA CSB-EP815495CA CSB-BP815495CA CSB-MP815495CA CSB-EP815495CA-B |
Recombinant Cat Peptidyl-prolyl cis-trans isomerase A (PPIA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP874675RB CSB-EP874675RB CSB-BP874675RB CSB-MP874675RB CSB-EP874675RB-B |
Recombinant Rabbit Peptidyl-prolyl cis-trans isomerase A (PPIA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Mycobacterium leprae
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP874969MVN CSB-EP874969MVN CSB-BP874969MVN CSB-MP874969MVN CSB-EP874969MVN-B |
Recombinant Probable peptidyl-prolyl cis-trans isomerase A (ppiA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPIA Proteins for Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-EP365318EGX | Recombinant Escherichia coli O6:H1 Peptidyl-prolyl cis-trans isomerase A (ppiA) | E.coli |
PPIA ELISA Kit
PPIA ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09920h | Human cyclophilin A (PPIA/CYPA) ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 0.78 ng/mL |
PPIA ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09282m | Mouse cyclophilin A,CyPA ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 3.9 pg/mL |
PPIA ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E14928r | Rat cyclophilin A,CyPA ELISA Kit | serum, plasma, cell lysates, tissue homogenates | 31.25 pg/mL |
