SCN1A
SCN1A是一種關(guān)鍵的離子通道蛋白，由大孔α亞基和多個(gè)小β亞基組成，主要表達(dá)于腦和周圍神經(jīng)中。作為電壓門控性鈉通道的一部分，SCN1A在神經(jīng)遞質(zhì)釋放的調(diào)節(jié)和機(jī)械性疼痛感知中發(fā)揮著重要作用。其結(jié)構(gòu)中的電壓感受區(qū)和孔道共同調(diào)控去極化過(guò)程，影響神經(jīng)元的興奮性。當(dāng)神經(jīng)元受到刺激時(shí)，SCN1A通道開放，引發(fā)動(dòng)作電位，參與神經(jīng)信號(hào)的傳遞。然而，SCN1A的突變可能導(dǎo)致通道功能異常，進(jìn)而引發(fā)癲癇等神經(jīng)系統(tǒng)疾病。因此，對(duì)SCN1A的結(jié)構(gòu)功能和信號(hào)通路的深入研究，有助于我們更好地理解神經(jīng)系統(tǒng)的工作原理以及相關(guān)疾病的發(fā)生機(jī)制。
熱銷產(chǎn)品
Recombinant Human Repulsive guidance molecule A (RGMA)
驗(yàn)證數(shù)據(jù)
SDS
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
SCN1A Antibodies
SCN1A for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA409848 | SCN1A Antibody | Human,Rat | ELISA,IHC |
| CSB-PA044197 | SCN1A Antibody | Human,Rat | ELISA,IHC |
| CSB-PA020834ESR1HU | SCN1A Antibody | Human | ELISA |
SCN1A Proteins
SCN1A Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP020834HU CSB-EP020834HU-B |
Recombinant Human Sodium channel protein type 1 subunit alpha (SCN1A), partial | Yeast In Vivo Biotinylation in E.coli |
| CSB-EP020834HU | Recombinant Human Sodium channel protein type 1 subunit alpha (SCN1A), partial | E.coli |
| CSB-BP020834HU | Recombinant Human Sodium channel protein type 1 subunit alpha (SCN1A), partial | Baculovirus |
