SIRPB1
SIRPB1，全稱(chēng)為信號(hào)調(diào)節(jié)蛋白β1，常見(jiàn)別名包括CD172b和SIRP-BETA-1。該蛋白屬于免疫球蛋白超家族，參與多種細(xì)胞信號(hào)傳導(dǎo)過(guò)程。SIRPB1通過(guò)與CD47蛋白相互作用，調(diào)節(jié)細(xì)胞增殖、凋亡和免疫應(yīng)答等生物學(xué)功能。研究表明，SIRPB1在腦部衰老過(guò)程中發(fā)揮重要作用，其表達(dá)水平與大腦年齡差距相關(guān)。此外，SIRPB1還與某些神經(jīng)退行性疾病有關(guān)，如阿爾茨海默病和帕金森病。在藥物研發(fā)方面，針對(duì)SIRPB1的抗體藥物已進(jìn)入臨床試驗(yàn)階段，用于治療自身免疫病和炎性疾病。此外，SIRPB1也被視為抗衰老藥物研發(fā)的潛在靶點(diǎn)，相關(guān)研究正在深入進(jìn)行中。
熱銷(xiāo)產(chǎn)品
Recombinant Human Signal-regulatory protein beta-1 (SIRPB1), partial (CSB-MP021335HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
SIRPB1 Antibody (CSB-PA021335LA01HU)
驗(yàn)證數(shù)據(jù)
Immunofluorescence staining of U251 cell with CSB-PA021335LA01HU at 1:10, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunofluorescence staining of U251 cell with 5% goat serum, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Western Blot
Positive WB detected in: THP-1 whole cell lysate(20μg), U87 whole cell lysate(20μg), A549 whole cell lysate(20μg), PC-3 whole cell lysate(20μg)
All lanes: SIRPB1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/40000 dilution
Predicted band size: 43,19 kDa
Observed band size: 43,86 kDa
Exposure time: 120s
Immunofluorescence staining of Hela cell with CSB-PA021335LA01HU at 1:10, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunofluorescence staining of Hela cell with 5% goat serum, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
SIRPB1 Antibodies
SIRPB1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA021335GA01HU | SIRPB1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA988979 | SIRPB1 Antibody | Human | ELISA,WB |
| CSB-PA001428 | SIRPB1 Antibody | Human | WB, ELISA |
| CSB-PA021335LA01HU | SIRPB1 Antibody | Human | ELISA, WB, IF |
| CSB-PA021335LB01HU | SIRPB1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA021335LC01HU | SIRPB1 Antibody, FITC conjugated | Human | |
| CSB-PA021335LD01HU | SIRPB1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA732939LA01HU | SIRPB1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA732939LB01HU | SIRPB1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA732939LC01HU | SIRPB1 Antibody, FITC conjugated | Human | |
| CSB-PA732939LD01HU | SIRPB1 Antibody, Biotin conjugated | Human | ELISA |
SIRPB1 Proteins
SIRPB1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP021335HU | Recombinant Human Signal-regulatory protein beta-1 (SIRPB1), partial | Yeast |
| CSB-YP732939HU CSB-EP732939HU CSB-BP732939HU CSB-MP732939HU CSB-EP732939HU-B |
Recombinant Human Signal-regulatory protein beta-1 isoform 3 (SIRPB1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-MP021335HU | Recombinant Human Signal-regulatory protein beta-1 (SIRPB1), partial | Mammalian cell |
| CSB-EP021335HU | Recombinant Human Signal-regulatory protein beta-1 (SIRPB1), partial | E.coli |
| CSB-BP021335HU CSB-EP021335HU-B |
Recombinant Human Signal-regulatory protein beta-1 (SIRPB1), partial | Baculovirus In Vivo Biotinylation in E.coli |
