TACSTD2
TACSTD2，即腫瘤相關(guān)鈣信號轉(zhuǎn)導(dǎo)子2，別名TROP2、EGP-1、GA733-1、M1S1等，由人類TACSTD2基因編碼，該基因位于1號染色體的1p32.1區(qū)域。TACSTD2蛋白是一種細胞表面糖蛋白，屬于單次跨膜蛋白，由323個氨基酸組成，具有一個疏水性前導(dǎo)肽、一個細胞外結(jié)構(gòu)域、一個跨膜結(jié)構(gòu)域和一個胞質(zhì)尾部。
TACSTD2的作用機制涉及其胞質(zhì)尾部的高度保守的磷脂酰肌醇4,5-二磷酸(PIP2)結(jié)合序列，該序列在信號轉(zhuǎn)導(dǎo)中起重要作用。TACSTD2通過與PIP2的相互作用以及酪氨酸和絲氨酸磷酸化位點參與細胞信號傳導(dǎo)，影響細胞周期進程。
TACSTD2在多種惡性腫瘤中過表達，與腫瘤的發(fā)生、侵襲和轉(zhuǎn)移有關(guān)，是一種重要的癌基因。TACSTD2的表達程度與疾病的惡性程度相關(guān)，其過表達可促進腫瘤細胞生長、增殖和轉(zhuǎn)移，故此成為了開發(fā)抗體偶聯(lián)藥物的新靶點。
熱銷產(chǎn)品
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured in cell activity assay using U937 cells, the EC50 for this effect is 190.2-298.6 ng/ml.
The purity of TACSTD2 was greater than 95% as determined by SEC-HPLC
TROP2 monoclonal antibody (CSB-RA023072MA1HU)
驗證數(shù)據(jù)
The Binding Activity of Huamn TROP2 with Anti-TROP2 recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TROP2 (CSB-MP023072HU1d7) at 2 μg/mL can bind Anti-TROP2 recombinant antibody, the EC50 is 0.7284-1.075 ng/mL.
The Binding Activity of Huamn TROP2 with Anti-TROP2 recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TROP2(CSB-MP023072HU2) at 2 μg/mL can bind Anti-TROP2 recombinant antibody, the EC50 is 0.9108-1.640 ng/mL.
The Binding Activity of Macaca fascicularit TROP2 with Anti-TROP2 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA.Immobilized Macaca fascicularis TACSTD2(CSB-MP6581MOV) at 2 μg/mL can bind Anti-TACSTD2 recombinant antibody The EC50 is 1.720-2.009 ng/mL.
TACSTD2 Antibodies
TACSTD2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA170174 | TACSTD2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA023072ESR1HU | TACSTD2 Antibody | Human | ELISA, IHC |
| CSB-PA004333 | TACSTD2 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA830561 | TACSTD2 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-RA023072MA1HU | TROP2 monoclonal antibody | Human, Macaca fascicularis | ELISA |
TACSTD2 Proteins
TACSTD2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023072RA CSB-EP023072RA CSB-BP023072RA CSB-MP023072RA CSB-EP023072RA-B |
Recombinant Rat Tumor-associated calcium signal transducer 2 (Tacstd2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TACSTD2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-EP023072MO CSB-BP023072MO CSB-EP023072MO-B |
Recombinant Mouse Tumor-associated calcium signal transducer 2 (Tacstd2), partial | E.coli Baculovirus In Vivo Biotinylation in E.coli |
TACSTD2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-CF023072HU | Recombinant Human Tumor-associated calcium signal transducer 2 (TACSTD2) | in vitro E.coli expression system |
| CSB-MP023072HU1 | Recombinant Human Tumor-associated calcium signal transducer 2 (TACSTD2), partial (Active) | Mammalian cell |
| CSB-MP023072HU2 | Recombinant Human Tumor-associated calcium signal transducer 2 (TACSTD2), partial (Active) | Mammalian cell |
| CSB-MP023072HU1d7 | Recombinant Human Tumor-associated calcium signal transducer 2 (TACSTD2), partial (Active) | Mammalian cell |
