TNFSF10
TNFSF10（腫瘤壞死因子超家族成員10）又稱(chēng)TRAIL（腫瘤壞死因子相關(guān)凋亡誘導(dǎo)配體），是一種Ⅱ型跨膜蛋白，其可溶性形式通過(guò)激活死亡受體DR4和DR5觸發(fā)細(xì)胞凋亡。TNFSF10在免疫監(jiān)視中起關(guān)鍵作用，可選擇性誘導(dǎo)癌細(xì)胞凋亡而不損傷正常組織，這一特性使其成為腫瘤治療的熱點(diǎn)靶點(diǎn)。其作用涉及線(xiàn)粒體途徑和Caspase蛋白酶級(jí)聯(lián)反應(yīng)，同時(shí)受凋亡抑制蛋白c-FLIP和Bcl-2家族調(diào)控。
TRAIL在肝癌、肺癌等多種惡性腫瘤中表達(dá)異常，其信號(hào)通路失調(diào)與腫瘤耐藥密切相關(guān)。近年來(lái)，針對(duì)TRAIL受體的單克隆抗體如Conatumumab、Lexatumumab已進(jìn)入臨床試驗(yàn)，但單藥療效有限，現(xiàn)多探索與化療或靶向藥的聯(lián)合應(yīng)用。另有研究揭示TRAIL在阿爾茨海默病中可能通過(guò)清除異常蛋白沉積發(fā)揮保護(hù)作用，但過(guò)度激活也可能導(dǎo)致神經(jīng)元損傷。目前新型融合蛋白如TRAIL-Fc和三特異性抗體正在開(kāi)發(fā)中，旨在提高受體結(jié)合特異性和克服耐藥性瓶頸。
熱銷(xiāo)產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
TNFSF10 Antibody (CSB-PA07475A0Rb)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA07475A0Rb at dilution of 1:100
Immunofluorescence staining of A549 cells with CSB-PA07475A0Rb at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
TNFSF10 Antibodies
TNFSF10 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA07475A0Rb | TNFSF10 Antibody | Human | ELISA, IHC, IF |
| CSB-PA023985GA01HU | TNFSF10 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA272904 | TNFSF10 Antibody | Human | ELISA,WB,IF |
| CSB-PA004326 | TNFSF10 Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA005996 | TNFSF10 Antibody | Human | WB, ELISA |
TNFSF10 Proteins
TNFSF10 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP023985MO CSB-EP023985MO CSB-BP023985MO CSB-MP023985MO CSB-EP023985MO-B |
Recombinant Mouse Tumor necrosis factor ligand superfamily member 10 (Tnfsf10) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TNFSF10 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP023985HU CSB-BP023985HU CSB-MP023985HU CSB-EP023985HU-B |
Recombinant Human Tumor necrosis factor ligand superfamily member 10 (TNFSF10), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP023985HUe0 | Recombinant Human Tumor necrosis factor ligand superfamily member 10 (TNFSF10), partial | E.coli |
| CSB-EP023985HU | Recombinant Human Tumor necrosis factor ligand superfamily member 10 (TNFSF10), partial | E.coli |
| CSB-CF023985HU | Recombinant Human Tumor necrosis factor ligand superfamily member 10 (TNFSF10) | in vitro E.coli expression system |
| CSB-AP004901HU | Recombinant Human Tumor necrosis factor ligand superfamily member 10 (TNFSF10), partial (Active) | E.coli |
TNFSF10 ELISA Kit
TNFSF10 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-E04750h | Human soluble tumor necrosis factor-related apoptosis inducing ligand,sTRAIL ELISA KIT | serum, plasma, tissue homogenates | 3.9 pg/ml |
| CSB-E04750h-IS | Human soluble tumor necrosis factor-related apoptosis inducing ligand,sTRAIL ELISA KIT | serum, plasma, cell culture supernates, tissue homogenates | 1.95 pg/mL |
TNFSF10 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-E07371m | Mouse soluble tumor necrosis factor-related apoptosis inducing ligand,sTRAIL ELISA KIT | serum, plasma, tissue homogenates | 7.8 pg/ml |
TNFSF10 ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-E13904r | Rat tumor necrosis factor-related apoptosis inducing ligand,TRAIL ELISA Kit | serum, plasma, tissue homogenates | 3.9 pg/mL |
