PPP3R1 Antibody, FITC conjugated
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中文名稱：PPP3R1兔多克隆抗體, FITC偶聯
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貨號：CSB-PA018575LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PPP3R1 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：alpha isoform (calcineurin B; type I) antibody; calcineurin B; type I (19kDa) antibody; Calcineurin subunit B type 1 antibody; CALNB1 antibody; CANB1_HUMAN antibody; Cna2 antibody; CNB antibody; CNB1 antibody; OTTHUMP00000201960 antibody; OTTHUMP00000201961 antibody; Ppp3r1 antibody; PPP3R1 protein phosphatase 3 (formerly 2B); regulatory subunit B; alpha isoform antibody; protein phosphatase3 (formerly2B); regulatory subunit B; alpha isoform antibody; Protein phosphatase 2B regulatory subunit 1 antibody; Protein phosphatase 2B regulatory subunit B alpha antibody; protein phosphatase 3 (formerly 2B); regulatory subunit B; 19kDa; alpha isoform (calcineurin B; type I) antibody; Protein phosphatase 3 (formerly 2B); regulatory subunit B (19kD); alpha isoform (calcineurin B; type I) antibody; Protein phosphatase 3 regulatory subunit B alpha antibody; Protein phosphatase 3 regulatory subunit B alpha isoform 1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Calcineurin subunit B type 1 protein (11-170AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
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基因功能參考文獻：
- expression of PPP3R1 decreased respectively in psoriatic lesions and HaCaT cells. PMID: 29181737
- The CnB 5I/5D variation was found to be significantly associated with CAD. The 5-base pair deletion results in increased serum calcineurin levels. PMID: 28827117
- we report that exogenous CnB is taken up by cells in a time- and concentration-dependent manner via clathrin-dependent receptor-mediated internalization. Our findings further confirm that uptake is mediated by the TLR4/MD2 complex together with the co-receptor CD14 PMID: 27090571
- CnB is a novel host-derived immunostimulatory factor, having a role as an agonist in monocytes, and specificity in TLR4 signaling through TRAF3 and TRAF6, in response to various agonists. PMID: 26471241
- Data (including data from micro-dissected trophoblasts and trophoblastic BeWo cell line) suggest that microRNA-512-3p participates in placental function by targeting PPP3R1, encoding a regulatory subunit of calcineurin B. PMID: 24246042
- Further evidence that specific variations in MAPT (rs3785883) and PPP3R1 (rs1868402) are associated with accelerated progression of Alzheimer's disease PMID: 23727081
- Expression level of PPP3R1 and GATA4, and NFATC4 genes for transcription factors did not differ in studied subgroups of patients. PMID: 23888774
- Pancreatic beta cells lacking Cnb1 fail to express genes revealed to be direct NFAT targets required for replication, insulin storage, and secretion. PMID: 22814600
- These findings reveal a novel signaling pathway (CnB-CD11b-NF-kappaB-TRAIL) regulating TRAIL expression and may help to understand the roles of the calcineurin B subunit in the regulation of innate immunity. PMID: 22197822
- immunostimulatory protein and acts as a vaccine adjuvant inducing protective cellular and humoral responses against pneumococcal infection PMID: 21722668
- CnB M118K fails to enhance the activities of NF-AT and p53 induced by CnA in HeLa-s cells. PMID: 21910968
- CNB binds to proteasome subunit alpha type 7 (PSMA7) and inhibits the transactivation activity of hypoxia-inducible factor-1alpha (HIF-1alpha) via the proteasome pathway. PMID: 21256111
- these data imply novel functions of calcineurin and NF-kappaB for successful IS maturation. PMID: 17038582
- Endothelin 1 (ET-1) activates calcineurin and causes nuclear translocation of NFATc1, implicating the pathway in the ET-1-mediated stimulation of osteoblasts. PMID: 17237284
- IGF-1/PPP3R1 gene polymorphisms influence muscle phenotypic responses to strength training in both black and white older men and women. PMID: 17761791
- No significant differences in calcineurin b expression was observed between patients with schizophrenia and normal controls PMID: 18343007
- Overexpression of calcineurin B subunit enhances the oncogenic potential of HEK293 cells PMID: 18422742
- Study found that although calcineurin/NFAT signalling pathway has an important, non-redundant role in the regulation of lymphocyte developmental checkpoints, it is not essential for the development of blood myeloid lineages. PMID: 18818667
- CNB gene 5I/5D polymorphism is associated with the risk of left ventricular hypertrophy and physical performance of athletes. PMID: 18825932
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亞細胞定位：Cytoplasm, cytosol. Cell membrane. Cell membrane, sarcolemma. Cell membrane; Lipid-anchor.
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蛋白家族：Calcineurin regulatory subunit family
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