PPP3R1 Antibody

Name: PPP3R1 Antibody
Brand: CUSABIO
SKU: CSB-PA018575LA01HU

說明書

中文名稱：

PPP3R1兔多克隆抗體
貨號：

CSB-PA018575LA01HU
規格：

￥440
圖片：
Western blot
All lanes: PPP3R1 antibody at 1µg/ml
Lane 1: K562 whole cell lysate
Lane 2: Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 20 kDa
Observed band size: 20 kDa
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PPP3R1 Polyclonal antibody
Uniprot No.：

P63098
基因名：

PPP3R1
別名：

alpha isoform (calcineurin B; type I) antibody; calcineurin B; type I (19kDa) antibody; Calcineurin subunit B type 1 antibody; CALNB1 antibody; CANB1_HUMAN antibody; Cna2 antibody; CNB antibody; CNB1 antibody; OTTHUMP00000201960 antibody; OTTHUMP00000201961 antibody; Ppp3r1 antibody; PPP3R1 protein phosphatase 3 (formerly 2B); regulatory subunit B; alpha isoform antibody; protein phosphatase3 (formerly2B); regulatory subunit B; alpha isoform antibody; Protein phosphatase 2B regulatory subunit 1 antibody; Protein phosphatase 2B regulatory subunit B alpha antibody; protein phosphatase 3 (formerly 2B); regulatory subunit B; 19kDa; alpha isoform (calcineurin B; type I) antibody; Protein phosphatase 3 (formerly 2B); regulatory subunit B (19kD); alpha isoform (calcineurin B; type I) antibody; Protein phosphatase 3 regulatory subunit B alpha antibody; Protein phosphatase 3 regulatory subunit B alpha isoform 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Calcineurin subunit B type 1 protein (11-170AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PPP3R1 Antibody (CSB-PA018575LA01HU)，的標記方式是Non-conjugated。對于PPP3R1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA018575LB01HU	PPP3R1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA018575LC01HU	PPP3R1 Antibody, FITC conjugated
Biotin	CSB-PA018575LD01HU	PPP3R1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
基因功能參考文獻：
1. expression of PPP3R1 decreased respectively in psoriatic lesions and HaCaT cells. PMID: 29181737
2. The CnB 5I/5D variation was found to be significantly associated with CAD. The 5-base pair deletion results in increased serum calcineurin levels. PMID: 28827117
3. we report that exogenous CnB is taken up by cells in a time- and concentration-dependent manner via clathrin-dependent receptor-mediated internalization. Our findings further confirm that uptake is mediated by the TLR4/MD2 complex together with the co-receptor CD14 PMID: 27090571
4. CnB is a novel host-derived immunostimulatory factor, having a role as an agonist in monocytes, and specificity in TLR4 signaling through TRAF3 and TRAF6, in response to various agonists. PMID: 26471241
5. Data (including data from micro-dissected trophoblasts and trophoblastic BeWo cell line) suggest that microRNA-512-3p participates in placental function by targeting PPP3R1, encoding a regulatory subunit of calcineurin B. PMID: 24246042
6. Further evidence that specific variations in MAPT (rs3785883) and PPP3R1 (rs1868402) are associated with accelerated progression of Alzheimer's disease PMID: 23727081
7. Expression level of PPP3R1 and GATA4, and NFATC4 genes for transcription factors did not differ in studied subgroups of patients. PMID: 23888774
8. Pancreatic beta cells lacking Cnb1 fail to express genes revealed to be direct NFAT targets required for replication, insulin storage, and secretion. PMID: 22814600
9. These findings reveal a novel signaling pathway (CnB-CD11b-NF-kappaB-TRAIL) regulating TRAIL expression and may help to understand the roles of the calcineurin B subunit in the regulation of innate immunity. PMID: 22197822
10. immunostimulatory protein and acts as a vaccine adjuvant inducing protective cellular and humoral responses against pneumococcal infection PMID: 21722668
11. CnB M118K fails to enhance the activities of NF-AT and p53 induced by CnA in HeLa-s cells. PMID: 21910968
12. CNB binds to proteasome subunit alpha type 7 (PSMA7) and inhibits the transactivation activity of hypoxia-inducible factor-1alpha (HIF-1alpha) via the proteasome pathway. PMID: 21256111
13. these data imply novel functions of calcineurin and NF-kappaB for successful IS maturation. PMID: 17038582
14. Endothelin 1 (ET-1) activates calcineurin and causes nuclear translocation of NFATc1, implicating the pathway in the ET-1-mediated stimulation of osteoblasts. PMID: 17237284
15. IGF-1/PPP3R1 gene polymorphisms influence muscle phenotypic responses to strength training in both black and white older men and women. PMID: 17761791
16. No significant differences in calcineurin b expression was observed between patients with schizophrenia and normal controls PMID: 18343007
17. Overexpression of calcineurin B subunit enhances the oncogenic potential of HEK293 cells PMID: 18422742
18. Study found that although calcineurin/NFAT signalling pathway has an important, non-redundant role in the regulation of lymphocyte developmental checkpoints, it is not essential for the development of blood myeloid lineages. PMID: 18818667
19. CNB gene 5I/5D polymorphism is associated with the risk of left ventricular hypertrophy and physical performance of athletes. PMID: 18825932
顯示更多

收起更多
亞細胞定位：

Cytoplasm, cytosol. Cell membrane. Cell membrane, sarcolemma. Cell membrane; Lipid-anchor.
蛋白家族：

Calcineurin regulatory subunit family
數據庫鏈接：

HGNC: 9317

OMIM: 601302

KEGG: hsa:5534

STRING: 9606.ENSP00000234310

UniGene: Hs.280604

Most popular with customers

YWHAG Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
YWHAB Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF, FC

Species Reactivity: Human, Mouse, Rat
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
XPNPEP1 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human