TNFRSF10C Antibody, Biotin conjugated
-
中文名稱：TNFRSF10C兔多克隆抗體, Biotin偶聯(lián)
-
貨號：CSB-PA08189D0Rb
-
規(guī)格：￥880
-
其他：
產(chǎn)品詳情
-
產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) TNFRSF10C Polyclonal antibody
-
Uniprot No.：
-
基因名：
-
別名：TNFRSF10C antibody; DCR1 antibody; LIT antibody; TRAILR3 antibody; TRID antibody; UNQ321/PRO366 antibody; Tumor necrosis factor receptor superfamily member 10C antibody; Antagonist decoy receptor for TRAIL/Apo-2L antibody; Decoy TRAIL receptor without death domain antibody; Decoy receptor 1 antibody; DcR1 antibody; Lymphocyte inhibitor of TRAIL antibody; TNF-related apoptosis-inducing ligand receptor 3 antibody; TRAIL receptor 3 antibody; TRAIL-R3 antibody; TRAIL receptor without an intracellular domain antibody; CD antigen CD263 antibody
-
宿主：Rabbit
-
反應(yīng)種屬：Human
-
免疫原：Recombinant Human Tumor necrosis factor receptor superfamily member 10C protein (26-236AA)
-
免疫原種屬：Homo sapiens (Human)
-
標(biāo)記方式：Biotin
-
克隆類型：Polyclonal
-
抗體亞型：IgG
-
純化方式：>95%, Protein G purified
-
濃度：It differs from different batches. Please contact us to confirm it.
-
保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
-
應(yīng)用范圍：ELISA
-
Protocols：
-
儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情
-
功能：Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
-
基因功能參考文獻(xiàn)：
- High levels of TRAIL-R3 and CCR-2 expression in tumor epithelial cells identified patients with early breast cancer with poor outcomes. PMID: 28420351
- DcR1 levels in serum sample which were significantly lower in AMD patients. PMID: 24534820
- DcR1 upregulation mediates temozolomide resistance. PMID: 25808868
- GATA4 and DcR1 promoter hypermethylation is tumor specific event in glioblastoma but they promoter methylation cannot be considered as a prognostic marker of glioblastoma survival. PMID: 23320456
- Primary EOC is associated to a lower TRAIL-R3 expression. PMID: 22555108
- Data show that about 20% of AML patients highly expressed decoy receptor TRAIL-R3, which was strongly correlated to a shortened overall survival. PMID: 21281967
- Decoy receptors DcR1 and DcR2 on CD8+ T cells, but not on CD4-positive T cells, are positively correlated with patients' DAS scores. PMID: 20799941
- Results suggest that DcR1 expression occurs in a subset of endometrial carcinomas and may contribute to resistance to TRAIL-induced apoptosis. PMID: 19936781
- analysis of the transcription initiation sites and promoter structure of the TRAIL-R3 gene PMID: 12417331
- cloned and characterized a p53 consensus element located within the first intron of the TRAIL-R3 gene PMID: 14623878
- Our results demonstrate that DcR1 and DcR2 genes are frequently methylated in various tumor types, and aberrant methylation was the cause for silencing of DcR1 and DcR2 expression. PMID: 14999791
- The DcR1 had no death domain and was anchored to the membrane via a glycophosphatidyl inositol tail. PMID: 15538968
- Resistance to TRAIL-induced apoptosis in acute myeloid leukemia cells is associated with expression of TRAIL-R3. PMID: 15921376
- tryptophol induces apoptosis through DR5 and the resistance of PBL to tryptophol-induced apoptosis might be due to competition from DcR1 PMID: 17690453
- p53 negatively regulates oxaliplatin-mediated TRAIL-induced apoptotic activity through DcR1 upregulation. PMID: 18345033
- TRAILR3 (TNF-related apoptosis inducing ligand receptor 3) levels were significantly higher in lung parenchyma in subjects with emphysema PMID: 18511705
- Liver metastases with low DcR1/TNFRSF10C mRNA expression were more likely to present with extrahepatic metastases PMID: 18590575
- inactivation of TNFRSF10C by chromosomal deletion and promoter methylation may play an important role in prostate cancer development PMID: 19035483
- Low DCR1 is associated with non-small cell lung cancer. PMID: 19661294
顯示更多
收起更多
-
亞細(xì)胞定位：Cell membrane; Lipid-anchor, GPI-anchor.
-
組織特異性：Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.
-
數(shù)據(jù)庫鏈接：
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-
