TNFRSF10C Antibody

中文名稱：

TNFRSF10C兔多克隆抗體
貨號：

CSB-PA08189A0Rb
規(guī)格：

￥440
圖片：
Immunofluorescent analysis of A549 cells using CSB-PA08189A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Immunofluorescent analysis of HepG2 cells using CSB-PA08189A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) TNFRSF10C Polyclonal antibody
Uniprot No.：

O14798
基因名：

TNFRSF10C
別名：

TNFRSF10C antibody; DCR1 antibody; LIT antibody; TRAILR3 antibody; TRID antibody; UNQ321/PRO366 antibody; Tumor necrosis factor receptor superfamily member 10C antibody; Antagonist decoy receptor for TRAIL/Apo-2L antibody; Decoy TRAIL receptor without death domain antibody; Decoy receptor 1 antibody; DcR1 antibody; Lymphocyte inhibitor of TRAIL antibody; TNF-related apoptosis-inducing ligand receptor 3 antibody; TRAIL receptor 3 antibody; TRAIL-R3 antibody; TRAIL receptor without an intracellular domain antibody; CD antigen CD263 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Tumor necrosis factor receptor superfamily member 10C protein (26-236AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，TNFRSF10C Antibody (CSB-PA08189A0Rb)，的標(biāo)記方式是Non-conjugated。對于TNFRSF10C Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA08189B0Rb	TNFRSF10C Antibody, HRP conjugated	ELISA
FITC	CSB-PA08189C0Rb	TNFRSF10C Antibody, FITC conjugated
Biotin	CSB-PA08189D0Rb	TNFRSF10C Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
基因功能參考文獻：
1. High levels of TRAIL-R3 and CCR-2 expression in tumor epithelial cells identified patients with early breast cancer with poor outcomes. PMID: 28420351
2. DcR1 levels in serum sample which were significantly lower in AMD patients. PMID: 24534820
3. DcR1 upregulation mediates temozolomide resistance. PMID: 25808868
4. GATA4 and DcR1 promoter hypermethylation is tumor specific event in glioblastoma but they promoter methylation cannot be considered as a prognostic marker of glioblastoma survival. PMID: 23320456
5. Primary EOC is associated to a lower TRAIL-R3 expression. PMID: 22555108
6. Data show that about 20% of AML patients highly expressed decoy receptor TRAIL-R3, which was strongly correlated to a shortened overall survival. PMID: 21281967
7. Decoy receptors DcR1 and DcR2 on CD8+ T cells, but not on CD4-positive T cells, are positively correlated with patients' DAS scores. PMID: 20799941
8. Results suggest that DcR1 expression occurs in a subset of endometrial carcinomas and may contribute to resistance to TRAIL-induced apoptosis. PMID: 19936781
9. analysis of the transcription initiation sites and promoter structure of the TRAIL-R3 gene PMID: 12417331
10. cloned and characterized a p53 consensus element located within the first intron of the TRAIL-R3 gene PMID: 14623878
11. Our results demonstrate that DcR1 and DcR2 genes are frequently methylated in various tumor types, and aberrant methylation was the cause for silencing of DcR1 and DcR2 expression. PMID: 14999791
12. The DcR1 had no death domain and was anchored to the membrane via a glycophosphatidyl inositol tail. PMID: 15538968
13. Resistance to TRAIL-induced apoptosis in acute myeloid leukemia cells is associated with expression of TRAIL-R3. PMID: 15921376
14. tryptophol induces apoptosis through DR5 and the resistance of PBL to tryptophol-induced apoptosis might be due to competition from DcR1 PMID: 17690453
15. p53 negatively regulates oxaliplatin-mediated TRAIL-induced apoptotic activity through DcR1 upregulation. PMID: 18345033
16. TRAILR3 (TNF-related apoptosis inducing ligand receptor 3) levels were significantly higher in lung parenchyma in subjects with emphysema PMID: 18511705
17. Liver metastases with low DcR1/TNFRSF10C mRNA expression were more likely to present with extrahepatic metastases PMID: 18590575
18. inactivation of TNFRSF10C by chromosomal deletion and promoter methylation may play an important role in prostate cancer development PMID: 19035483
19. Low DCR1 is associated with non-small cell lung cancer. PMID: 19661294
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亞細胞定位：

Cell membrane; Lipid-anchor, GPI-anchor.
組織特異性：

Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.
數(shù)據(jù)庫鏈接：

HGNC: 11906

OMIM: 603613

KEGG: hsa:8794

STRING: 9606.ENSP00000349324

UniGene: Hs.655801

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